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CUSR - Transcriptional regulatory protein CusR
UniProt: P0ACZ8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13851
Length: 227 (223)
Sequences: 27987
Seq/Len: 125.50

CUSR
Paralog alert: 0.94 [within 20: 0.55] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
13_G 29_L 3.523 1.00
13_G 31_D 2.768 1.00
17_T 29_L 2.614 1.00
34_L 56_D 2.58 1.00
6_V 36_G 2.489 1.00
32_N 56_D 2.441 1.00
172_R 192_D 2.346 1.00
57_V 65_M 2.334 1.00
154_K 157_T 2.316 1.00
28_D 45_Y 2.311 1.00
189_N 192_D 2.305 1.00
17_T 21_T 2.255 1.00
84_I 104_A 2.216 1.00
155_E 201_K 2.196 1.00
32_N 35_N 2.085 1.00
33_G 57_V 2.08 1.00
41_M 69_A 2.047 1.00
87_R 107_E 2.037 1.00
37_Y 65_M 1.964 1.00
19_G 105_F 1.951 1.00
2_K 26_V 1.942 1.00
132_D 145_S 1.913 1.00
58_N 61_D 1.906 1.00
212_Q 222_E 1.865 1.00
31_D 35_N 1.849 1.00
160_E 164_R 1.828 1.00
129_Q 134_M 1.825 1.00
141_K 148_R 1.802 1.00
30_A 39_L 1.778 1.00
2_K 28_D 1.77 1.00
47_L 112_V 1.769 1.00
77_L 90_G 1.737 1.00
212_Q 220_M 1.728 1.00
63_V 75_I 1.713 1.00
76_L 115_L 1.711 1.00
20_L 112_V 1.708 1.00
194_A 197_R 1.707 1.00
161_F 175_I 1.662 1.00
135_V 163_L 1.66 1.00
50_L 62_I 1.659 1.00
52_I 77_L 1.626 1.00
53_M 81_L 1.613 1.00
96_D 118_R 1.6 1.00
165_H 168_E 1.595 1.00
92_E 113_R 1.586 1.00
50_L 63_V 1.567 1.00
161_F 178_Q 1.563 1.00
4_L 30_A 1.539 1.00
134_M 143_T 1.537 1.00
65_M 68_S 1.53 1.00
81_L 86_H 1.503 1.00
63_V 77_L 1.487 1.00
171_P 174_L 1.463 1.00
6_V 54_L 1.46 1.00
48_I 73_M 1.445 1.00
77_L 95_A 1.428 1.00
7_E 13_G 1.4 0.99
67_R 96_D 1.4 0.99
57_V 61_D 1.394 0.99
37_Y 62_I 1.392 0.99
33_G 62_I 1.388 0.99
23_A 109_L 1.377 0.99
28_D 39_L 1.373 0.99
97_D 111_R 1.359 0.99
60_W 93_L 1.349 0.99
170_L 178_Q 1.348 0.99
61_D 64_R 1.319 0.99
195_V 199_R 1.299 0.99
65_M 69_A 1.293 0.99
34_L 57_V 1.284 0.99
39_L 42_T 1.282 0.99
38_H 42_T 1.273 0.99
136_D 139_S 1.267 0.99
52_I 60_W 1.266 0.99
39_L 43_G 1.265 0.99
166_Q 170_L 1.264 0.99
24_G 113_R 1.228 0.98
161_F 170_L 1.217 0.98
214_V 220_M 1.214 0.98
47_L 116_L 1.211 0.98
25_F 113_R 1.206 0.98
34_L 38_H 1.186 0.98
40_A 66_L 1.176 0.98
28_D 43_G 1.151 0.97
140_R 157_T 1.15 0.97
37_Y 57_V 1.145 0.97
83_T 86_H 1.142 0.97
137_L 160_E 1.133 0.97
64_R 89_K 1.132 0.97
140_R 217_V 1.124 0.97
193_V 196_K 1.111 0.96
35_N 38_H 1.111 0.96
30_A 36_G 1.11 0.96
8_D 51_D 1.107 0.96
168_E 174_L 1.101 0.96
10_K 31_D 1.101 0.96
135_V 156_F 1.1 0.96
3_L 25_F 1.099 0.96
143_T 148_R 1.098 0.96
190_A 194_A 1.096 0.96
127_Q 134_M 1.094 0.96
115_L 118_R 1.083 0.96
173_S 188_T 1.078 0.95
16_L 78_L 1.074 0.95
53_M 80_A 1.071 0.95
6_V 48_I 1.067 0.95
152_T 201_K 1.059 0.95
85_E 89_K 1.059 0.95
35_N 39_L 1.056 0.95
4_L 45_Y 1.049 0.94
84_I 88_V 1.044 0.94
5_I 27_V 1.042 0.94
4_L 36_G 1.038 0.94
36_G 40_A 1.034 0.94
60_W 89_K 1.032 0.94
161_F 165_H 1.025 0.93
114_T 119_G 1.018 0.93
88_V 106_A 1.013 0.93
138_V 168_E 1.013 0.93
4_L 39_L 1.005 0.93
70_N 73_M 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3r0jA20.98681000.124Contact Map0.689
1ys7A20.98681000.128Contact Map0.775
2gwrA10.99121000.135Contact Map0.679
1kgsA10.98241000.15Contact Map0.72
2hqrA20.96481000.161Contact Map0.677
2oqrA10.9781000.162Contact Map0.576
4b09A120.99561000.178Contact Map0.679
1p2fA10.95591000.191Contact Map0.738
3q9sA10.93391000.196Contact Map0.682
3c3wA20.94271000.255Contact Map0.631

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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