GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
CYOA - Ubiquinol oxidase subunit 2
UniProt: P0ABJ1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10178
Length: 315 (285)
Sequences: 386
Seq/Len: 1.35

CYOA
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
173_S 182_Q 4.519 1.00
155_F 222_A 3.739 1.00
45_L 49_G 3.426 1.00
129_I 153_I 3.328 1.00
133_S 185_A 2.741 1.00
227_D 230_A 2.735 1.00
145_Q 231_F 2.684 1.00
173_S 208_A 2.534 1.00
98_L 102_F 2.527 1.00
128_T 144_E 2.502 1.00
180_G 195_L 2.438 1.00
172_N 207_S 2.303 0.99
204_D 221_K 2.299 0.99
130_E 164_K 2.261 0.99
165_V 185_A 2.215 0.99
172_N 211_S 2.139 0.99
132_V 277_V 2.07 0.98
207_S 211_S 2.058 0.98
274_F 278_I 2.019 0.98
237_K 265_Y 1.961 0.97
197_A 224_A 1.934 0.97
86_N 90_A 1.915 0.97
261_N 264_E 1.895 0.96
59_I 63_V 1.845 0.95
202_T 221_K 1.842 0.95
147_I 235_V 1.788 0.94
132_V 141_I 1.778 0.94
217_G 260_Y 1.739 0.93
200_P 224_A 1.668 0.91
60_L 64_G 1.661 0.91
168_N 281_F 1.659 0.91
182_Q 209_S 1.644 0.90
35_Q 196_I 1.638 0.90
135_D 170_V 1.618 0.89
35_Q 39_E 1.578 0.88
54_V 95_V 1.56 0.87
187_A 199_E 1.54 0.86
37_G 178_R 1.531 0.86
128_T 159_T 1.53 0.86
228_R 232_D 1.518 0.85
134_M 139_F 1.514 0.85
134_M 168_N 1.486 0.83
253_K 256_A 1.466 0.82
38_L 41_R 1.458 0.82
207_S 218_M 1.45 0.81
22_L 25_C 1.432 0.80
247_D 250_A 1.428 0.80
129_I 145_Q 1.411 0.79
44_I 110_T 1.402 0.78
155_F 161_V 1.397 0.78
33_K 199_E 1.384 0.77
33_K 178_R 1.381 0.76
44_I 209_S 1.376 0.76
127_I 159_T 1.376 0.76
98_L 101_I 1.358 0.75
66_A 132_V 1.353 0.74
178_R 210_Y 1.348 0.74
110_T 113_A 1.338 0.73
108_W 112_H 1.322 0.72
157_A 200_P 1.32 0.72
158_N 198_N 1.32 0.72
73_N 185_A 1.308 0.71
31_D 210_Y 1.298 0.70
36_I 183_I 1.296 0.70
61_M 88_V 1.275 0.68
157_A 224_A 1.265 0.67
53_I 56_I 1.235 0.64
127_I 145_Q 1.231 0.64
107_T 209_S 1.229 0.64
154_A 225_T 1.229 0.64
152_E 210_Y 1.219 0.63
209_S 219_K 1.209 0.62
125_K 144_E 1.199 0.61
145_Q 149_T 1.19 0.60
162_Y 192_R 1.19 0.60
210_Y 213_P 1.188 0.60
29_L 44_I 1.176 0.59
154_A 157_A 1.166 0.58
128_T 164_K 1.165 0.58
145_Q 235_V 1.162 0.57
37_G 180_G 1.145 0.56
203_Y 224_A 1.134 0.55
286_K 290_M 1.132 0.54
286_K 289_D 1.121 0.53
28_A 178_R 1.114 0.53
53_I 95_V 1.114 0.53
95_V 262_Q 1.109 0.52
120_L 162_Y 1.108 0.52
168_N 280_K 1.098 0.51
217_G 259_E 1.097 0.51
51_M 65_F 1.093 0.51
200_P 230_A 1.09 0.50
159_T 228_R 1.088 0.50
127_I 162_Y 1.086 0.50
128_T 145_Q 1.085 0.50
164_K 190_Q 1.084 0.50
180_G 196_I 1.083 0.50
115_E 262_Q 1.081 0.49
35_Q 198_N 1.078 0.49
124_E 228_R 1.073 0.49
153_I 167_S 1.072 0.48
106_L 133_S 1.057 0.47
118_K 257_P 1.054 0.47
46_T 167_S 1.048 0.46
40_Q 181_S 1.043 0.46
155_F 197_A 1.043 0.46
153_I 222_A 1.027 0.44
33_K 44_I 1.024 0.44
159_T 164_K 1.022 0.43
197_A 222_A 1.02 0.43
125_K 263_V 1.019 0.43
40_Q 54_V 1.016 0.43
238_A 265_Y 1.012 0.42
108_W 216_S 1.01 0.42
91_V 192_R 1.009 0.42
29_L 216_S 1.009 0.42
249_A 253_K 1.007 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1fftB20.99681000.385Contact Map0.436
1cyxA10.65081000.575Contact Map0.713
2yevB20.88891000.62Contact Map0.542
3hb3B10.80631000.631Contact Map0.544
2gsmB20.71111000.644Contact Map0.582
1v54B20.65081000.675Contact Map0.59
3s8fB10.463599.90.809Contact Map0.461
3sbqA20.628699.80.845Contact Map0.438
1fwxA40.634999.80.848Contact Map0.472
2cuaA20.412799.70.859Contact Map0.694

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.6955 seconds.