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AROG - Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
UniProt: P0AB91 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10079
Length: 350 (346)
Sequences: 1125
Seq/Len: 3.25

AROG
Paralog alert: 0.71 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: AROF AROG AROH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
242_S 245_H 5.618 1.00
82_E 339_R 4.35 1.00
112_H 121_D 4.306 1.00
71_E 305_L 4.144 1.00
45_K 50_N 3.894 1.00
306_V 322_K 3.346 1.00
319_A 322_K 3.345 1.00
81_E 84_K 3.208 1.00
25_K 124_R 3.126 1.00
307_E 330_G 3.036 1.00
58_I 334_T 3.002 1.00
329_I 337_L 2.979 1.00
77_L 81_E 2.915 1.00
83_L 339_R 2.896 1.00
86_E 346_K 2.821 1.00
306_V 319_A 2.82 1.00
330_G 333_D 2.765 1.00
113_M 324_I 2.742 1.00
276_K 307_E 2.697 1.00
283_A 340_Q 2.57 1.00
128_K 132_D 2.511 1.00
69_A 129_L 2.501 1.00
275_F 327_A 2.435 1.00
246_V 264_I 2.428 1.00
46_I 88_E 2.403 1.00
254_N 260_A 2.233 1.00
42_A 88_E 2.22 1.00
26_F 131_L 2.19 1.00
38_H 42_A 2.148 1.00
284_D 287_Q 2.141 1.00
118_Q 121_D 2.135 1.00
312_L 324_I 2.097 1.00
277_K 280_D 2.084 1.00
43_I 90_V 2.017 1.00
112_H 118_Q 1.979 1.00
275_F 307_E 1.928 1.00
71_E 320_Y 1.912 1.00
48_K 228_D 1.898 0.99
129_L 133_I 1.897 0.99
80_R 88_E 1.875 0.99
192_T 195_V 1.822 0.99
56_V 299_V 1.819 0.99
67_V 74_T 1.795 0.99
264_I 285_V 1.761 0.99
266_F 282_C 1.747 0.99
159_W 230_H 1.689 0.99
34_N 38_H 1.686 0.99
41_K 45_K 1.666 0.98
74_T 136_S 1.664 0.98
58_I 301_V 1.658 0.98
243_A 291_G 1.657 0.98
250_K 295_A 1.652 0.98
341_L 345_V 1.649 0.98
276_K 333_D 1.634 0.98
250_K 293_E 1.61 0.98
142_G 157_M 1.586 0.98
86_E 342_A 1.574 0.97
73_A 133_I 1.57 0.97
239_P 245_H 1.563 0.97
35_T 39_A 1.562 0.97
57_V 263_M 1.561 0.97
79_L 335_D 1.552 0.97
247_A 251_E 1.523 0.97
75_R 305_L 1.513 0.97
282_C 337_L 1.511 0.96
83_L 338_L 1.492 0.96
71_E 75_R 1.491 0.96
32_A 134_N 1.489 0.96
55_L 90_V 1.459 0.95
335_D 339_R 1.453 0.95
243_A 284_D 1.448 0.95
32_A 35_T 1.433 0.95
7_D 10_I 1.432 0.95
66_P 70_K 1.431 0.95
70_K 74_T 1.426 0.95
313_E 316_E 1.425 0.95
56_V 338_L 1.418 0.94
279_M 333_D 1.414 0.94
31_N 135_D 1.412 0.94
274_Q 277_K 1.388 0.94
244_K 248_E 1.387 0.94
301_V 329_I 1.384 0.93
160_G 198_D 1.354 0.92
151_Q 180_S 1.322 0.91
248_E 252_G 1.317 0.91
332_E 335_D 1.301 0.90
213_T 219_A 1.295 0.90
180_S 209_F 1.293 0.90
79_L 339_R 1.289 0.90
5_N 8_L 1.286 0.90
71_E 74_T 1.286 0.90
79_L 83_L 1.284 0.90
342_A 346_K 1.272 0.89
79_L 82_E 1.271 0.89
44_H 228_D 1.268 0.89
286_C 341_L 1.26 0.88
301_V 337_L 1.255 0.88
95_F 130_L 1.254 0.88
239_P 242_S 1.24 0.87
75_R 331_W 1.238 0.87
134_N 140_A 1.227 0.87
307_E 333_D 1.225 0.86
17_L 120_N 1.217 0.86
21_A 24_E 1.203 0.85
200_I 231_I 1.203 0.85
41_K 44_H 1.202 0.85
69_A 133_I 1.201 0.85
261_Q 297_I 1.188 0.84
286_C 340_Q 1.188 0.84
83_L 89_I 1.186 0.84
211_S 221_V 1.176 0.83
286_C 345_V 1.17 0.83
22_L 123_L 1.162 0.82
70_K 136_S 1.157 0.82
263_M 297_I 1.156 0.82
330_G 336_A 1.155 0.82
75_R 79_L 1.154 0.82
243_A 247_A 1.154 0.82
282_C 299_V 1.151 0.81
82_E 335_D 1.149 0.81
11_K 224_S 1.144 0.81
108_I 126_A 1.125 0.79
74_T 78_A 1.123 0.79
194_K 198_D 1.12 0.79
20_V 215_W 1.116 0.79
243_A 287_Q 1.115 0.79
6_D 214_K 1.108 0.78
251_E 255_K 1.102 0.77
249_V 262_V 1.101 0.77
29_T 135_D 1.1 0.77
147_M 171_V 1.098 0.77
188_G 192_T 1.097 0.77
95_F 126_A 1.095 0.77
39_A 43_I 1.087 0.76
15_E 21_A 1.085 0.76
150_P 180_S 1.079 0.75
274_Q 279_M 1.074 0.75
194_K 252_G 1.072 0.75
15_E 217_H 1.069 0.74
275_F 330_G 1.062 0.74
252_G 255_K 1.056 0.73
83_L 342_A 1.052 0.73
56_V 87_L 1.048 0.72
68_A 320_Y 1.047 0.72
42_A 45_K 1.045 0.72
107_L 125_I 1.04 0.71
271_S 327_A 1.031 0.70
47_L 261_Q 1.03 0.70
179_L 183_V 1.024 0.70
247_A 295_A 1.023 0.70
167_T 185_F 1.021 0.69
17_L 22_L 1.017 0.69
121_D 125_I 1.012 0.68
200_I 229_C 1.01 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1of8A20.99431000.198Contact Map0.757
1n8fA411000.202Contact Map0.797
4hsnA40.98861000.237Contact Map0.77
3tqkA10.98571000.241Contact Map0.723
2nwrA20.70571000.677Contact Map0.583
4lu0A40.77431000.677Contact Map0.56
1o60A40.74571000.703Contact Map0.571
1vs1A40.76571000.705Contact Map0.479
2qkfA40.72861000.712Contact Map0.546
3fs2A20.81141000.714Contact Map0.527

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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