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CRP - cAMP receptor protein
UniProt: P0ACJ8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10164
Length: 210 (203)
Sequences: 6173
Seq/Len: 30.41

CRP
Paralog alert: 0.75 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: CRP FNR YEIL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
39_T 97_E 3.219 1.00
25_P 28_S 2.782 1.00
23_K 94_E 2.673 1.00
45_K 94_E 2.623 1.00
51_L 88_R 2.519 1.00
145_A 191_L 2.455 1.00
105_Q 109_V 2.415 1.00
140_V 179_C 2.333 1.00
44_V 96_A 2.301 1.00
198_S 205_V 2.194 1.00
33_Q 86_W 2.185 1.00
50_V 87_V 2.129 1.00
170_R 185_G 2.127 1.00
141_T 190_M 2.12 1.00
8_T 11_T 2.107 1.00
198_S 207_Y 2.107 1.00
139_D 142_G 2.053 1.00
99_S 102_K 2.045 1.00
144_I 187_I 1.965 1.00
31_I 87_V 1.949 1.00
21_I 94_E 1.944 1.00
25_P 92_A 1.932 1.00
48_V 87_V 1.931 1.00
51_L 86_W 1.911 1.00
24_Y 30_L 1.898 1.00
32_H 35_E 1.891 1.00
89_A 93_C 1.881 1.00
22_H 97_E 1.836 1.00
24_Y 95_V 1.788 1.00
48_V 93_C 1.77 1.00
125_L 128_T 1.75 1.00
23_K 92_A 1.75 1.00
100_Y 104_R 1.748 1.00
49_A 61_I 1.748 1.00
33_Q 52_I 1.726 1.00
11_T 112_D 1.682 1.00
28_S 89_A 1.662 1.00
29_T 88_R 1.64 1.00
47_S 91_T 1.613 1.00
59_E 175_Q 1.613 1.00
49_A 88_R 1.611 1.00
29_T 32_H 1.571 1.00
11_T 110_N 1.554 1.00
140_V 183_T 1.54 1.00
179_C 184_V 1.51 1.00
152_A 206_V 1.5 1.00
14_W 109_V 1.497 1.00
108_Q 115_M 1.479 1.00
171_Q 181_R 1.473 1.00
128_T 132_V 1.465 1.00
26_S 92_A 1.463 1.00
190_M 194_Q 1.443 1.00
26_S 91_T 1.436 1.00
145_A 149_L 1.428 1.00
138_L 146_Q 1.427 1.00
141_T 194_Q 1.415 1.00
49_A 59_E 1.383 0.99
189_K 193_D 1.381 0.99
102_K 105_Q 1.379 0.99
43_I 65_L 1.372 0.99
171_Q 175_Q 1.368 0.99
134_N 146_Q 1.364 0.99
65_L 69_D 1.36 0.99
134_N 138_L 1.343 0.99
165_Q 203_T 1.341 0.99
29_T 86_W 1.338 0.99
18_H 102_K 1.336 0.99
64_Y 176_I 1.327 0.99
43_I 48_V 1.325 0.99
170_R 181_R 1.321 0.99
191_L 196_L 1.313 0.99
43_I 93_C 1.302 0.99
118_S 121_M 1.3 0.99
192_E 199_A 1.292 0.99
114_L 118_S 1.284 0.99
44_V 94_E 1.284 0.99
54_D 58_K 1.282 0.99
9_D 13_E 1.264 0.99
19_C 98_I 1.249 0.99
30_L 48_V 1.243 0.98
192_E 198_S 1.23 0.98
41_Y 97_E 1.224 0.98
30_L 41_Y 1.211 0.98
21_I 44_V 1.208 0.98
147_T 177_V 1.2 0.98
79_E 126_Q 1.2 0.98
73_E 124_R 1.198 0.98
14_W 110_N 1.18 0.98
37_A 83_R 1.164 0.97
103_F 107_I 1.158 0.97
144_I 177_V 1.107 0.96
21_I 96_A 1.101 0.96
49_A 172_E 1.1 0.96
180_S 183_T 1.09 0.96
189_K 192_E 1.088 0.96
147_T 173_I 1.086 0.96
50_V 65_L 1.085 0.96
13_E 17_S 1.077 0.95
19_C 96_A 1.074 0.95
27_K 88_R 1.072 0.95
14_W 17_S 1.068 0.95
22_H 95_V 1.065 0.95
47_S 66_N 1.046 0.94
177_V 184_V 1.043 0.94
7_Q 11_T 1.032 0.94
182_E 186_R 1.031 0.94
20_H 97_E 1.02 0.93
40_L 103_F 1.015 0.93
105_Q 108_Q 1.013 0.93
24_Y 89_A 1.012 0.93
45_K 67_Q 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rypA20.99521000.135Contact Map0.855
4hzfA20.99521000.152Contact Map0.868
3iwzA40.99521000.152Contact Map0.861
2gauA10.99521000.157Contact Map0.79
3d0sA20.99521000.161Contact Map0.803
2oz6A10.96671000.164Contact Map0.837
3e97A10.98571000.167Contact Map0.697
3dkwA100.98571000.167Contact Map0.831
3dv8A10.96671000.167Contact Map0.775
3fx3A20.97621000.171Contact Map0.772

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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