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ASNC - Regulatory protein AsnC
UniProt: P0ACI6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10093
Length: 152 (147)
Sequences: 5726
Seq/Len: 38.95

ASNC
Paralog alert: 0.82 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: ASNC LRP YBAO
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
47_K 55_A 3.582 1.00
16_A 31_Q 2.97 1.00
97_E 110_K 2.796 1.00
62_K 117_D 2.768 1.00
53_T 60_S 2.664 1.00
104_H 137_E 2.66 1.00
16_A 23_T 2.315 1.00
114_R 118_A 2.25 1.00
25_Y 43_V 2.209 1.00
75_I 135_S 2.124 1.00
13_I 28_L 2.103 1.00
45_K 49_A 2.005 1.00
53_T 58_D 1.953 1.00
118_A 121_H 1.909 1.00
44_E 48_Q 1.885 1.00
92_L 122_V 1.871 1.00
96_T 112_M 1.84 1.00
10_D 42_R 1.837 1.00
71_F 99_Y 1.832 1.00
121_H 125_N 1.83 1.00
34_V 38_T 1.812 1.00
69_G 110_K 1.788 1.00
16_A 19_G 1.709 1.00
115_S 118_A 1.661 1.00
77_K 134_Q 1.656 1.00
26_A 30_K 1.646 1.00
85_A 89_L 1.601 1.00
23_T 28_L 1.549 1.00
23_T 31_Q 1.544 1.00
32_F 39_I 1.542 1.00
27_E 30_K 1.495 1.00
94_E 126_K 1.488 1.00
81_D 84_S 1.486 1.00
17_L 43_V 1.48 1.00
72_I 111_V 1.473 1.00
25_Y 40_H 1.44 1.00
19_G 31_Q 1.438 1.00
20_N 31_Q 1.424 1.00
9_L 34_V 1.395 0.99
83_P 87_A 1.395 0.99
7_D 42_R 1.368 0.99
120_Q 143_Q 1.367 0.99
27_E 31_Q 1.35 0.99
67_D 115_S 1.341 0.99
35_S 38_T 1.341 0.99
22_R 55_A 1.337 0.99
16_A 28_L 1.328 0.99
99_Y 144_N 1.322 0.99
88_K 91_S 1.291 0.99
73_G 139_L 1.288 0.99
26_A 36_P 1.288 0.99
94_E 118_A 1.27 0.99
74_I 109_I 1.269 0.99
66_Y 114_R 1.247 0.99
98_A 109_I 1.247 0.99
144_N 147_M 1.233 0.98
92_L 126_K 1.228 0.98
86_L 90_E 1.204 0.98
68_V 116_I 1.192 0.98
34_V 39_I 1.191 0.98
12_G 15_E 1.172 0.98
44_E 47_K 1.171 0.98
71_F 108_F 1.169 0.97
9_L 32_F 1.165 0.97
25_Y 36_P 1.152 0.97
86_L 143_Q 1.143 0.97
24_A 27_E 1.127 0.97
22_R 47_K 1.126 0.97
25_Y 29_A 1.123 0.97
8_N 12_G 1.082 0.96
23_T 27_E 1.077 0.95
36_P 40_H 1.064 0.95
84_S 88_K 1.063 0.95
73_G 105_Y 1.062 0.95
54_G 58_D 1.054 0.95
28_L 43_V 1.049 0.94
88_K 130_I 1.04 0.94
9_L 12_G 1.032 0.94
113_C 118_A 1.029 0.94
21_A 57_I 1.019 0.93
12_G 16_A 1.01 0.93
116_I 140_I 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2p5vA80.99341000.186Contact Map0.874
2e1cA10.98681000.191Contact Map0.686
2cg4A211000.195Contact Map0.6
2ia0A20.97371000.208Contact Map0.755
3i4pA10.96051000.226Contact Map0.673
2pn6A10.95391000.237Contact Map0.649
2dbbA20.97371000.249Contact Map0.78
2cyyA10.98031000.251Contact Map0.657
2gqqA411000.264Contact Map0.821
2w25A20.97371000.271Contact Map0.732

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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