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ACYP - Acylphosphatase
UniProt: P0AB65 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13726
Length: 92 (90)
Sequences: 2044
Seq/Len: 22.71

ACYP
Paralog alert: 0.35 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
11_Y 43_S 2.537 1.00
9_W 43_S 2.447 1.00
26_E 29_R 2.366 1.00
24_Q 28_K 2.328 1.00
48_A 58_L 2.28 1.00
18_G 21_Y 2.257 1.00
5_C 49_C 2.194 1.00
22_T 61_W 2.147 1.00
11_Y 74_R 2.128 1.00
39_L 45_E 2.115 1.00
37_K 45_E 2.089 1.00
8_A 59_M 2.073 1.00
67_P 70_A 1.889 1.00
49_C 84_G 1.878 1.00
23_T 62_L 1.773 1.00
5_C 47_V 1.737 1.00
9_W 39_L 1.689 1.00
35_Y 92_R 1.64 1.00
32_L 48_A 1.621 1.00
30_L 61_W 1.614 1.00
61_W 65_G 1.593 1.00
35_Y 47_V 1.577 1.00
7_I 45_E 1.508 1.00
52_E 56_E 1.366 0.99
33_T 88_D 1.358 0.99
66_G 70_A 1.339 0.99
59_M 77_S 1.321 0.99
8_A 46_V 1.295 0.99
6_I 79_P 1.281 0.99
48_A 55_V 1.277 0.99
48_A 62_L 1.258 0.99
10_V 75_V 1.23 0.98
29_R 61_W 1.18 0.98
8_A 62_L 1.178 0.98
11_Y 76_L 1.152 0.97
32_L 50_G 1.115 0.96
49_C 85_E 1.103 0.96
51_E 54_Q 1.1 0.96
30_L 54_Q 1.078 0.95
33_T 49_C 1.075 0.95
57_K 60_Q 1.07 0.95
10_V 46_V 1.056 0.95
39_L 43_S 1.051 0.94
6_I 77_S 1.036 0.94
17_V 20_R 1.019 0.93
24_Q 91_I 1.015 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hi1A30.98911000.04Contact Map0.769
4g9iA60.96741000.041Contact Map0.866
2gv1A111000.043Contact Map0.55
1w2iA20.97831000.053Contact Map0.882
3trgA10.97831000.055Contact Map0.785
3vthA20.97831000.058Contact Map0.915
2bjdA20.98911000.06Contact Map0.886
2fhmA10.96741000.06Contact Map0.75
2lxfA10.97831000.064Contact Map0.655
1ulrA10.95651000.068Contact Map0.783

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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