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ERPA - Iron-sulfur cluster insertion protein ErpA
UniProt: P0ACC3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12332
Length: 114 (108)
Sequences: 2030
Seq/Len: 18.80

ERPA
Paralog alert: 0.68 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ERPA ISCA SUFA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
83_S 98_T 4.164 1.00
18_K 21_S 3.231 1.00
72_D 75_S 2.786 1.00
10_E 83_S 2.697 1.00
36_Y 48_G 2.625 1.00
61_T 68_G 2.613 1.00
102_A 105_T 2.59 1.00
63_E 68_G 2.53 1.00
13_D 65_Q 2.435 1.00
16_A 65_Q 2.351 1.00
32_K 70_V 2.155 1.00
63_E 66_G 2.119 1.00
55_V 70_V 1.951 1.00
82_G 97_V 1.924 1.00
12_T 85_D 1.904 1.00
13_D 64_K 1.871 1.00
34_R 59_D 1.871 1.00
20_K 24_A 1.758 1.00
88_E 93_S 1.668 1.00
9_L 84_V 1.634 1.00
32_K 68_G 1.583 1.00
38_T 48_G 1.531 1.00
20_K 66_G 1.383 0.99
28_N 53_D 1.353 0.99
104_S 113_S 1.31 0.99
76_L 80_V 1.235 0.98
14_A 85_D 1.22 0.98
87_T 96_I 1.178 0.98
17_N 20_K 1.165 0.97
19_V 33_L 1.163 0.97
89_G 93_S 1.148 0.97
82_G 110_S 1.143 0.97
45_F 78_Y 1.129 0.97
55_V 61_T 1.128 0.97
43_S 113_S 1.115 0.96
18_K 22_L 1.106 0.96
11_F 19_V 1.103 0.96
21_S 24_A 1.093 0.96
74_M 77_Q 1.076 0.95
77_Q 80_V 1.072 0.95
34_R 46_Q 1.063 0.95
60_M 76_L 1.055 0.95
12_T 15_A 1.053 0.95
62_I 76_L 1.045 0.94
40_G 102_A 1.044 0.94
28_N 31_L 1.013 0.93
40_G 90_L 1.01 0.93
106_C 111_S 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2d2aA20.99121000.107Contact Map0.772
1nwbA111000.116Contact Map0.607
1x0gA40.93861000.126Contact Map0.85
2apnA111000.128Contact Map0.557
1r94A20.93861000.132Contact Map0.765
2k4zA10.964999.90.297Contact Map0.711
2p2eA10.921199.80.441Contact Map0.462
2qgoA10.88699.80.452Contact Map0.499
3butA10.33337.60.933Contact Map0
4dapA10.736850.938Contact Map0.37

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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