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ARSC - Arsenate reductase
UniProt: P0AB96 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12237
Length: 141 (122)
Sequences: 2179
Seq/Len: 17.86

ARSC
Paralog alert: 0.78 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: ARSC YFFB YFGD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_H 36_E 3.638 1.00
41_R 83_D 3.165 1.00
85_M 92_I 3.152 1.00
23_R 29_P 2.72 1.00
77_T 80_R 2.51 1.00
40_T 43_E 2.389 1.00
46_K 50_D 2.318 1.00
41_R 45_V 2.145 1.00
48_I 82_I 2.112 1.00
8_H 31_I 1.912 1.00
70_G 73_E 1.827 1.00
6_I 97_V 1.784 1.00
55_V 78_D 1.776 1.00
35_L 90_I 1.764 1.00
6_I 19_L 1.754 1.00
48_I 58_L 1.721 1.00
76_F 84_F 1.661 1.00
83_D 87_Q 1.649 1.00
5_T 30_T 1.633 1.00
64_E 68_E 1.628 1.00
111_V 114_E 1.559 1.00
41_R 82_I 1.559 1.00
23_R 28_E 1.545 1.00
21_M 25_S 1.54 1.00
65_P 88_H 1.538 1.00
99_T 102_G 1.517 1.00
24_N 120_Q 1.516 1.00
51_M 58_L 1.489 1.00
53_I 58_L 1.464 1.00
20_E 24_N 1.451 1.00
45_V 82_I 1.433 1.00
97_V 112_V 1.377 0.99
48_I 52_G 1.364 0.99
19_L 31_I 1.364 0.99
51_M 96_I 1.361 0.99
39_P 92_I 1.313 0.99
32_I 43_E 1.271 0.99
50_D 103_T 1.258 0.99
14_T 17_N 1.219 0.98
54_S 57_A 1.203 0.98
59_L 81_L 1.203 0.98
42_D 45_V 1.203 0.98
43_E 46_K 1.192 0.98
58_L 96_I 1.19 0.98
47_L 98_V 1.168 0.97
32_I 37_T 1.15 0.97
45_V 79_D 1.144 0.97
8_H 19_L 1.123 0.97
104_R 115_I 1.12 0.96
47_L 96_I 1.118 0.96
15_S 34_Y 1.114 0.96
32_I 38_P 1.112 0.96
63_V 90_I 1.108 0.96
7_Y 32_I 1.107 0.96
8_H 15_S 1.086 0.96
43_E 98_V 1.079 0.95
120_Q 123_A 1.077 0.95
112_V 116_L 1.068 0.95
7_Y 47_L 1.065 0.95
41_R 86_L 1.061 0.95
55_V 81_L 1.046 0.94
56_R 66_Y 1.04 0.94
9_N 15_S 1.037 0.94
44_L 82_I 1.035 0.94
24_N 121_K 1.035 0.94
45_V 78_D 1.034 0.94
65_P 68_E 1.028 0.94
48_I 55_V 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1s3cA111000.218Contact Map0.84
1z3eA10.93621000.315Contact Map0.774
3gkxA20.82271000.327Contact Map0.809
3f0iA20.82271000.33Contact Map0.849
3l78A10.85111000.331Contact Map0.659
3fz4A10.82271000.333Contact Map0.724
2m46A10.83691000.336Contact Map0.738
2kokA10.82271000.339Contact Map0.467
3rdwA20.82981000.339Contact Map0.845
1rw1A10.80141000.362Contact Map0.778

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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