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ACCA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
UniProt: P0ABD5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11647
Length: 319 (315)
Sequences: 1205
Seq/Len: 3.83

ACCA
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
103_G 146_L 3.972 1.00
83_F 106_A 3.817 1.00
197_C 214_G 3.743 1.00
111_R 298_D 3.412 1.00
301_S 304_D 3.224 1.00
161_I 212_G 2.799 1.00
109_D 287_K 2.763 1.00
147_M 188_M 2.721 1.00
266_S 292_A 2.721 1.00
81_L 280_E 2.601 1.00
220_L 282_M 2.545 1.00
144_L 184_N 2.449 1.00
215_D 308_R 2.448 1.00
151_E 192_G 2.431 1.00
278_N 281_A 2.35 1.00
63_I 222_Y 2.344 1.00
179_E 183_R 2.339 1.00
268_I 286_L 2.3 1.00
300_L 308_R 2.284 1.00
218_N 289_Q 2.271 1.00
243_K 246_L 2.151 1.00
108_L 291_L 2.056 1.00
81_L 283_A 2.053 1.00
114_M 155_M 2.04 1.00
76_L 119_Q 2.037 1.00
82_A 108_L 2.036 1.00
228_I 232_G 2.031 1.00
148_Q 187_E 2.029 1.00
264_I 267_I 1.964 1.00
302_T 306_K 1.889 1.00
99_K 129_R 1.885 1.00
114_M 149_M 1.884 1.00
105_I 155_M 1.872 1.00
307_N 311_Q 1.855 1.00
75_T 118_H 1.839 1.00
75_T 117_G 1.799 0.99
82_A 287_K 1.792 0.99
158_I 198_T 1.781 0.99
218_N 293_D 1.766 0.99
109_D 291_L 1.758 0.99
266_S 293_D 1.757 0.99
76_L 102_V 1.746 0.99
23_T 44_R 1.738 0.99
215_D 306_K 1.727 0.99
114_M 146_L 1.703 0.99
144_L 187_E 1.68 0.99
95_Y 175_R 1.663 0.99
233_C 251_M 1.662 0.99
192_G 303_E 1.551 0.98
161_I 197_C 1.55 0.98
293_D 296_D 1.54 0.98
138_E 175_R 1.534 0.98
215_D 302_T 1.531 0.98
147_M 191_L 1.523 0.98
111_R 295_A 1.507 0.97
90_A 97_D 1.491 0.97
149_M 155_M 1.485 0.97
312_R 316_Y 1.459 0.97
310_Y 314_M 1.457 0.97
216_K 296_D 1.448 0.97
219_M 264_I 1.435 0.96
113_V 158_I 1.415 0.96
122_R 126_E 1.41 0.96
212_G 217_V 1.41 0.96
74_Y 119_Q 1.392 0.95
83_F 115_I 1.388 0.95
282_M 286_L 1.377 0.95
69_H 276_H 1.375 0.95
259_K 264_I 1.374 0.95
157_I 193_V 1.367 0.95
124_T 128_I 1.366 0.95
83_F 108_L 1.365 0.95
108_L 287_K 1.364 0.95
49_E 53_K 1.363 0.95
266_S 289_Q 1.362 0.95
171_G 174_E 1.347 0.94
218_N 266_S 1.347 0.94
136_A 171_G 1.345 0.94
98_D 139_G 1.344 0.94
101_I 211_I 1.336 0.94
184_N 187_E 1.333 0.94
113_V 294_L 1.333 0.94
216_K 308_R 1.325 0.93
131_N 134_M 1.319 0.93
228_I 233_C 1.316 0.93
119_Q 130_R 1.313 0.93
105_I 114_M 1.313 0.93
95_Y 138_E 1.307 0.93
59_G 62_Q 1.298 0.93
183_R 187_E 1.291 0.92
191_L 195_V 1.291 0.92
252_G 257_R 1.29 0.92
204_G 210_A 1.289 0.92
63_I 256_P 1.287 0.92
154_K 193_V 1.277 0.92
216_K 293_D 1.275 0.92
167_Y 171_G 1.273 0.92
188_M 195_V 1.264 0.91
38_E 42_R 1.261 0.91
77_D 122_R 1.259 0.91
75_T 79_V 1.256 0.91
82_A 283_A 1.255 0.91
151_E 191_L 1.25 0.91
84_D 107_R 1.246 0.90
172_A 177_Q 1.215 0.89
120_K 164_P 1.209 0.89
287_K 291_L 1.203 0.88
160_F 198_T 1.2 0.88
218_N 268_I 1.195 0.88
215_D 305_L 1.185 0.87
281_A 285_S 1.18 0.87
134_M 164_P 1.174 0.87
95_Y 171_G 1.169 0.86
106_A 115_I 1.162 0.86
64_A 224_T 1.146 0.85
135_P 210_A 1.14 0.84
217_V 264_I 1.14 0.84
171_G 175_R 1.121 0.83
300_L 304_D 1.119 0.83
84_D 110_G 1.118 0.83
64_A 253_I 1.116 0.83
288_A 292_A 1.11 0.82
39_E 42_R 1.101 0.81
103_G 114_M 1.097 0.81
119_Q 127_K 1.095 0.81
112_P 155_M 1.095 0.81
313_L 316_Y 1.092 0.81
58_L 271_P 1.084 0.80
281_A 284_A 1.084 0.80
157_I 191_L 1.082 0.80
204_G 224_T 1.078 0.79
101_I 135_P 1.077 0.79
81_L 279_P 1.076 0.79
82_A 160_F 1.074 0.79
297_L 305_L 1.074 0.79
192_G 302_T 1.072 0.79
193_V 255_A 1.07 0.79
233_C 250_A 1.069 0.79
8_F 11_P 1.054 0.77
196_V 290_L 1.042 0.76
198_T 286_L 1.039 0.76
108_L 290_L 1.031 0.75
24_A 27_R 1.029 0.75
6_L 9_E 1.018 0.74
215_D 301_S 1.016 0.74
10_Q 13_A 1.015 0.73
214_G 217_V 1.006 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2f9yA111000.437Contact Map0.814
2f9iA20.99061000.459Contact Map0.802
3n6rB60.89971000.621Contact Map0.675
1vrgA60.88711000.628Contact Map0.71
3iavA20.89661000.631Contact Map0.654
1on3A60.89031000.646Contact Map0.712
1x0uA60.89031000.657Contact Map0.709
1pixA20.91851000.66Contact Map0.61
3gf3A10.93731000.663Contact Map0.523
2bzrA60.89661000.663Contact Map0.711

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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