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PSTB - Phosphate import ATP-binding protein PstB
UniProt: P0AAH0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10783
Length: 257 (241)
Sequences: 70373
Seq/Len: 292.00

PSTB
Paralog alert: 0.94 [within 20: 0.84] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
40_A 219_S 3.331 1.00
12_Q 32_D 3.304 1.00
37_Q 221_H 3.205 1.00
71_E 78_N 3.069 1.00
14_R 71_E 3.063 1.00
15_N 28_N 3.056 1.00
146_K 149_Q 2.898 1.00
92_K 173_E 2.81 1.00
24_H 27_K 2.749 1.00
34_A 37_Q 2.669 1.00
12_Q 73_L 2.653 1.00
39_T 223_A 2.637 1.00
221_H 233_F 2.626 1.00
27_K 229_E 2.622 1.00
17_N 28_N 2.441 1.00
13_V 16_L 2.329 1.00
234_S 238_D 2.243 1.00
129_R 171_R 2.22 1.00
19_Y 24_H 2.186 1.00
17_N 24_H 2.151 1.00
18_F 55_T 2.136 1.00
75_D 173_E 2.113 1.00
17_N 69_E 2.106 1.00
14_R 73_L 2.103 1.00
235_N 238_D 2.084 1.00
135_T 140_W 2.073 1.00
107_I 154_L 1.932 1.00
223_A 230_L 1.891 1.00
171_R 203_Y 1.854 1.00
223_A 233_F 1.841 1.00
37_Q 220_D 1.839 1.00
108_Y 148_H 1.821 1.00
35_K 173_E 1.808 1.00
15_N 30_N 1.806 1.00
108_Y 131_Q 1.777 1.00
20_Y 25_A 1.743 1.00
108_Y 127_D 1.713 1.00
108_Y 130_V 1.704 1.00
131_Q 147_L 1.697 1.00
132_W 136_K 1.694 1.00
127_D 131_Q 1.674 1.00
108_Y 112_A 1.647 1.00
136_K 198_E 1.631 1.00
134_L 147_L 1.623 1.00
122_S 125_D 1.537 1.00
53_L 208_V 1.526 1.00
129_R 132_W 1.509 1.00
108_Y 147_L 1.498 1.00
18_F 68_A 1.497 1.00
53_L 176_L 1.483 1.00
33_I 39_T 1.48 1.00
31_L 223_A 1.477 1.00
98_Q 156_G 1.461 1.00
26_L 55_T 1.438 1.00
18_F 60_F 1.422 1.00
73_L 78_N 1.403 0.99
149_Q 153_S 1.4 0.99
112_A 130_V 1.398 0.99
13_V 56_F 1.396 0.99
19_Y 68_A 1.392 0.99
14_R 32_D 1.381 0.99
131_Q 135_T 1.378 0.99
128_E 132_W 1.36 0.99
111_I 169_A 1.341 0.99
135_T 144_K 1.339 0.99
234_S 239_L 1.335 0.99
17_N 27_K 1.329 0.99
209_T 215_A 1.307 0.99
112_A 126_M 1.302 0.99
10_K 75_D 1.302 0.99
13_V 31_L 1.288 0.99
106_S 109_D 1.28 0.99
75_D 92_K 1.257 0.99
18_F 51_T 1.252 0.99
110_N 166_R 1.24 0.98
94_G 172_P 1.216 0.98
39_T 233_F 1.209 0.98
52_L 225_M 1.208 0.98
129_R 133_A 1.203 0.98
200_K 220_D 1.202 0.98
56_F 206_V 1.202 0.98
177_L 196_I 1.184 0.98
34_A 221_H 1.183 0.98
112_A 127_D 1.181 0.98
61_E 67_R 1.169 0.97
14_R 30_N 1.167 0.97
111_I 134_L 1.161 0.97
134_L 139_L 1.151 0.97
20_Y 51_T 1.148 0.97
133_A 169_A 1.147 0.97
13_V 52_L 1.146 0.97
57_N 95_M 1.13 0.97
19_Y 25_A 1.124 0.97
132_W 135_T 1.118 0.96
55_T 72_I 1.118 0.96
39_T 221_H 1.113 0.96
78_N 81_T 1.108 0.96
107_I 162_L 1.101 0.96
189_T 214_Q 1.087 0.96
96_V 164_I 1.087 0.96
195_L 198_E 1.084 0.96
38_V 205_V 1.083 0.96
226_Y 231_I 1.081 0.95
137_A 165_A 1.078 0.95
35_K 75_D 1.077 0.95
29_I 52_L 1.073 0.95
245_K 248_T 1.07 0.95
132_W 171_R 1.069 0.95
85_D 88_L 1.068 0.95
138_A 191_R 1.058 0.95
197_T 200_K 1.05 0.94
38_V 200_K 1.049 0.94
231_I 245_K 1.048 0.94
154_L 162_L 1.046 0.94
38_V 207_I 1.046 0.94
125_D 128_E 1.041 0.94
109_D 112_A 1.04 0.94
193_E 214_Q 1.037 0.94
105_M 109_D 1.017 0.93
15_N 69_E 1.015 0.93
131_Q 144_K 1.014 0.93
58_K 61_E 1.013 0.93
173_E 203_Y 1.004 0.93
200_K 205_V 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.96111000.014Contact Map0.864
2it1A20.91831000.017Contact Map0.864
2yyzA10.91831000.017Contact Map0.797
1g29120.93391000.02Contact Map0.88
1v43A10.94551000.021Contact Map0.831
1oxxK10.93391000.024Contact Map0.782
3rlfA20.91831000.025Contact Map0.842
3fvqA20.93771000.026Contact Map0.784
1z47A20.93771000.033Contact Map0.835
2oljA20.94551000.04Contact Map0.87

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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