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ALF - Fructose-bisphosphate aldolase class 2
UniProt: P0AB71 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10282
Length: 359 (337)
Sequences: 1806
Seq/Len: 5.36

ALF
Paralog alert: 0.35 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ALF GATY KBAY YDJI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
205_Y 209_E 4.15 1.00
52_K 343_I 4.145 1.00
151_L 205_Y 3.821 1.00
160_K 163_E 3.779 1.00
55_A 355_A 3.639 1.00
52_K 347_E 3.458 1.00
302_N 306_A 3.183 1.00
243_R 247_E 2.949 1.00
24_V 30_F 2.934 1.00
238_T 241_I 2.879 1.00
48_E 343_I 2.761 1.00
24_V 28_N 2.696 1.00
53_V 351_Q 2.672 1.00
204_D 208_T 2.608 1.00
46_V 57_V 2.592 1.00
150_S 153_E 2.578 1.00
156_E 160_K 2.443 1.00
272_A 352_E 2.317 1.00
51_A 102_G 2.311 1.00
223_F 242_L 2.299 1.00
61_F 139_F 2.24 1.00
351_Q 356_I 2.231 1.00
144_I 157_I 2.147 1.00
243_R 277_D 2.136 1.00
271_T 274_E 2.111 1.00
340_T 344_A 2.11 1.00
337_A 340_T 2.077 1.00
299_G 341_S 2.075 1.00
121_D 164_R 2.039 1.00
244_D 247_E 2.024 1.00
151_L 155_I 2.007 1.00
23_Q 27_E 1.969 1.00
159_S 163_E 1.942 1.00
53_V 356_I 1.918 1.00
19_Q 23_Q 1.895 1.00
18_V 106_I 1.886 1.00
21_V 106_I 1.852 1.00
53_V 347_E 1.837 1.00
277_D 280_S 1.827 1.00
243_R 281_Y 1.793 1.00
204_D 248_Y 1.78 1.00
300_V 334_W 1.78 1.00
44_N 339_Q 1.768 1.00
34_A 60_Q 1.749 1.00
146_L 149_E 1.739 1.00
163_E 167_K 1.703 1.00
343_I 347_E 1.695 1.00
121_D 125_D 1.694 1.00
202_D 205_Y 1.685 1.00
92_H 96_Q 1.682 1.00
125_D 164_R 1.673 1.00
344_A 347_E 1.668 1.00
151_L 202_D 1.644 0.99
262_F 283_V 1.637 0.99
166_S 217_F 1.622 0.99
159_S 209_E 1.622 0.99
239_P 277_D 1.614 0.99
350_F 356_I 1.608 0.99
37_C 59_V 1.603 0.99
201_E 248_Y 1.584 0.99
152_Q 209_E 1.582 0.99
164_R 168_I 1.582 0.99
277_D 281_Y 1.55 0.99
92_H 95_H 1.504 0.99
94_V 107_L 1.504 0.99
18_V 218_T 1.498 0.99
166_S 169_G 1.493 0.99
272_A 276_K 1.484 0.99
181_G 184_D 1.467 0.98
26_K 284_V 1.458 0.98
299_G 302_N 1.457 0.98
341_S 344_A 1.456 0.98
305_K 308_E 1.45 0.98
128_E 164_R 1.438 0.98
250_S 257_H 1.432 0.98
47_L 105_V 1.419 0.98
26_K 246_Q 1.396 0.98
328_Y 333_V 1.393 0.98
57_V 105_V 1.383 0.98
151_L 209_E 1.377 0.97
199_Q 202_D 1.375 0.97
298_E 302_N 1.371 0.97
181_G 186_V 1.362 0.97
289_D 293_Q 1.359 0.97
161_Y 172_L 1.354 0.97
51_A 54_K 1.341 0.97
28_N 358_V 1.337 0.97
225_N 270_S 1.335 0.97
43_I 59_V 1.325 0.97
142_H 165_M 1.323 0.96
250_S 255_L 1.322 0.96
307_N 327_K 1.311 0.96
280_S 354_N 1.297 0.96
125_D 168_I 1.295 0.96
29_N 280_S 1.283 0.96
37_C 43_I 1.279 0.96
344_A 348_K 1.274 0.95
127_G 138_L 1.273 0.95
33_P 346_L 1.271 0.95
240_T 244_D 1.266 0.95
96_Q 99_E 1.265 0.95
48_E 339_Q 1.263 0.95
38_V 42_S 1.256 0.95
208_T 252_K 1.256 0.95
239_P 281_Y 1.256 0.95
149_E 153_E 1.253 0.95
152_Q 205_Y 1.252 0.95
303_Y 307_N 1.251 0.95
292_T 342_M 1.247 0.95
204_D 253_H 1.238 0.94
124_L 170_M 1.227 0.94
33_P 342_M 1.224 0.94
174_I 212_K 1.215 0.94
64_G 332_R 1.21 0.93
47_L 101_Y 1.207 0.93
129_K 133_A 1.206 0.93
51_A 101_Y 1.202 0.93
153_E 156_E 1.192 0.93
296_T 335_L 1.188 0.93
158_C 174_I 1.18 0.92
20_K 24_V 1.179 0.92
279_V 353_L 1.168 0.92
162_L 172_L 1.165 0.92
62_S 289_D 1.15 0.91
43_I 97_M 1.145 0.91
178_C 241_I 1.136 0.90
245_S 262_F 1.132 0.90
200_P 248_Y 1.127 0.90
348_K 352_E 1.126 0.90
304_Y 334_W 1.122 0.90
250_S 256_P 1.112 0.89
157_I 160_K 1.101 0.88
61_F 90_G 1.099 0.88
142_H 172_L 1.098 0.88
272_A 348_K 1.092 0.88
62_S 332_R 1.085 0.87
158_C 162_L 1.084 0.87
276_K 352_E 1.083 0.87
37_C 46_V 1.08 0.87
50_A 350_F 1.08 0.87
63_N 119_W 1.079 0.87
130_H 134_T 1.069 0.86
149_E 157_I 1.062 0.86
240_T 243_R 1.055 0.85
152_Q 156_E 1.054 0.85
155_I 209_E 1.051 0.85
355_A 358_V 1.049 0.85
65_G 289_D 1.048 0.85
108_H 141_S 1.046 0.85
198_T 221_A 1.044 0.84
319_K 323_Q 1.041 0.84
242_L 283_V 1.04 0.84
41_D 296_T 1.03 0.83
347_E 351_Q 1.029 0.83
43_I 69_I 1.026 0.83
244_D 248_Y 1.025 0.83
56_P 104_P 1.019 0.82
276_K 354_N 1.017 0.82
33_P 353_L 1.015 0.82
247_E 251_K 1.014 0.82
33_P 350_F 1.009 0.82
345_R 348_K 1.008 0.82
142_H 170_M 1.004 0.81
49_T 53_V 1.001 0.81
307_N 328_Y 1.001 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1dosA20.99721000.103Contact Map0.721
3qm3A80.98331000.112Contact Map0.725
3elfA10.93041000.183Contact Map0.645
1gvfA20.79111000.201Contact Map0.722
3n9rA80.79111000.201Contact Map0.785
1rvgA40.78831000.204Contact Map0.816
3q94A20.79671000.204Contact Map0.79
2iswA20.78551000.208Contact Map0.768
3pm6A20.81891000.235Contact Map0.776
3txvA10.82731000.376Contact Map0.297

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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