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COABC - Coenzyme A biosynthesis bifunctional protein CoaBC
UniProt: P0ABQ0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10004
Length: 406 (398)
Sequences: 1669
Seq/Len: 4.19

COABC
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
201_P 253_T 4.329 1.00
190_N 230_N 3.818 1.00
218_F 235_S 3.433 1.00
258_E 313_G 3.356 1.00
215_K 365_D 3.319 1.00
136_H 144_R 3.04 1.00
185_D 227_R 2.973 1.00
227_R 394_D 2.944 1.00
7_K 34_D 2.936 1.00
369_L 388_L 2.857 1.00
340_Q 344_R 2.761 1.00
224_A 393_L 2.547 1.00
333_N 336_E 2.492 1.00
11_G 107_V 2.477 1.00
13_S 94_L 2.404 1.00
227_R 393_L 2.387 1.00
44_K 62_D 2.351 1.00
288_E 332_N 2.342 1.00
25_V 56_S 2.314 1.00
80_K 160_D 2.3 1.00
197_P 237_P 2.299 1.00
96_A 134_T 2.269 1.00
281_R 305_V 2.23 1.00
283_A 303_K 2.225 1.00
351_C 369_L 2.221 1.00
3_L 33_A 2.218 1.00
98_V 120_V 2.214 1.00
10_L 25_V 2.208 1.00
193_I 220_I 2.201 1.00
190_N 232_T 2.193 1.00
255_L 259_A 2.18 1.00
36_R 58_Y 2.134 1.00
136_H 140_V 2.133 1.00
194_T 234_V 2.109 1.00
192_M 268_Q 2.102 1.00
27_R 30_D 2.051 1.00
335_E 372_F 2.032 1.00
22_P 55_V 2.012 1.00
202_L 208_I 2 1.00
194_T 261_V 2 1.00
15_G 91_T 1.995 1.00
152_D 171_T 1.975 1.00
84_L 176_A 1.965 1.00
149_W 167_L 1.959 1.00
22_P 51_S 1.955 1.00
331_T 355_V 1.934 1.00
47_I 52_L 1.931 1.00
242_T 248_R 1.931 1.00
258_E 262_N 1.913 1.00
247_K 264_S 1.891 1.00
262_N 313_G 1.866 1.00
218_F 240_L 1.858 1.00
86_I 176_A 1.855 1.00
371_L 395_E 1.834 1.00
281_R 307_N 1.821 1.00
12_V 52_L 1.814 1.00
38_A 110_I 1.805 1.00
261_V 314_V 1.804 1.00
197_P 236_G 1.801 1.00
232_T 249_V 1.797 1.00
220_I 392_L 1.797 1.00
222_A 386_E 1.785 1.00
36_R 81_W 1.774 0.99
138_L 148_I 1.772 0.99
85_V 114_T 1.761 0.99
230_N 247_K 1.734 0.99
191_I 270_I 1.728 0.99
97_R 102_M 1.723 0.99
201_P 211_H 1.718 0.99
129_Y 138_L 1.698 0.99
136_H 143_S 1.694 0.99
85_V 111_C 1.688 0.99
242_T 250_D 1.68 0.99
95_I 120_V 1.667 0.99
283_A 305_V 1.667 0.99
98_V 111_C 1.655 0.99
87_L 111_C 1.653 0.99
220_I 272_I 1.634 0.99
270_I 396_I 1.605 0.99
94_L 105_D 1.573 0.99
22_P 47_I 1.564 0.98
191_I 224_A 1.56 0.98
96_A 112_L 1.536 0.98
213_S 363_N 1.53 0.98
249_V 264_S 1.521 0.98
34_D 58_Y 1.518 0.98
39_M 43_A 1.517 0.98
223_A 390_Q 1.509 0.98
272_I 393_L 1.498 0.98
189_L 269_N 1.489 0.98
5_G 33_A 1.489 0.98
204_P 288_E 1.483 0.98
94_L 108_S 1.48 0.98
271_F 314_V 1.479 0.98
130_R 163_P 1.477 0.98
314_V 324_V 1.473 0.97
121_L 149_W 1.465 0.97
139_E 143_S 1.462 0.97
218_F 242_T 1.459 0.97
41_E 45_A 1.446 0.97
338_A 352_A 1.432 0.97
150_G 167_L 1.422 0.97
125_N 158_C 1.421 0.97
360_Q 366_N 1.414 0.97
349_L 373_W 1.411 0.96
31_R 177_V 1.41 0.96
23_E 170_L 1.404 0.96
24_L 173_V 1.4 0.96
251_V 257_M 1.391 0.96
218_F 238_V 1.381 0.96
112_L 134_T 1.375 0.96
23_E 27_R 1.372 0.96
260_A 263_A 1.363 0.95
351_C 392_L 1.361 0.95
199_R 209_S 1.359 0.95
255_L 281_R 1.358 0.95
8_I 84_L 1.348 0.95
326_G 347_L 1.342 0.95
133_A 144_R 1.342 0.95
38_A 107_V 1.336 0.95
255_L 308_P 1.334 0.95
254_A 277_V 1.329 0.95
192_M 264_S 1.327 0.95
105_D 108_S 1.309 0.94
224_A 272_I 1.308 0.94
120_V 146_L 1.297 0.94
84_L 119_A 1.29 0.93
150_G 163_P 1.29 0.93
40_T 107_V 1.286 0.93
185_D 394_D 1.279 0.93
25_V 52_L 1.275 0.93
195_A 218_F 1.268 0.93
225_A 246_V 1.258 0.92
378_K 395_E 1.254 0.92
97_R 104_N 1.25 0.92
201_P 252_M 1.249 0.92
121_L 172_I 1.24 0.91
337_Y 340_Q 1.24 0.91
6_K 83_D 1.237 0.91
234_V 261_V 1.227 0.91
202_L 282_A 1.223 0.91
140_V 144_R 1.219 0.91
273_G 311_V 1.212 0.90
119_A 179_H 1.207 0.90
349_L 371_L 1.206 0.90
192_M 234_V 1.195 0.89
255_L 307_N 1.193 0.89
199_R 252_M 1.182 0.89
93_D 104_N 1.179 0.89
98_V 146_L 1.178 0.88
41_E 63_S 1.172 0.88
148_I 167_L 1.172 0.88
366_N 382_L 1.167 0.88
39_M 44_K 1.166 0.88
24_L 86_I 1.155 0.87
226_R 390_Q 1.153 0.87
152_D 168_D 1.152 0.87
45_A 65_L 1.15 0.87
166_M 169_P 1.144 0.86
315_A 324_V 1.141 0.86
255_L 258_E 1.14 0.86
312_A 316_A 1.138 0.86
11_G 85_V 1.125 0.85
257_M 310_I 1.121 0.85
227_R 397_V 1.121 0.85
126_Q 156_Q 1.12 0.85
11_G 87_L 1.116 0.85
211_H 252_M 1.111 0.84
127_Q 160_D 1.106 0.84
334_V 352_A 1.104 0.84
152_D 167_L 1.101 0.83
129_Y 151_P 1.1 0.83
121_L 167_L 1.093 0.83
131_A 146_L 1.091 0.83
256_E 259_A 1.088 0.82
193_I 224_A 1.076 0.81
192_M 261_V 1.073 0.81
10_L 21_T 1.071 0.81
119_A 149_W 1.066 0.81
199_R 207_Y 1.065 0.81
225_A 245_F 1.064 0.80
191_I 272_I 1.063 0.80
193_I 272_I 1.061 0.80
253_T 256_E 1.058 0.80
121_L 166_M 1.056 0.80
369_L 392_L 1.054 0.80
204_P 331_T 1.054 0.80
343_I 374_Q 1.053 0.80
218_F 248_R 1.051 0.79
115_P 127_Q 1.051 0.79
111_C 118_V 1.049 0.79
92_A 112_L 1.036 0.78
260_A 264_S 1.034 0.78
202_L 302_I 1.034 0.78
270_I 400_Y 1.03 0.77
6_K 33_A 1.029 0.77
42_A 93_D 1.029 0.77
323_Y 396_I 1.022 0.77
22_P 52_L 1.021 0.77
395_E 399_R 1.019 0.76
313_G 316_A 1.019 0.76
325_V 396_I 1.015 0.76
350_I 372_F 1.013 0.76
96_A 102_M 1.012 0.76
149_W 175_M 1.008 0.75
235_S 240_L 1.007 0.75
24_L 88_A 1.002 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1p9oA20.58871000.595Contact Map0.454
1mvlA10.46551000.635Contact Map0.604
1p3y110.46061000.638Contact Map0.625
2gk4A20.50741000.639Contact Map0.647
3qjgA120.42121000.641Contact Map0.726
1u7zA30.55171000.645Contact Map0.837
1qzuA40.45571000.651Contact Map0.518
1g63A120.4361000.657Contact Map0.723
3mcuA60.47781000.664Contact Map0.553
3lqkA10.44831000.693Contact Map0.489

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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