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AGAR - Putative aga operon transcriptional repressor
UniProt: P0ACK2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12762
Length: 269 (254)
Sequences: 3444
Seq/Len: 13.56

AGAR
Paralog alert: 0.83 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: AGAR DEOR FUCR GATR GLPR SGCR SRLR ULAR YCIT YDJF YGBI YIHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
121_I 220_V 3.605 1.00
108_H 182_M 3.268 1.00
99_A 102_E 3.079 1.00
183_L 214_A 2.814 1.00
113_D 207_N 2.764 1.00
151_E 158_H 2.573 1.00
25_R 40_L 2.203 1.00
182_M 218_I 2.173 1.00
123_R 143_A 2.106 1.00
211_C 235_I 2.078 1.00
111_I 180_F 1.982 1.00
218_I 242_M 1.948 1.00
233_K 236_D 1.935 1.00
242_M 265_I 1.927 1.00
100_A 220_V 1.923 1.00
182_M 216_R 1.909 1.00
25_R 29_Q 1.868 1.00
180_F 210_M 1.863 1.00
134_M 180_F 1.86 1.00
100_A 184_F 1.86 1.00
249_I 254_L 1.855 1.00
111_I 210_M 1.836 1.00
104_I 125_M 1.833 1.00
223_S 246_D 1.83 1.00
37_L 48_I 1.82 1.00
211_C 217_I 1.813 1.00
98_K 124_L 1.757 1.00
21_Q 24_Q 1.756 1.00
105_Q 108_H 1.755 1.00
112_L 118_T 1.724 1.00
236_D 239_R 1.72 1.00
133_A 150_V 1.714 1.00
216_R 242_M 1.71 1.00
106_P 129_T 1.709 1.00
121_I 184_F 1.709 1.00
94_R 120_E 1.708 1.00
254_L 258_R 1.701 1.00
97_A 124_L 1.693 1.00
155_T 171_A 1.69 1.00
108_H 181_D 1.687 1.00
106_P 128_H 1.682 1.00
101_V 124_L 1.68 1.00
173_Q 176_Q 1.661 1.00
120_E 123_R 1.636 1.00
89_N 224_S 1.635 1.00
43_V 48_I 1.628 1.00
176_Q 209_R 1.609 1.00
181_D 215_E 1.599 1.00
154_M 166_F 1.587 1.00
114_S 165_S 1.576 1.00
89_N 92_M 1.576 1.00
19_R 58_Q 1.558 1.00
141_A 154_M 1.544 1.00
52_L 68_A 1.524 1.00
23_I 26_L 1.503 1.00
196_V 219_V 1.501 1.00
23_I 60_I 1.495 1.00
99_A 265_I 1.486 1.00
21_Q 25_R 1.48 1.00
133_A 144_L 1.471 1.00
159_L 166_F 1.465 1.00
31_S 69_L 1.454 1.00
173_Q 177_N 1.45 1.00
155_T 174_S 1.444 1.00
29_Q 36_D 1.433 1.00
184_F 218_I 1.426 1.00
107_G 130_D 1.422 1.00
219_V 240_I 1.402 0.99
155_T 166_F 1.372 0.99
103_L 218_I 1.37 0.99
46_V 50_N 1.368 0.99
172_E 205_R 1.365 0.99
217_I 240_I 1.361 0.99
20_E 24_Q 1.345 0.99
226_F 243_I 1.344 0.99
209_R 213_V 1.34 0.99
101_V 121_I 1.34 0.99
103_L 244_I 1.338 0.99
25_R 32_V 1.335 0.99
97_A 101_V 1.333 0.99
176_Q 212_E 1.304 0.99
209_R 212_E 1.301 0.99
255_E 259_K 1.289 0.99
22_I 37_L 1.271 0.99
196_V 240_I 1.249 0.99
216_R 241_D 1.242 0.98
171_A 206_L 1.237 0.98
21_Q 41_Y 1.231 0.98
250_P 253_S 1.231 0.98
94_R 124_L 1.229 0.98
158_H 202_D 1.221 0.98
132_I 153_L 1.212 0.98
226_F 249_I 1.2 0.98
101_V 104_I 1.191 0.98
187_V 234_I 1.187 0.98
82_V 116_T 1.181 0.98
61_A 68_A 1.179 0.98
34_V 52_L 1.177 0.98
26_L 70_I 1.176 0.98
189_A 197_S 1.171 0.98
93_K 116_T 1.171 0.98
26_L 61_A 1.161 0.97
115_G 118_T 1.159 0.97
90_T 120_E 1.15 0.97
190_I 226_F 1.149 0.97
32_V 37_L 1.141 0.97
21_Q 40_L 1.14 0.97
92_M 246_D 1.136 0.97
25_R 28_Q 1.133 0.97
122_A 144_L 1.129 0.97
187_V 219_V 1.128 0.97
100_A 244_I 1.123 0.97
35_N 45_T 1.122 0.97
33_Q 36_D 1.119 0.96
64_A 67_G 1.113 0.96
187_V 221_T 1.112 0.96
235_I 239_R 1.106 0.96
190_I 221_T 1.094 0.96
132_I 151_E 1.075 0.95
103_L 265_I 1.074 0.95
118_T 121_I 1.073 0.95
24_Q 28_Q 1.065 0.95
100_A 121_I 1.065 0.95
92_M 223_S 1.054 0.95
122_A 143_A 1.043 0.94
117_T 222_D 1.039 0.94
208_R 212_E 1.037 0.94
218_I 244_I 1.027 0.94
93_K 225_K 1.023 0.93
79_E 85_K 1.015 0.93
106_P 130_D 1.015 0.93
160_R 203_E 1.011 0.93
104_I 184_F 1.01 0.93
15_T 54_F 1.007 0.93
175_L 209_R 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1stzA30.94051000.528Contact Map0.269
3rrlB20.63571000.54Contact Map0.581
2w48A40.8811000.597Contact Map0.582
4io1A20.60221000.621Contact Map0.7
3l7oA20.57251000.625Contact Map0.728
4gmkA20.58361000.625Contact Map0.741
1o8bA20.57991000.63Contact Map0.593
1m0sA20.57991000.635Contact Map0.717
1lk5A40.57621000.637Contact Map0.747
1uj6A10.58361000.64Contact Map0.672

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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