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CRA - Catabolite repressor/activator
UniProt: P0ACP1 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10338
Length: 334 (330)
Sequences: 13567
Seq/Len: 41.11

CRA
Paralog alert: 0.91 [within 20: 0.49] - ratio of genomes with paralogs
Cluster includes: ALSB ARAF ASCG CRA CYTR DGAL EBGR GALR GALS GNTR IDNR LACI LSRB MALI PURR RBSB RBSR TORT TRER XYLF YCJW YPHF YTFQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
179_A 240_Q 3.604 1.00
164_Q 203_T 3.597 1.00
263_K 266_S 3.432 1.00
9_L 44_E 3.389 1.00
170_L 271_A 3.055 1.00
275_D 290_A 2.753 1.00
179_A 269_A 2.659 1.00
40_A 44_E 2.64 1.00
198_E 202_R 2.509 1.00
257_T 268_L 2.495 1.00
32_D 36_E 2.446 1.00
120_A 304_V 2.44 1.00
36_E 40_A 2.42 1.00
82_Y 297_A 2.415 1.00
168_E 207_D 2.374 1.00
172_E 176_K 2.329 1.00
86_Q 302_E 2.246 1.00
157_T 307_S 2.203 1.00
299_R 302_E 2.198 1.00
167_A 171_A 2.148 1.00
168_E 203_T 2.114 1.00
86_Q 89_Q 2.109 1.00
20_V 38_V 2.099 1.00
35_V 39_M 2.093 1.00
226_A 259_R 2.071 1.00
166_D 273_F 2.022 1.00
234_E 260_R 1.97 1.00
21_I 42_V 1.925 1.00
175_R 208_D 1.915 1.00
87_A 301_L 1.884 1.00
165_D 169_M 1.878 1.00
229_F 242_L 1.86 1.00
167_A 243_F 1.85 1.00
263_K 267_D 1.834 1.00
172_E 204_A 1.834 1.00
168_E 204_A 1.831 1.00
262_G 267_D 1.796 1.00
85_R 294_R 1.786 1.00
225_A 252_G 1.775 1.00
4_D 14_R 1.767 1.00
290_A 324_N 1.762 1.00
177_F 331_L 1.755 1.00
172_E 208_D 1.755 1.00
230_E 260_R 1.739 1.00
168_E 172_E 1.735 1.00
6_I 41_V 1.719 1.00
171_A 201_F 1.705 1.00
86_Q 298_E 1.677 1.00
292_R 295_D 1.67 1.00
164_Q 199_Q 1.669 1.00
226_A 256_V 1.661 1.00
10_A 41_V 1.658 1.00
171_A 175_R 1.655 1.00
229_F 253_V 1.629 1.00
230_E 256_V 1.624 1.00
285_P 329_G 1.596 1.00
39_M 43_R 1.593 1.00
20_V 42_V 1.591 1.00
174_L 241_A 1.585 1.00
173_E 177_F 1.579 1.00
64_I 87_A 1.571 1.00
162_A 165_D 1.551 1.00
39_M 42_V 1.547 1.00
6_I 10_A 1.547 1.00
275_D 328_R 1.538 1.00
173_E 331_L 1.537 1.00
199_Q 203_T 1.531 1.00
86_Q 301_L 1.529 1.00
185_L 253_V 1.526 1.00
147_L 300_V 1.51 1.00
175_R 204_A 1.508 1.00
200_G 204_A 1.508 1.00
244_T 253_V 1.502 1.00
82_Y 294_R 1.491 1.00
258_L 283_Q 1.488 1.00
165_D 168_E 1.477 1.00
295_D 298_E 1.471 1.00
271_A 287_L 1.47 1.00
184_Y 245_T 1.457 1.00
172_E 207_D 1.456 1.00
169_M 323_R 1.452 1.00
179_A 241_A 1.444 1.00
183_L 239_P 1.444 1.00
9_L 41_V 1.44 1.00
167_A 200_G 1.437 1.00
256_V 260_R 1.407 0.99
302_E 306_A 1.405 0.99
65_G 118_V 1.4 0.99
66_L 83_L 1.399 0.99
50_N 53_A 1.398 0.99
171_A 200_G 1.395 0.99
41_V 45_H 1.395 0.99
254_M 270_I 1.394 0.99
295_D 299_R 1.394 0.99
83_L 122_I 1.378 0.99
257_T 262_G 1.378 0.99
256_V 259_R 1.377 0.99
230_E 259_R 1.371 0.99
90_R 305_L 1.367 0.99
171_A 204_A 1.363 0.99
181_T 238_M 1.347 0.99
247_F 288_A 1.324 0.99
196_L 199_Q 1.323 0.99
173_E 176_K 1.314 0.99
62_R 92_Y 1.309 0.99
31_S 34_T 1.3 0.99
3_L 17_A 1.297 0.99
175_R 210_R 1.291 0.99
87_A 94_L 1.288 0.99
86_Q 90_R 1.287 0.99
229_F 257_T 1.284 0.99
9_L 45_H 1.276 0.99
166_D 323_R 1.275 0.99
5_E 8_R 1.274 0.99
183_L 232_W 1.273 0.99
6_I 45_H 1.269 0.99
306_A 312_R 1.26 0.99
50_N 56_L 1.233 0.98
254_M 264_L 1.232 0.98
292_R 321_I 1.225 0.98
173_E 327_R 1.225 0.98
182_V 205_W 1.22 0.98
201_F 205_W 1.216 0.98
202_R 206_K 1.213 0.98
24_K 29_R 1.211 0.98
65_G 113_L 1.209 0.98
252_G 256_V 1.209 0.98
62_R 119_D 1.202 0.98
97_A 113_L 1.189 0.98
236_H 239_P 1.183 0.98
205_W 210_R 1.182 0.98
177_F 327_R 1.18 0.98
4_D 8_R 1.178 0.98
242_L 253_V 1.173 0.98
3_L 14_R 1.16 0.97
34_T 37_K 1.158 0.97
297_A 301_L 1.158 0.97
66_L 94_L 1.154 0.97
247_F 272_T 1.152 0.97
272_T 288_A 1.15 0.97
32_D 35_V 1.146 0.97
23_G 35_V 1.141 0.97
19_Y 24_K 1.14 0.97
182_V 241_A 1.136 0.97
244_T 250_L 1.136 0.97
41_V 44_E 1.135 0.97
83_L 301_L 1.128 0.97
40_A 43_R 1.128 0.97
269_A 331_L 1.128 0.97
177_F 269_A 1.123 0.97
223_E 227_Q 1.118 0.96
204_A 207_D 1.118 0.96
181_T 240_Q 1.117 0.96
37_K 41_V 1.115 0.96
53_A 56_L 1.114 0.96
97_A 109_C 1.111 0.96
227_Q 231_K 1.108 0.96
219_S 224_A 1.094 0.96
216_Y 231_K 1.092 0.96
122_I 300_V 1.089 0.96
36_E 39_M 1.086 0.96
170_L 243_F 1.082 0.96
299_R 319_T 1.08 0.95
169_M 172_E 1.07 0.95
164_Q 196_L 1.07 0.95
20_V 30_V 1.068 0.95
135_Q 139_N 1.064 0.95
176_K 208_D 1.063 0.95
170_L 289_V 1.056 0.95
247_F 250_L 1.051 0.94
164_Q 200_G 1.047 0.94
226_A 255_D 1.04 0.94
85_R 298_E 1.037 0.94
203_T 207_D 1.031 0.94
61_T 119_D 1.03 0.94
84_E 88_R 1.03 0.94
254_M 282_L 1.029 0.94
16_T 19_Y 1.028 0.94
52_V 55_G 1.024 0.93
42_V 45_H 1.019 0.93
229_F 233_L 1.016 0.93
164_Q 168_E 1.014 0.93
275_D 279_L 1.012 0.93
66_L 80_A 1.008 0.93
225_A 229_F 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dbiA30.9851000.025Contact Map0.751
2hsgA10.9791000.032Contact Map0.772
1qpzA10.9851000.033Contact Map0.778
2o20A80.97311000.036Contact Map0.855
3bilA20.9791000.044Contact Map0.674
3kjxA40.9851000.045Contact Map0.793
3e3mA40.9851000.047Contact Map0.826
3ctpA20.96711000.054Contact Map0.739
1jyeA10.9791000.056Contact Map0.774
3jvdA20.95511000.057Contact Map0.68

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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