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CLPA - ATP-dependent Clp protease ATP-binding subunit ClpA
UniProt: P0ABH9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10156
Length: 758 (745)
Sequences: 3419
Seq/Len: 4.59

CLPA
Paralog alert: 0.89 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CLPA CLPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
178_Q 182_V 6.346 1.00
683_S 734_A 6.035 1.00
175_N 244_T 5.301 1.00
663_D 687_R 5.118 1.00
354_T 382_V 4.936 1.00
659_H 688_N 4.468 1.00
719_E 724_S 4.377 1.00
655_T 692_E 4.244 1.00
685_E 734_A 4.231 1.00
173_T 246_Y 4.203 1.00
351_I 382_V 3.711 1.00
455_R 458_M 3.67 1.00
457_K 464_D 3.476 1.00
585_T 593_K 3.431 1.00
451_N 454_D 3.303 1.00
201_V 344_I 3.198 1.00
275_E 315_K 3.021 1.00
603_M 644_L 2.919 1.00
712_L 733_V 2.908 1.00
683_S 732_T 2.838 1.00
251_G 306_L 2.766 1.00
667_V 670_Q 2.725 1.00
490_S 581_M 2.717 1.00
174_T 179_L 2.705 1.00
453_G 468_E 2.622 1.00
452_L 511_A 2.612 1.00
350_S 353_E 2.578 1.00
681_E 732_T 2.577 1.00
689_W 735_L 2.547 1.00
686_A 742_L 2.538 1.00
57_E 126_K 2.528 1.00
505_T 602_V 2.521 1.00
355_V 378_V 2.512 1.00
655_T 688_N 2.511 1.00
472_E 718_N 2.509 1.00
175_N 178_Q 2.429 1.00
422_N 425_D 2.414 1.00
258_K 262_D 2.363 1.00
492_L 644_L 2.337 1.00
666_I 682_V 2.301 1.00
373_Y 406_G 2.275 1.00
351_I 386_V 2.249 1.00
472_E 714_K 2.247 1.00
198_A 344_I 2.233 1.00
654_S 657_V 2.212 1.00
607_A 632_I 2.206 1.00
689_W 742_L 2.205 1.00
22_H 62_I 2.2 1.00
238_E 241_A 2.15 1.00
517_L 559_A 2.15 1.00
737_K 740_N 2.149 1.00
347_T 556_H 2.112 1.00
443_Q 451_N 2.092 1.00
272_K 275_E 2.09 1.00
632_I 641_R 2.086 1.00
734_A 743_T 2.081 1.00
272_K 276_Q 2.077 1.00
356_Q 359_N 2.059 1.00
528_H 537_P 2.033 1.00
87_V 111_A 2.025 1.00
44_L 49_V 2.019 1.00
492_L 566_I 2.018 1.00
679_S 730_Q 2.015 1.00
580_V 601_L 2.012 1.00
32_L 59_E 2.012 1.00
465_K 651_D 2.01 1.00
725_L 731_V 2.001 1.00
693_K 711_N 1.999 1.00
607_A 635_I 1.986 1.00
459_L 507_Q 1.975 1.00
461_F 664_K 1.973 1.00
250_I 253_L 1.961 1.00
253_L 270_L 1.949 1.00
726_V 729_G 1.943 1.00
736_D 740_N 1.94 1.00
453_G 475_K 1.929 1.00
234_G 241_A 1.928 1.00
681_E 730_Q 1.91 1.00
580_V 586_L 1.908 1.00
659_H 684_Q 1.906 1.00
211_L 287_I 1.884 1.00
57_E 60_A 1.876 1.00
467_I 504_V 1.863 1.00
676_K 727_D 1.84 1.00
716_L 731_V 1.836 1.00
380_A 423_V 1.797 1.00
345_D 556_H 1.796 1.00
30_L 84_F 1.782 1.00
359_N 375_A 1.774 1.00
31_L 120_A 1.773 1.00
690_L 707_V 1.768 1.00
669_L 708_I 1.767 1.00
361_L 364_K 1.752 1.00
689_W 693_K 1.75 1.00
401_V 430_V 1.75 1.00
451_N 455_R 1.742 1.00
484_E 672_Q 1.739 1.00
707_V 711_N 1.738 1.00
131_R 135_V 1.734 1.00
197_R 404_E 1.723 0.99
660_Q 663_D 1.719 0.99
686_A 735_L 1.712 0.99
379_R 383_E 1.71 0.99
658_I 691_A 1.708 0.99
517_L 553_V 1.701 0.99
167_E 170_E 1.692 0.99
6_L 108_V 1.688 0.99
457_K 467_I 1.688 0.99
49_V 54_L 1.683 0.99
693_K 707_V 1.679 0.99
665_F 705_A 1.677 0.99
469_A 648_I 1.676 0.99
528_H 531_S 1.662 0.99
178_Q 181_R 1.659 0.99
525_M 529_T 1.646 0.99
80_P 84_F 1.635 0.99
465_K 625_S 1.633 0.99
242_D 279_N 1.632 0.99
230_R 235_D 1.63 0.99
287_I 331_F 1.63 0.99
527_R 572_D 1.623 0.99
459_L 510_K 1.612 0.99
87_V 112_I 1.61 0.99
381_A 402_I 1.609 0.99
355_V 379_R 1.599 0.99
674_D 679_S 1.599 0.99
409_A 421_V 1.598 0.99
553_V 599_V 1.595 0.99
179_L 184_G 1.593 0.99
170_E 178_Q 1.583 0.99
456_L 460_V 1.581 0.99
455_R 511_A 1.578 0.99
534_I 576_I 1.577 0.99
385_A 394_L 1.574 0.99
185_I 229_W 1.573 0.99
736_D 743_T 1.567 0.99
329_N 545_Q 1.565 0.99
215_E 324_Y 1.561 0.99
662_V 691_A 1.556 0.99
493_F 602_V 1.547 0.99
372_R 420_T 1.54 0.99
682_V 686_A 1.54 0.99
685_E 688_N 1.539 0.99
186_D 205_R 1.538 0.99
284_I 318_V 1.535 0.99
515_E 556_H 1.525 0.98
351_I 383_E 1.49 0.98
662_V 687_R 1.488 0.98
678_V 725_L 1.487 0.98
524_Y 548_L 1.476 0.98
629_M 632_I 1.471 0.98
492_L 632_I 1.469 0.98
459_L 503_E 1.458 0.98
452_L 471_T 1.452 0.98
383_E 675_Q 1.448 0.98
666_I 708_I 1.444 0.98
363_P 367_A 1.443 0.98
229_W 233_Q 1.435 0.97
367_A 370_D 1.432 0.97
665_F 668_E 1.43 0.97
477_A 482_G 1.428 0.97
36_S 55_R 1.427 0.97
385_A 397_K 1.425 0.97
684_Q 688_N 1.425 0.97
736_D 741_E 1.424 0.97
678_V 731_V 1.418 0.97
689_W 711_N 1.399 0.97
683_S 686_A 1.396 0.97
175_N 246_Y 1.387 0.97
677_G 727_D 1.384 0.97
22_H 29_H 1.382 0.97
711_N 741_E 1.382 0.97
494_A 605_T 1.38 0.97
94_H 131_R 1.38 0.97
54_L 123_L 1.375 0.96
464_D 657_V 1.358 0.96
351_I 355_V 1.355 0.96
10_L 88_L 1.353 0.96
46_A 140_H 1.352 0.96
670_Q 674_D 1.35 0.96
659_H 687_R 1.347 0.96
450_K 721_L 1.347 0.96
475_K 718_N 1.341 0.96
516_L 560_V 1.34 0.96
611_E 631_E 1.334 0.96
271_L 310_L 1.334 0.96
291_I 337_L 1.319 0.95
577_L 580_V 1.317 0.95
631_E 634_K 1.316 0.95
682_V 733_V 1.312 0.95
670_Q 680_L 1.303 0.95
651_D 657_V 1.303 0.95
23_E 69_L 1.299 0.95
90_R 115_E 1.298 0.95
82_L 86_R 1.297 0.95
737_K 741_E 1.294 0.94
86_R 115_E 1.293 0.94
274_L 282_L 1.288 0.94
683_S 735_L 1.288 0.94
5_E 8_L 1.285 0.94
686_A 734_A 1.282 0.94
725_L 729_G 1.271 0.94
267_F 270_L 1.267 0.94
519_F 533_L 1.267 0.94
231_I 245_I 1.264 0.94
450_K 722_F 1.264 0.94
685_E 735_L 1.261 0.93
51_L 55_R 1.26 0.93
453_G 471_T 1.259 0.93
715_P 744_Y 1.255 0.93
216_S 338_A 1.252 0.93
378_V 402_I 1.25 0.93
465_K 468_E 1.248 0.93
447_D 451_N 1.248 0.93
449_L 478_R 1.247 0.93
405_A 426_I 1.241 0.93
553_V 596_F 1.239 0.93
671_V 674_D 1.237 0.93
405_A 429_V 1.226 0.92
694_G 704_M 1.226 0.92
734_A 745_G 1.225 0.92
715_P 741_E 1.222 0.92
530_V 573_V 1.218 0.92
719_E 722_F 1.216 0.92
16_R 33_A 1.21 0.91
353_E 356_Q 1.207 0.91
120_A 124_L 1.204 0.91
16_R 20_H 1.203 0.91
689_W 692_E 1.202 0.91
445_D 478_R 1.201 0.91
374_T 377_A 1.197 0.91
32_L 58_L 1.192 0.91
51_L 54_L 1.189 0.91
563_L 580_V 1.188 0.90
16_R 19_E 1.184 0.90
203_C 239_V 1.184 0.90
26_T 81_T 1.182 0.90
425_D 428_S 1.174 0.90
149_Q 152_D 1.173 0.90
525_M 575_N 1.171 0.90
213_V 343_K 1.168 0.89
682_V 687_R 1.167 0.89
28_E 32_L 1.166 0.89
553_V 561_L 1.166 0.89
296_A 301_V 1.165 0.89
121_A 125_R 1.164 0.89
663_D 684_Q 1.164 0.89
582_D 705_A 1.162 0.89
203_C 407_A 1.16 0.89
156_Q 165_G 1.155 0.89
130_S 133_D 1.153 0.89
287_I 320_G 1.148 0.88
177_N 232_V 1.147 0.88
91_A 108_V 1.14 0.88
374_T 422_N 1.135 0.88
94_H 111_A 1.133 0.87
351_I 354_T 1.131 0.87
177_N 180_A 1.128 0.87
711_N 715_P 1.127 0.87
355_V 383_E 1.12 0.87
2_L 6_L 1.119 0.87
158_N 161_E 1.118 0.87
32_L 55_R 1.113 0.86
531_S 534_I 1.111 0.86
197_R 200_Q 1.111 0.86
22_H 66_T 1.102 0.85
179_L 182_V 1.099 0.85
40_A 109_L 1.098 0.85
27_V 87_V 1.094 0.85
61_F 123_L 1.094 0.85
470_L 648_I 1.093 0.85
181_R 244_T 1.091 0.85
526_E 537_P 1.088 0.84
212_L 346_I 1.087 0.84
192_E 230_R 1.084 0.84
612_T 624_N 1.083 0.84
109_L 134_V 1.082 0.84
216_S 393_H 1.08 0.84
90_R 94_H 1.08 0.84
50_D 53_A 1.079 0.84
259_Y 407_A 1.076 0.84
32_L 36_S 1.075 0.83
177_N 185_I 1.074 0.83
229_W 232_V 1.074 0.83
290_I 304_A 1.073 0.83
207_K 400_D 1.072 0.83
200_Q 408_R 1.069 0.83
486_K 705_A 1.067 0.83
355_V 382_V 1.066 0.83
450_K 718_N 1.065 0.83
28_E 61_F 1.064 0.83
626_T 630_E 1.062 0.82
607_A 631_E 1.06 0.82
205_R 481_L 1.059 0.82
543_F 589_N 1.057 0.82
454_D 457_K 1.054 0.82
530_V 576_I 1.046 0.81
12_M 33_A 1.045 0.81
507_Q 510_K 1.044 0.81
688_N 692_E 1.043 0.81
696_D 703_P 1.043 0.81
174_T 275_E 1.041 0.81
690_L 694_G 1.041 0.81
354_T 394_L 1.041 0.81
457_K 468_E 1.04 0.81
476_M 714_K 1.039 0.81
20_H 62_I 1.038 0.80
359_N 379_R 1.037 0.80
659_H 663_D 1.037 0.80
657_V 660_Q 1.032 0.80
55_R 59_E 1.029 0.80
725_L 744_Y 1.028 0.80
563_L 603_M 1.025 0.79
610_R 631_E 1.023 0.79
312_S 316_I 1.022 0.79
17_A 29_H 1.022 0.79
663_D 670_Q 1.02 0.79
483_H 668_E 1.019 0.79
719_E 744_Y 1.017 0.79
94_H 98_S 1.016 0.78
670_Q 679_S 1.016 0.78
239_V 414_V 1.015 0.78
12_M 15_A 1.013 0.78
458_M 667_V 1.011 0.78
532_R 536_A 1.009 0.78
715_P 719_E 1.008 0.78
4_Q 7_E 1.008 0.78
673_L 677_G 1.007 0.78
680_L 712_L 1.007 0.78
694_G 707_V 1.002 0.77
9_S 37_N 1.002 0.77
257_T 270_L 1.001 0.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1r6bX111000.385Contact Map0.643
1qvrA30.95781000.435Contact Map0.794
3pxiA30.91291000.468Contact Map0.75
3pxgA60.53431000.728Contact Map0.733
4hseA10.36811000.802Contact Map0.813
4fcwA30.40371000.81Contact Map0.821
3vkgA20.91821000.81Contact Map0.351
4akgA20.87731000.851Contact Map0.349
1g41A10.3761000.868Contact Map0.606
1um8A10.40111000.871Contact Map0.551

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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