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CORA - Magnesium transport protein CorA
UniProt: P0ABI4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11463
Length: 316 (313)
Sequences: 2144
Seq/Len: 6.85

CORA
Paralog alert: 0.58 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CORA ZNTB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
281_E 287_K 6.88 1.00
285_E 292_Y 3.87 1.00
97_R 100_R 3.156 1.00
296_I 300_I 2.966 1.00
28_W 103_T 2.69 1.00
30_D 105_R 2.525 1.00
283_M 292_Y 2.494 1.00
74_I 137_F 2.309 1.00
280_F 286_L 2.251 1.00
94_F 101_L 2.176 1.00
290_F 293_P 2.141 1.00
31_L 42_V 2.104 1.00
283_M 286_L 2.094 1.00
293_P 297_I 2.024 1.00
280_F 283_M 2.014 1.00
266_F 271_L 2.012 1.00
290_F 294_G 2.001 1.00
138_E 142_E 1.997 1.00
280_F 292_Y 1.979 1.00
291_G 295_A 1.959 1.00
288_W 291_G 1.939 1.00
294_G 298_F 1.933 1.00
40_L 44_S 1.904 1.00
253_N 256_I 1.859 1.00
276_Y 283_M 1.82 1.00
286_L 292_Y 1.814 1.00
272_V 295_A 1.806 1.00
282_F 289_S 1.781 1.00
271_L 275_S 1.759 1.00
96_I 133_L 1.749 1.00
275_S 296_I 1.725 1.00
285_E 293_P 1.666 1.00
280_F 285_E 1.659 1.00
288_W 294_G 1.644 1.00
276_Y 292_Y 1.64 1.00
301_L 305_A 1.626 1.00
46_L 102_F 1.604 1.00
292_Y 296_I 1.568 1.00
266_F 269_P 1.566 1.00
112_F 136_L 1.566 1.00
161_V 177_T 1.54 0.99
275_S 299_M 1.537 0.99
304_L 308_L 1.525 0.99
35_D 38_E 1.516 0.99
294_G 297_I 1.512 0.99
159_S 183_D 1.48 0.99
272_V 276_Y 1.463 0.99
289_S 293_P 1.43 0.99
116_R 120_R 1.407 0.99
215_Q 222_D 1.395 0.99
276_Y 285_E 1.383 0.99
279_N 284_P 1.382 0.99
94_F 103_T 1.379 0.98
115_Y 135_D 1.37 0.98
300_I 304_L 1.356 0.98
52_T 73_H 1.342 0.98
299_M 303_G 1.329 0.98
280_F 295_A 1.314 0.98
8_E 11_R 1.312 0.98
16_E 22_P 1.291 0.97
101_L 132_L 1.29 0.97
222_D 229_H 1.287 0.97
291_G 298_F 1.277 0.97
297_I 301_L 1.272 0.97
92_V 140_K 1.267 0.97
288_W 292_Y 1.255 0.97
222_D 226_L 1.252 0.97
257_K 261_V 1.252 0.97
3_S 14_R 1.248 0.97
229_H 233_L 1.231 0.96
128_N 131_E 1.231 0.96
283_M 293_P 1.23 0.96
276_Y 286_L 1.222 0.96
182_E 242_Q 1.219 0.96
295_A 298_F 1.219 0.96
34_P 38_E 1.219 0.96
154_D 177_T 1.212 0.96
310_F 315_W 1.209 0.96
10_N 13_T 1.205 0.96
53_R 142_E 1.191 0.95
296_I 299_M 1.182 0.95
163_M 247_F 1.181 0.95
307_Y 316_L 1.178 0.95
138_E 141_I 1.177 0.95
273_A 296_I 1.16 0.94
255_I 260_S 1.157 0.94
15_L 22_P 1.142 0.94
275_S 278_M 1.14 0.94
255_I 259_F 1.136 0.94
261_V 268_P 1.136 0.94
103_T 137_F 1.133 0.93
225_S 229_H 1.128 0.93
275_S 292_Y 1.128 0.93
264_V 269_P 1.125 0.93
224_E 227_L 1.119 0.93
222_D 225_S 1.115 0.93
219_I 222_D 1.113 0.93
9_N 13_T 1.112 0.93
268_P 271_L 1.112 0.93
295_A 299_M 1.111 0.93
211_G 219_I 1.109 0.92
305_A 309_Y 1.107 0.92
293_P 296_I 1.107 0.92
29_I 84_E 1.106 0.92
155_L 237_V 1.102 0.92
238_N 243_A 1.096 0.92
8_E 24_V 1.095 0.92
8_E 13_T 1.094 0.92
264_V 268_P 1.092 0.92
114_L 139_T 1.089 0.92
256_I 263_S 1.083 0.91
285_E 290_F 1.079 0.91
278_M 295_A 1.075 0.91
308_L 312_R 1.073 0.91
307_Y 311_K 1.071 0.91
213_L 217_R 1.062 0.90
154_D 184_I 1.061 0.90
87_A 184_I 1.053 0.90
52_T 91_T 1.051 0.90
262_V 268_P 1.05 0.89
117_M 121_S 1.048 0.89
191_C 195_T 1.048 0.89
260_S 263_S 1.042 0.89
151_I 181_L 1.04 0.89
77_F 188_V 1.039 0.89
12_L 23_L 1.038 0.89
92_V 112_F 1.037 0.89
101_L 133_L 1.036 0.89
11_R 22_P 1.028 0.88
282_F 293_P 1.025 0.88
103_T 272_V 1.021 0.88
133_L 202_L 1.02 0.88
189_R 196_Q 1.011 0.87
261_V 267_L 1.011 0.87
224_E 228_P 1.01 0.87
285_E 288_W 1.01 0.87
7_L 12_L 1.008 0.87
230_N 274_S 1.004 0.86
52_T 59_I 1.004 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ev6A50.95251000.149Contact Map0.693
4i0uA100.95571000.149Contact Map0.749
4egwA20.76581000.501Contact Map0.738
3nvoA20.74371000.531Contact Map0.622
3ck6A50.74371000.533Contact Map0.542
2bbhA10.69941000.587Contact Map0.648
2hn1A10.67721000.595Contact Map0.529
3rkgA10.702576.80.936Contact Map0.403
3t98B10.294311.80.961Contact Map0.157
3ci9A20.12979.10.963Contact Map0.999

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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