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BCCP - Biotin carboxyl carrier protein of acetyl-CoA carboxylase
UniProt: P0ABD8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10275
Length: 156 (155)
Sequences: 1448
Seq/Len: 9.34

BCCP
Paralog alert: 0.08 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
24_S 29_S 4.739 1.00
111_V 132_S 3.368 1.00
93_R 104_E 3.189 1.00
84_R 149_D 3.129 1.00
104_E 107_Q 2.929 1.00
117_I 124_M 2.861 1.00
108_K 134_T 2.514 1.00
22_E 31_R 2.383 1.00
141_E 144_Q 2.37 1.00
94_T 142_S 2.257 1.00
110_N 132_S 2.241 1.00
134_T 156_E 2.219 1.00
81_H 130_D 2.121 1.00
136_K 156_E 2.106 1.00
137_A 154_V 2.08 1.00
2_D 5_K 2.068 1.00
20_E 33_S 1.946 1.00
96_S 99_A 1.894 1.00
14_E 17_G 1.882 1.00
100_K 104_E 1.865 1.00
139_L 151_P 1.823 1.00
105_V 137_A 1.802 1.00
107_Q 113_D 1.793 1.00
83_V 115_L 1.779 1.00
82_I 154_V 1.772 1.00
85_S 118_V 1.709 1.00
123_M 149_D 1.658 1.00
81_H 131_K 1.642 1.00
94_T 101_A 1.59 1.00
13_V 21_L 1.573 1.00
103_I 153_V 1.562 1.00
133_G 155_I 1.555 1.00
110_N 113_D 1.54 1.00
13_V 32_I 1.469 1.00
88_V 148_F 1.432 0.99
91_F 116_C 1.429 0.99
83_V 155_I 1.407 0.99
82_I 151_P 1.36 0.99
4_R 8_K 1.335 0.99
10_I 32_I 1.31 0.99
115_L 153_V 1.294 0.99
116_C 153_V 1.259 0.98
140_V 150_E 1.254 0.98
103_I 138_I 1.241 0.98
13_V 123_M 1.22 0.98
123_M 128_E 1.184 0.97
8_K 11_E 1.176 0.97
138_I 153_V 1.174 0.97
12_L 30_V 1.156 0.97
1_M 7_K 1.143 0.97
135_V 153_V 1.14 0.96
111_V 129_A 1.132 0.96
85_S 125_N 1.128 0.96
10_I 18_I 1.127 0.96
103_I 135_V 1.117 0.96
95_P 99_A 1.088 0.95
136_K 154_V 1.077 0.95
22_E 29_S 1.068 0.94
112_G 129_A 1.065 0.94
131_K 155_I 1.059 0.94
10_I 13_V 1.044 0.93
147_E 150_E 1.041 0.93
112_G 115_L 1.036 0.93
18_I 32_I 1.033 0.93
13_V 18_I 1.031 0.93
24_S 27_E 1.017 0.92
7_K 12_L 1.016 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hr7B40.99361000.267Contact Map0.865
3va7A10.935999.80.599Contact Map0.576
2qf7A20.833399.80.622Contact Map0.606
3hblA40.788599.80.624Contact Map0.796
3bg3A40.929599.70.638Contact Map0.731
3hgbA10.698799.70.654Contact Map0.441
3n6rA60.929599.60.66Contact Map0.798
3mxuA10.685999.60.661Contact Map0.486
3tzuA40.673199.60.662Contact Map0.49
1bdoA10.512899.60.662Contact Map0.808

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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