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CYNT - Carbonic anhydrase 1
UniProt: P0ABE9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10176
Length: 219 (202)
Sequences: 1827
Seq/Len: 9.04

CYNT
Paralog alert: 0.42 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: CAN CYNT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
153_V 179_G 4.309 1.00
161_Q 170_L 4.062 1.00
33_R 91_S 3.678 1.00
64_G 103_A 2.97 1.00
157_L 179_G 2.821 1.00
2_K 6_D 2.513 1.00
82_E 86_A 2.402 1.00
92_D 178_H 2.399 1.00
63_A 80_S 2.323 1.00
30_Q 42_S 2.311 1.00
167_R 171_E 2.29 1.00
168_L 172_E 2.2 1.00
35_L 81_V 2.16 1.00
157_L 177_L 2.136 1.00
149_V 181_V 2.08 1.00
99_S 181_V 1.902 1.00
84_A 90_V 1.895 1.00
85_V 169_A 1.883 1.00
5_I 191_A 1.78 1.00
78_S 163_H 1.756 1.00
9_L 13_R 1.75 1.00
169_A 174_R 1.729 1.00
9_L 188_S 1.726 1.00
89_R 169_A 1.715 1.00
150_R 190_A 1.703 1.00
166_V 175_I 1.6 1.00
6_D 10_K 1.57 1.00
140_D 143_S 1.558 1.00
10_K 51_Q 1.557 1.00
193_D 200_V 1.543 1.00
94_V 180_W 1.534 1.00
153_V 157_L 1.526 1.00
145_A 149_V 1.518 1.00
50_T 57_L 1.505 1.00
125_Y 128_S 1.501 1.00
65_N 152_N 1.492 1.00
83_Y 102_G 1.484 1.00
161_Q 177_L 1.478 1.00
60_I 80_S 1.477 1.00
180_W 189_I 1.477 1.00
183_D 186_S 1.459 1.00
81_V 160_L 1.426 0.99
36_F 96_C 1.414 0.99
108_A 148_M 1.405 0.99
183_D 190_A 1.38 0.99
7_G 11_F 1.35 0.99
159_N 162_T 1.342 0.99
35_L 80_S 1.329 0.99
105_T 109_S 1.328 0.99
40_S 58_F 1.319 0.99
14_E 18_K 1.304 0.99
105_T 145_A 1.303 0.99
29_Q 100_N 1.288 0.99
150_R 181_V 1.276 0.98
71_G 74_P 1.276 0.98
107_I 126_A 1.258 0.98
71_G 75_G 1.253 0.98
35_L 90_V 1.248 0.98
50_T 96_C 1.248 0.98
24_K 27_A 1.242 0.98
85_V 166_V 1.213 0.98
36_F 50_T 1.196 0.97
35_L 93_I 1.193 0.97
40_S 60_I 1.188 0.97
126_A 129_A 1.174 0.97
85_V 90_V 1.167 0.97
100_N 185_E 1.155 0.97
40_S 88_L 1.153 0.97
92_D 176_A 1.143 0.96
62_N 65_N 1.124 0.96
102_G 119_V 1.122 0.96
91_S 174_R 1.121 0.96
83_Y 87_A 1.12 0.96
44_L 59_V 1.118 0.96
7_G 51_Q 1.104 0.95
151_E 154_I 1.096 0.95
136_R 147_A 1.09 0.95
96_C 180_W 1.09 0.95
30_Q 102_G 1.087 0.95
22_L 25_Q 1.073 0.94
99_S 183_D 1.072 0.94
153_V 181_V 1.063 0.94
133_N 136_R 1.042 0.93
180_W 191_A 1.042 0.93
52_R 56_D 1.038 0.93
165_S 168_L 1.035 0.93
140_D 144_K 1.035 0.93
19_R 53_E 1.032 0.93
12_Q 16_F 1.021 0.92
97_G 153_V 1.021 0.92
141_L 144_K 1.019 0.92
59_V 62_N 1.019 0.92
142_P 146_A 1.016 0.92
63_A 103_A 1.012 0.92
38_S 96_C 1.001 0.91
31_S 89_R 1.001 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ddzA20.97261000.204Contact Map0.638
3qy1A20.9681000.205Contact Map0.775
2w3qA10.91321000.208Contact Map0.652
3e3iA120.97261000.21Contact Map0.732
1ekjA80.93151000.217Contact Map0.758
3eyxA20.89951000.231Contact Map0.736
3ucjA20.94521000.239Contact Map0.763
1ym3A10.87671000.242Contact Map0.597
3vqjA10.87671000.262Contact Map0.558
3teoA160.87211000.334Contact Map0.737

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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