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ACRR - HTH-type transcriptional regulator AcrR
UniProt: P0ACS9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12116
Length: 215 (200)
Sequences: 17069
Seq/Len: 85.34

ACRR
Paralog alert: 0.82 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: ACRR BDCR BETI COMR ENVR NEMR RUTR SLMA UIDR YBIH YBJK YJDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
27_Q 36_E 3.975 1.00
22_R 40_A 3.809 1.00
35_G 45_R 3.464 1.00
53_K 57_D 2.878 1.00
23_L 32_T 2.442 1.00
142_E 161_R 2.43 1.00
88_V 147_H 2.407 1.00
14_Q 65_L 2.329 1.00
26_Q 40_A 2.328 1.00
24_F 32_T 2.2 1.00
54_D 57_D 2.182 1.00
84_D 87_S 2.158 1.00
146_K 150_E 2.025 1.00
38_A 48_I 2.019 1.00
44_T 47_A 1.979 1.00
12_T 15_H 1.961 1.00
142_E 146_K 1.955 1.00
13_R 61_E 1.943 1.00
61_E 64_E 1.907 1.00
20_A 24_F 1.896 1.00
19_V 40_A 1.89 1.00
14_Q 18_D 1.879 1.00
35_G 39_K 1.84 1.00
146_K 160_T 1.836 1.00
23_L 40_A 1.813 1.00
15_H 19_V 1.79 1.00
23_L 36_E 1.781 1.00
21_L 65_L 1.688 1.00
90_R 192_R 1.672 1.00
148_C 154_L 1.671 1.00
146_K 149_I 1.666 1.00
197_I 201_M 1.647 1.00
18_D 65_L 1.633 1.00
75_L 140_R 1.62 1.00
64_E 129_A 1.61 1.00
84_D 153_M 1.578 1.00
23_L 27_Q 1.573 1.00
32_T 37_I 1.554 1.00
94_I 192_R 1.544 1.00
17_L 61_E 1.53 1.00
13_R 51_H 1.511 1.00
34_L 49_Y 1.504 1.00
34_L 48_I 1.502 1.00
57_D 61_E 1.492 1.00
24_F 29_V 1.448 1.00
28_G 31_S 1.441 1.00
162_R 193_D 1.431 1.00
28_G 32_T 1.424 1.00
19_V 22_R 1.42 1.00
148_C 153_M 1.414 1.00
85_P 151_A 1.402 0.99
56_S 123_M 1.398 0.99
52_F 61_E 1.389 0.99
34_L 45_R 1.379 0.99
169_G 173_G 1.379 0.99
22_R 26_Q 1.348 0.99
138_Y 165_I 1.347 0.99
147_H 151_A 1.336 0.99
65_L 69_N 1.327 0.99
20_A 58_L 1.324 0.99
36_E 40_A 1.306 0.99
33_S 36_E 1.301 0.99
36_E 39_K 1.294 0.99
17_L 62_I 1.293 0.99
86_L 90_R 1.28 0.99
37_I 58_L 1.279 0.99
43_V 47_A 1.256 0.99
186_D 189_K 1.245 0.98
200_E 203_L 1.22 0.98
29_V 59_F 1.218 0.98
159_M 162_R 1.215 0.98
166_I 170_Y 1.209 0.98
19_V 41_A 1.195 0.98
142_E 160_T 1.195 0.98
90_R 94_I 1.193 0.98
60_S 129_A 1.189 0.98
17_L 52_F 1.182 0.98
149_I 160_T 1.178 0.98
90_R 196_A 1.177 0.98
88_V 144_T 1.161 0.97
6_K 9_A 1.159 0.97
86_L 203_L 1.153 0.97
12_T 51_H 1.152 0.97
27_Q 31_S 1.145 0.97
11_E 15_H 1.139 0.97
18_D 22_R 1.138 0.97
196_A 200_E 1.135 0.97
145_L 160_T 1.132 0.97
138_Y 161_R 1.127 0.97
60_S 64_E 1.123 0.97
44_T 50_W 1.121 0.97
64_E 68_S 1.111 0.96
21_L 62_I 1.103 0.96
144_T 148_C 1.1 0.96
47_A 50_W 1.093 0.96
87_S 91_E 1.09 0.96
19_V 23_L 1.088 0.96
27_Q 32_T 1.077 0.95
94_I 188_K 1.046 0.94
56_S 125_V 1.041 0.94
160_T 164_A 1.038 0.94
49_Y 54_D 1.033 0.94
57_D 60_S 1.031 0.94
47_A 51_H 1.03 0.94
29_V 55_K 1.021 0.93
73_L 95_H 1.019 0.93
21_L 25_S 1.017 0.93
91_E 94_I 1.016 0.93
21_L 66_S 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xdnA40.97671000.131Contact Map0.732
3lhqA211000.182Contact Map0.748
2w53A20.99531000.182Contact Map0.797
3vibA40.97671000.184Contact Map0.752
2wuiA10.97211000.2Contact Map0.614
1vi0A20.95811000.219Contact Map0.774
2gfnA20.95351000.224Contact Map0.756
2ibdA20.93491000.23Contact Map0.745
3g1oA10.97211000.235Contact Map0.651
3knwA20.96281000.237Contact Map0.744

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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