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CYOB - Ubiquinol oxidase subunit 1
UniProt: P0ABI8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10179
Length: 663 (605)
Sequences: 1949
Seq/Len: 3.22

CYOB
Paralog alert: 0.25 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
471_L 498_A 4.736 1.00
379_S 453_G 4.708 1.00
301_I 434_A 4.536 1.00
440_W 519_S 4.128 1.00
294_V 431_G 3.873 1.00
64_V 146_F 3.789 1.00
302_A 388_I 3.286 1.00
401_L 416_L 3.286 1.00
297_V 435_G 3.252 1.00
221_T 224_K 3.142 1.00
222_M 225_M 3.065 1.00
212_I 233_L 2.899 1.00
127_V 212_I 2.866 1.00
313_Y 317_V 2.847 1.00
172_A 275_Y 2.797 1.00
306_S 370_M 2.755 1.00
75_D 102_I 2.68 1.00
459_F 508_G 2.673 1.00
234_C 324_T 2.59 1.00
231_A 320_T 2.559 1.00
59_I 125_L 2.525 1.00
370_M 381_M 2.417 1.00
168_T 187_V 2.377 1.00
466_V 501_G 2.374 1.00
70_L 513_V 2.374 1.00
337_T 411_H 2.363 1.00
379_S 450_E 2.357 1.00
65_A 118_F 2.351 1.00
500_S 504_L 2.315 1.00
68_M 153_V 2.304 1.00
384_T 434_A 2.273 1.00
375_I 381_M 2.214 1.00
463_G 504_L 2.209 1.00
449_N 518_V 2.175 1.00
602_F 606_M 2.106 1.00
242_S 289_I 2.096 1.00
399_V 402_A 2.073 1.00
216_R 219_G 2.071 1.00
451_T 455_R 2.026 1.00
78_M 102_I 2.016 1.00
370_M 385_I 1.986 1.00
452_W 514_I 1.963 1.00
78_M 94_L 1.952 1.00
94_L 102_I 1.947 1.00
290_L 424_I 1.94 1.00
386_G 461_I 1.938 1.00
326_L 355_I 1.931 1.00
437_T 456_A 1.915 1.00
227_V 310_L 1.891 0.99
304_T 438_Y 1.872 0.99
297_V 301_I 1.865 0.99
194_L 250_V 1.851 0.99
108_V 172_A 1.84 0.99
158_V 189_Y 1.812 0.99
113_F 153_V 1.804 0.99
518_V 524_D 1.79 0.99
213_L 222_M 1.78 0.99
219_G 224_K 1.766 0.99
77_I 506_A 1.753 0.99
209_F 240_I 1.751 0.99
543_T 551_N 1.738 0.99
305_F 438_Y 1.731 0.99
188_D 257_R 1.728 0.99
216_R 224_K 1.727 0.99
233_L 237_V 1.722 0.99
446_F 520_I 1.69 0.99
234_C 321_V 1.681 0.98
81_S 93_F 1.658 0.98
492_H 496_M 1.647 0.98
422_N 465_F 1.645 0.98
166_A 190_W 1.628 0.98
493_T 497_I 1.625 0.98
71_R 109_I 1.625 0.98
433_F 512_L 1.623 0.98
64_V 149_T 1.62 0.98
325_V 329_I 1.61 0.98
456_A 512_L 1.609 0.98
81_S 503_V 1.607 0.98
188_D 258_Y 1.603 0.98
518_V 522_D 1.588 0.98
459_F 511_C 1.583 0.97
593_I 597_A 1.583 0.97
43_Y 47_E 1.582 0.97
159_S 190_W 1.568 0.97
283_G 286_E 1.55 0.97
64_V 150_V 1.528 0.97
213_L 237_V 1.523 0.97
298_F 384_T 1.51 0.96
452_W 511_C 1.502 0.96
77_I 81_S 1.501 0.96
282_W 286_E 1.499 0.96
295_F 359_T 1.499 0.96
450_E 454_K 1.496 0.96
442_K 545_S 1.492 0.96
466_V 497_I 1.491 0.96
213_L 233_L 1.489 0.96
205_G 236_N 1.487 0.96
79_M 99_Y 1.48 0.96
400_L 415_F 1.477 0.96
84_A 496_M 1.476 0.96
441_P 447_K 1.468 0.96
108_V 275_Y 1.449 0.95
47_E 56_R 1.441 0.95
220_M 225_M 1.435 0.95
539_L 556_P 1.434 0.95
255_L 261_T 1.43 0.95
640_V 643_I 1.425 0.95
446_F 519_S 1.422 0.94
146_F 150_V 1.416 0.94
223_F 318_W 1.415 0.94
220_M 226_P 1.407 0.94
301_I 435_G 1.404 0.94
456_A 509_I 1.393 0.94
126_V 443_A 1.392 0.94
114_V 429_V 1.391 0.94
299_S 366_W 1.389 0.94
582_E 640_V 1.37 0.93
119_V 297_V 1.369 0.93
295_F 366_W 1.362 0.93
45_W 49_L 1.361 0.93
380_A 438_Y 1.36 0.93
205_G 240_I 1.35 0.92
242_S 328_F 1.346 0.92
305_F 380_A 1.342 0.92
304_T 538_T 1.341 0.92
171_L 279_I 1.339 0.92
105_A 160_L 1.337 0.92
496_M 500_S 1.334 0.92
126_V 438_Y 1.328 0.91
127_V 229_T 1.322 0.91
209_F 233_L 1.32 0.91
543_T 552_F 1.317 0.91
217_A 220_M 1.31 0.91
462_I 504_L 1.303 0.90
549_F 638_V 1.302 0.90
431_G 434_A 1.301 0.90
433_F 456_A 1.293 0.90
452_W 455_R 1.289 0.90
503_V 507_L 1.283 0.89
455_R 511_C 1.282 0.89
628_K 631_D 1.268 0.89
373_G 533_P 1.262 0.88
426_G 464_F 1.258 0.88
59_I 443_A 1.254 0.88
108_V 190_W 1.248 0.88
594_V 624_T 1.247 0.88
307_R 376_V 1.24 0.87
79_M 107_G 1.233 0.87
406_A 410_L 1.228 0.86
440_W 520_I 1.228 0.86
469_M 473_A 1.228 0.86
94_L 98_H 1.228 0.86
172_A 187_V 1.225 0.86
97_H 101_Q 1.224 0.86
217_A 556_P 1.219 0.86
459_F 504_L 1.213 0.86
245_I 281_A 1.203 0.85
118_F 432_C 1.203 0.85
304_T 534_W 1.203 0.85
437_T 453_G 1.203 0.85
448_L 516_M 1.203 0.85
383_W 456_A 1.202 0.85
66_I 513_V 1.2 0.85
171_L 411_H 1.195 0.84
587_K 635_D 1.193 0.84
71_R 157_N 1.192 0.84
305_F 551_N 1.185 0.84
177_S 253_L 1.185 0.84
405_G 410_L 1.184 0.84
356_A 399_V 1.18 0.83
298_F 387_F 1.177 0.83
146_F 149_T 1.174 0.83
336_F 352_T 1.166 0.82
531_G 544_S 1.157 0.82
291_I 423_V 1.156 0.82
291_I 295_F 1.154 0.81
336_F 404_P 1.152 0.81
304_T 556_P 1.151 0.81
433_F 437_T 1.146 0.81
220_M 536_G 1.144 0.81
85_L 496_M 1.141 0.80
217_A 555_V 1.136 0.80
290_L 428_V 1.129 0.79
305_F 534_W 1.127 0.79
506_A 510_L 1.125 0.79
582_E 641_A 1.124 0.79
63_I 67_V 1.122 0.79
400_L 406_A 1.12 0.79
42_T 46_K 1.12 0.79
479_M 495_L 1.118 0.79
234_C 320_T 1.117 0.78
545_S 548_P 1.115 0.78
252_L 264_F 1.114 0.78
75_D 78_M 1.111 0.78
313_Y 534_W 1.109 0.78
174_P 253_L 1.106 0.77
74_A 77_I 1.105 0.77
241_A 328_F 1.104 0.77
455_R 507_L 1.102 0.77
436_M 512_L 1.096 0.77
302_A 370_M 1.094 0.76
390_T 465_F 1.094 0.76
470_P 494_M 1.09 0.76
53_D 56_R 1.088 0.76
303_A 310_L 1.084 0.75
256_D 261_T 1.083 0.75
111_I 290_L 1.082 0.75
386_G 457_F 1.081 0.75
366_W 387_F 1.079 0.75
514_I 518_V 1.076 0.75
305_F 378_H 1.076 0.75
79_M 102_I 1.075 0.75
316_L 319_A 1.074 0.75
465_F 469_M 1.073 0.74
317_V 320_T 1.072 0.74
547_P 552_F 1.07 0.74
590_G 594_V 1.069 0.74
141_L 203_L 1.065 0.74
73_F 506_A 1.065 0.74
216_R 318_W 1.064 0.74
298_F 302_A 1.062 0.73
239_I 243_F 1.061 0.73
113_F 197_S 1.06 0.73
459_F 507_L 1.06 0.73
598_F 617_G 1.06 0.73
422_N 469_M 1.059 0.73
352_T 402_A 1.058 0.73
370_M 375_I 1.058 0.73
60_M 444_F 1.057 0.73
88_A 492_H 1.054 0.73
467_A 502_A 1.053 0.72
120_I 205_G 1.05 0.72
143_N 147_W 1.045 0.72
131_I 309_R 1.042 0.71
213_L 229_T 1.042 0.71
382_L 454_K 1.04 0.71
62_I 443_A 1.04 0.71
424_I 428_V 1.037 0.71
69_L 114_V 1.036 0.71
58_G 121_G 1.036 0.71
226_P 229_T 1.033 0.70
168_T 172_A 1.032 0.70
474_L 494_M 1.03 0.70
116_M 201_T 1.029 0.70
547_P 556_P 1.026 0.70
174_P 177_S 1.026 0.70
99_Y 103_F 1.024 0.69
232_S 236_N 1.023 0.69
70_L 74_A 1.022 0.69
262_H 265_T 1.02 0.69
305_F 556_P 1.017 0.69
471_L 474_L 1.011 0.68
440_W 444_F 1.011 0.68
497_I 525_Q 1.01 0.68
446_F 523_R 1.009 0.68
237_V 321_V 1.008 0.68
379_S 454_K 1.007 0.68
306_S 375_I 1.005 0.67
451_T 454_K 1.004 0.67
301_I 384_T 1.003 0.67
574_Y 577_P 1.002 0.67
544_S 547_P 1 0.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1fftA211000.154Contact Map0.602
2yevA20.92461000.297Contact Map0.741
2gsmA20.79941000.339Contact Map0.816
1v54A20.77221000.339Contact Map0.804
3s8fA10.79791000.479Contact Map0.516
3ayfA10.77831000.492Contact Map0.468
3o0rB10.65611000.52Contact Map0.576
3mk7A40.67571000.523Contact Map0.561
1v54C20.122296.20.975Contact Map0.304
1qleC10.117696.10.975Contact Map0.515

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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