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ALLR - HTH-type transcriptional repressor AllR
UniProt: P0ACN4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13616
Length: 271 (250)
Sequences: 5182
Seq/Len: 20.73

ALLR
Paralog alert: 0.70 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ALLR ICLR KDGR MHPR RHMR YAGI YIAJ YJHI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
24_L 27_G 3.305 1.00
105_F 257_T 3.017 1.00
120_A 156_A 2.534 1.00
115_E 241_R 2.527 1.00
28_I 69_F 2.493 1.00
25_E 67_A 2.426 1.00
112_L 253_L 2.394 1.00
32_Q 84_G 2.364 1.00
198_Q 202_L 2.325 1.00
158_K 210_E 2.324 1.00
170_M 193_L 2.302 1.00
34_L 70_V 2.274 1.00
126_E 148_R 2.236 1.00
103_G 131_G 2.18 1.00
220_S 254_V 2.157 1.00
122_R 151_L 2.055 1.00
158_K 195_D 2.024 1.00
207_D 217_C 2.008 1.00
29_A 67_A 2 1.00
61_L 70_V 1.977 1.00
30_I 46_I 1.949 1.00
208_K 216_N 1.923 1.00
246_R 249_S 1.862 1.00
182_T 185_T 1.832 1.00
33_Y 50_L 1.787 1.00
33_Y 46_I 1.754 1.00
46_I 57_T 1.74 1.00
108_R 260_D 1.731 1.00
216_N 239_S 1.728 1.00
163_P 223_Y 1.716 1.00
110_M 117_V 1.714 1.00
108_R 112_L 1.711 1.00
32_Q 67_A 1.694 1.00
235_I 250_Q 1.68 1.00
164_L 168_E 1.677 1.00
105_F 260_D 1.671 1.00
73_D 76_L 1.655 1.00
237_G 242_L 1.649 1.00
127_A 151_L 1.613 1.00
134_E 140_R 1.603 1.00
41_S 49_N 1.595 1.00
65_Q 70_V 1.588 1.00
105_F 264_A 1.587 1.00
107_R 133_L 1.574 1.00
32_Q 69_F 1.562 1.00
42_S 45_D 1.561 1.00
251_G 255_R 1.549 1.00
34_L 41_S 1.533 1.00
220_S 258_A 1.526 1.00
209_E 239_S 1.499 1.00
106_M 117_V 1.496 1.00
102_A 261_I 1.493 1.00
169_L 193_L 1.488 1.00
71_Y 80_H 1.458 1.00
188_D 191_T 1.422 1.00
123_N 148_R 1.406 0.99
152_H 185_T 1.403 0.99
209_E 214_G 1.402 0.99
99_L 131_G 1.398 0.99
165_A 168_E 1.389 0.99
153_A 185_T 1.38 0.99
109_L 257_T 1.378 0.99
255_R 259_R 1.377 0.99
43_V 58_F 1.377 0.99
262_S 267_L 1.371 0.99
195_D 198_Q 1.351 0.99
33_Y 41_S 1.338 0.99
127_A 160_L 1.335 0.99
163_P 221_A 1.331 0.99
61_L 79_W 1.325 0.99
125_N 175_Q 1.324 0.99
166_E 197_E 1.313 0.99
223_Y 262_S 1.312 0.99
106_M 119_V 1.306 0.99
196_L 199_A 1.299 0.99
162_Y 199_A 1.297 0.99
220_S 255_R 1.291 0.99
223_Y 229_V 1.29 0.99
161_L 192_L 1.289 0.99
119_V 231_A 1.285 0.99
119_V 222_I 1.284 0.99
258_A 262_S 1.276 0.99
199_A 202_L 1.267 0.99
28_I 67_A 1.265 0.99
58_F 62_K 1.263 0.99
34_L 40_S 1.254 0.99
113_S 253_L 1.253 0.99
110_M 133_L 1.25 0.99
102_A 119_V 1.245 0.98
106_M 233_I 1.241 0.98
46_I 61_L 1.233 0.98
105_F 108_R 1.231 0.98
204_Y 251_G 1.23 0.98
47_S 57_T 1.229 0.98
122_R 125_N 1.228 0.98
256_D 260_D 1.22 0.98
189_M 193_L 1.218 0.98
154_S 157_G 1.217 0.98
220_S 251_G 1.209 0.98
22_Q 26_R 1.199 0.98
53_P 56_T 1.197 0.98
120_A 127_A 1.187 0.98
186_L 195_D 1.185 0.98
40_S 80_H 1.185 0.98
84_G 87_N 1.184 0.98
224_D 228_S 1.181 0.98
199_A 205_T 1.18 0.98
33_Y 49_N 1.179 0.98
238_P 241_R 1.174 0.98
52_L 56_T 1.166 0.97
169_L 200_R 1.161 0.97
52_L 57_T 1.157 0.97
30_I 50_L 1.141 0.97
103_G 107_R 1.134 0.97
109_L 253_L 1.132 0.97
113_S 235_I 1.127 0.97
170_M 189_M 1.111 0.96
221_A 229_V 1.11 0.96
219_A 234_S 1.109 0.96
217_C 234_S 1.094 0.96
195_D 199_A 1.088 0.96
209_E 213_V 1.076 0.95
166_E 193_L 1.075 0.95
37_S 49_N 1.073 0.95
184_T 209_E 1.072 0.95
85_V 92_Y 1.065 0.95
155_G 219_A 1.064 0.95
180_Q 187_V 1.063 0.95
112_L 256_D 1.061 0.95
233_I 261_I 1.05 0.94
44_S 48_L 1.048 0.94
113_S 250_Q 1.047 0.94
153_A 181_F 1.038 0.94
218_I 251_G 1.03 0.94
128_V 148_R 1.028 0.94
65_Q 72_Q 1.027 0.94
31_L 85_V 1.023 0.93
163_P 229_V 1.02 0.93
44_S 54_L 1.015 0.93
217_C 236_S 1.011 0.93
50_L 57_T 1.003 0.93
155_G 217_C 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ia2A40.97421000.106Contact Map0.841
2g7uA40.9411000.116Contact Map0.811
3mq0A20.98521000.116Contact Map0.749
3r4kA40.92621000.122Contact Map0.798
1mkmA20.91881000.124Contact Map0.885
2xrnA20.88931000.144Contact Map0.756
2o0yA40.94831000.172Contact Map0.782
1tf1A40.73061000.407Contact Map0.881
1ysqA10.67531000.409Contact Map0.83
1yspA10.65681000.411Contact Map0.895

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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