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SAPF - Peptide transport system ATP-binding protein SapF
UniProt: P0AAH8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12305
Length: 268 (247)
Sequences: 69040
Seq/Len: 279.51

SAPF
Paralog alert: 0.95 [within 20: 0.88] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
44_A 218_S 3.273 1.00
41_Q 220_Q 3.145 1.00
7_E 36_T 3.102 1.00
143_H 146_Y 3.04 1.00
10_N 32_P 2.941 1.00
9_R 70_E 2.903 1.00
70_E 77_P 2.885 1.00
89_R 170_K 2.878 1.00
43_L 222_L 2.756 1.00
28_E 31_K 2.719 1.00
7_E 72_L 2.63 1.00
38_R 41_Q 2.487 1.00
31_K 228_E 2.479 1.00
220_Q 232_R 2.463 1.00
135_R 140_L 2.457 1.00
12_S 32_P 2.263 1.00
129_Q 168_R 2.236 1.00
74_D 170_K 2.215 1.00
13_K 59_M 2.213 1.00
8_V 11_L 2.2 1.00
14_T 28_E 2.199 1.00
233_G 237_D 2.182 1.00
234_S 237_D 2.124 1.00
12_S 68_S 2.053 1.00
222_L 229_V 2.044 1.00
12_S 28_E 2.03 1.00
107_I 151_L 2.029 1.00
131_I 144_V 2.027 1.00
134_M 144_V 2.026 1.00
108_S 145_S 1.916 1.00
9_R 72_L 1.906 1.00
195_E 199_K 1.882 1.00
39_E 170_K 1.844 1.00
108_S 144_V 1.842 1.00
41_Q 219_D 1.764 1.00
136_M 195_E 1.749 1.00
222_L 232_R 1.742 1.00
10_N 34_S 1.736 1.00
15_F 29_A 1.734 1.00
108_S 131_I 1.719 1.00
168_R 202_I 1.694 1.00
136_M 200_Q 1.661 1.00
13_K 67_T 1.624 1.00
129_Q 132_E 1.62 1.00
122_E 125_Q 1.618 1.00
132_E 136_M 1.608 1.00
136_M 199_K 1.604 1.00
108_S 130_I 1.599 1.00
127_R 131_I 1.564 1.00
146_Y 150_M 1.536 1.00
95_Q 153_P 1.525 1.00
74_D 89_R 1.483 1.00
72_L 77_P 1.47 1.00
57_A 207_V 1.467 1.00
233_G 238_V 1.45 1.00
108_S 127_R 1.443 1.00
14_T 67_T 1.434 1.00
197_Q 219_D 1.428 1.00
112_D 130_I 1.422 1.00
112_D 126_R 1.416 1.00
9_R 36_T 1.395 0.99
208_T 214_M 1.391 0.99
35_F 222_L 1.39 0.99
13_K 64_I 1.384 0.99
108_S 112_D 1.375 0.99
15_F 55_T 1.356 0.99
30_V 59_M 1.35 0.99
128_K 132_E 1.341 0.99
8_V 60_L 1.334 0.99
37_L 43_L 1.309 0.99
12_S 31_K 1.306 0.99
111_L 166_I 1.3 0.99
5_L 74_D 1.287 0.99
43_L 232_R 1.276 0.99
59_M 66_P 1.275 0.99
8_V 35_F 1.273 0.99
77_P 80_F 1.253 0.99
110_I 163_R 1.242 0.98
194_L 197_Q 1.242 0.98
174_A 193_M 1.228 0.98
140_L 144_V 1.211 0.98
106_R 109_Q 1.209 0.98
9_R 34_S 1.206 0.98
42_T 197_Q 1.201 0.98
129_Q 133_T 1.197 0.98
133_T 166_I 1.183 0.98
168_R 200_Q 1.171 0.98
57_A 173_I 1.167 0.97
131_I 135_R 1.156 0.97
107_I 159_L 1.155 0.97
42_T 204_Y 1.153 0.97
11_L 66_P 1.152 0.97
60_L 205_I 1.14 0.97
192_L 195_E 1.139 0.97
197_Q 204_Y 1.133 0.97
56_L 224_M 1.126 0.97
112_D 127_R 1.124 0.97
105_Q 109_Q 1.123 0.97
186_R 213_M 1.115 0.96
61_A 92_M 1.109 0.96
38_R 220_Q 1.108 0.96
111_L 134_M 1.103 0.96
190_I 213_M 1.091 0.96
174_A 204_Y 1.09 0.96
39_E 74_D 1.086 0.96
8_V 56_L 1.081 0.95
33_L 56_L 1.081 0.95
230_V 244_H 1.071 0.95
93_I 161_L 1.064 0.95
132_E 135_R 1.063 0.95
172_I 204_Y 1.056 0.95
244_H 247_T 1.053 0.95
143_H 155_Q 1.048 0.94
13_K 55_T 1.046 0.94
43_L 220_Q 1.038 0.94
125_Q 128_K 1.037 0.94
170_K 202_I 1.03 0.94
137_V 162_A 1.026 0.94
61_A 173_I 1.024 0.93
59_M 71_L 1.022 0.93
109_Q 112_D 1.022 0.93
4_T 38_R 1.021 0.93
93_I 174_A 1.019 0.93
151_L 159_L 1.012 0.93
58_K 64_I 1.006 0.93
134_M 139_L 1.003 0.93
35_F 56_L 1.003 0.93
76_H 89_R 1.003 0.93
131_I 140_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiC40.9664100-0.006Contact Map0.894
1v43A10.9441000.01Contact Map0.826
2it1A20.93661000.012Contact Map0.877
1g29120.9441000.014Contact Map0.905
2yyzA10.93661000.015Contact Map0.818
1oxxK10.95151000.016Contact Map0.811
3rlfA20.93661000.019Contact Map0.85
3fvqA20.94781000.022Contact Map0.787
1z47A20.94781000.028Contact Map0.849
4fwiB10.97761000.033Contact Map0.742

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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