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CYOC - Cytochrome o ubiquinol oxidase subunit 3
UniProt: P0ABJ3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10180
Length: 204 (182)
Sequences: 2889
Seq/Len: 15.87

CYOC
Paralog alert: 0.19 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
38_I 41_S 4.27 1.00
98_V 164_I 3.062 1.00
75_L 111_G 3.023 1.00
175_T 179_C 2.781 1.00
94_N 97_Q 2.726 1.00
103_A 161_M 2.663 1.00
82_T 105_T 2.616 1.00
95_K 99_I 2.446 1.00
82_T 104_L 2.409 1.00
85_M 101_W 2.297 1.00
142_L 198_V 2.121 1.00
95_K 167_R 2.106 1.00
74_F 78_F 2.026 1.00
177_I 181_S 1.98 1.00
46_T 138_A 1.916 1.00
110_A 114_G 1.905 1.00
39_L 145_T 1.9 1.00
113_I 151_T 1.867 1.00
99_I 165_A 1.852 1.00
158_A 162_V 1.851 1.00
50_L 134_G 1.807 1.00
68_F 118_Y 1.793 1.00
120_F 143_V 1.694 1.00
78_F 81_I 1.688 1.00
99_I 164_I 1.669 1.00
90_M 98_V 1.654 1.00
162_V 166_R 1.624 1.00
114_G 117_I 1.553 1.00
160_L 180_L 1.531 1.00
99_I 161_M 1.516 1.00
106_W 154_L 1.508 1.00
110_A 154_L 1.483 1.00
117_I 121_H 1.475 1.00
142_L 145_T 1.473 1.00
68_F 115_M 1.469 1.00
106_W 161_M 1.467 1.00
89_A 97_Q 1.462 1.00
156_W 180_L 1.462 1.00
70_L 74_F 1.453 1.00
83_Y 157_M 1.451 1.00
114_G 118_Y 1.449 1.00
110_A 151_T 1.44 1.00
48_A 197_V 1.436 1.00
106_W 158_A 1.432 1.00
118_Y 122_H 1.431 1.00
100_S 104_L 1.428 1.00
96_S 100_S 1.403 0.99
185_H 188_D 1.379 0.99
86_A 164_I 1.351 0.99
142_L 194_V 1.343 0.99
93_N 171_S 1.336 0.99
113_I 154_L 1.331 0.99
86_A 102_L 1.322 0.99
148_L 152_S 1.287 0.99
75_L 115_M 1.282 0.99
86_A 98_V 1.264 0.99
96_S 99_I 1.264 0.99
99_I 103_A 1.258 0.99
155_I 159_V 1.256 0.99
89_A 101_W 1.244 0.98
110_A 158_A 1.212 0.98
157_M 180_L 1.186 0.98
103_A 165_A 1.178 0.98
29_F 33_L 1.166 0.97
34_M 38_I 1.132 0.97
27_F 170_T 1.119 0.96
64_F 126_N 1.113 0.96
151_T 155_I 1.089 0.96
103_A 107_L 1.085 0.96
95_K 164_I 1.064 0.95
154_L 158_A 1.058 0.95
91_Y 178_M 1.051 0.94
36_D 119_E 1.05 0.94
121_H 125_V 1.049 0.94
161_M 165_A 1.042 0.94
184_W 191_W 1.042 0.94
90_M 177_I 1.04 0.94
86_A 177_I 1.029 0.94
107_L 111_G 1.026 0.94
83_Y 181_S 1.018 0.93
138_A 142_L 1.015 0.93
86_A 101_W 1.015 0.93
38_I 42_I 1.009 0.93
113_I 147_G 1.007 0.93
32_Y 183_F 1.003 0.93
89_A 94_N 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1fftC20.99511000.114Contact Map0.294
1v54C20.96571000.155Contact Map0.738
1m56C20.96081000.155Contact Map0.69
1qleC10.96081000.158Contact Map0.681
2yevA20.96081000.159Contact Map0.664
3mk7C40.31374.30.96Contact Map0.264
3rfrC30.59313.20.962Contact Map0.271
1xioA10.83332.70.963Contact Map0.269
2jafA10.92652.10.966Contact Map0.198
3ddlA20.751.50.968Contact Map0.219

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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