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AMPH - D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH
UniProt: P0AD70 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12867
Length: 385 (343)
Sequences: 4776
Seq/Len: 13.92

AMPH
Paralog alert: 0.63 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: AMPC AMPH YFEW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
201_K 209_E 4.373 1.00
103_Q 210_Q 3.798 1.00
220_T 256_S 3.771 1.00
109_N 133_V 3.641 1.00
208_E 213_R 3.604 1.00
110_D 114_K 3.54 1.00
96_M 206_L 3.486 1.00
58_G 345_N 3.424 1.00
107_K 110_D 3.404 1.00
99_K 206_L 3.172 1.00
81_S 233_M 3.05 1.00
99_K 210_Q 2.986 1.00
77_P 83_V 2.727 1.00
206_L 210_Q 2.725 1.00
110_D 115_Y 2.696 1.00
195_L 206_L 2.685 1.00
199_S 206_L 2.679 1.00
54_V 262_M 2.654 1.00
85_I 256_S 2.548 1.00
202_P 205_Q 2.531 1.00
217_M 220_T 2.438 1.00
69_T 75_V 2.366 1.00
95_E 264_W 2.324 1.00
65_S 79_L 2.322 1.00
63_F 66_Y 2.284 1.00
118_P 197_N 2.195 1.00
193_D 197_N 2.156 1.00
68_E 74_N 2.07 1.00
193_D 196_A 2.067 1.00
91_L 264_W 2.051 1.00
111_P 114_K 2.024 1.00
70_R 73_N 2.024 1.00
201_K 206_L 2.002 1.00
219_D 231_R 1.971 1.00
131_T 134_N 1.967 1.00
207_F 212_T 1.964 1.00
36_D 64_R 1.938 1.00
97_L 191_L 1.926 1.00
265_M 347_G 1.918 1.00
99_K 103_Q 1.888 1.00
160_T 163_Q 1.878 1.00
97_L 106_V 1.875 1.00
100_L 195_L 1.86 1.00
36_D 66_Y 1.823 1.00
212_T 217_M 1.813 1.00
265_M 338_M 1.813 1.00
192_A 250_G 1.803 1.00
209_E 213_R 1.77 1.00
50_G 83_V 1.764 1.00
201_K 210_Q 1.762 1.00
102_D 281_D 1.749 1.00
132_L 194_A 1.699 1.00
96_M 207_F 1.684 1.00
52_A 258_P 1.668 1.00
133_V 310_L 1.661 1.00
52_A 77_P 1.66 1.00
79_L 259_G 1.655 1.00
217_M 260_D 1.654 1.00
203_Y 207_F 1.652 1.00
309_G 314_Y 1.648 1.00
97_L 195_L 1.638 1.00
87_S 90_K 1.618 1.00
68_E 73_N 1.614 1.00
212_T 254_V 1.611 1.00
134_N 178_G 1.598 1.00
56_I 347_G 1.591 1.00
140_S 187_A 1.588 1.00
52_A 83_V 1.573 1.00
96_M 195_L 1.558 1.00
92_M 254_V 1.548 1.00
88_L 338_M 1.548 1.00
40_D 44_Y 1.514 1.00
94_S 136_A 1.514 1.00
235_A 334_F 1.508 1.00
56_I 262_M 1.505 1.00
94_S 188_F 1.497 1.00
80_D 259_G 1.475 1.00
54_V 349_F 1.469 1.00
281_D 284_Q 1.463 1.00
205_Q 209_E 1.458 1.00
97_L 136_A 1.458 1.00
54_V 258_P 1.453 1.00
50_G 77_P 1.451 1.00
100_L 199_S 1.449 1.00
78_Q 81_S 1.432 1.00
269_L 340_M 1.418 1.00
96_M 199_S 1.416 1.00
134_N 139_T 1.414 1.00
77_P 81_S 1.4 0.99
90_K 183_Y 1.39 0.99
86_A 331_G 1.369 0.99
266_Q 269_L 1.357 0.99
185_N 251_S 1.343 0.99
273_F 276_R 1.338 0.99
101_L 106_V 1.325 0.99
56_I 61_R 1.325 0.99
201_K 205_Q 1.321 0.99
105_T 198_A 1.315 0.99
203_Y 250_G 1.31 0.99
69_T 81_S 1.307 0.99
94_S 311_G 1.306 0.99
341_I 344_K 1.301 0.99
222_Y 254_V 1.294 0.99
273_F 278_N 1.293 0.99
92_M 264_W 1.281 0.99
110_D 132_L 1.277 0.99
217_M 264_W 1.276 0.99
53_L 350_V 1.274 0.99
282_R 286_L 1.27 0.99
194_A 198_A 1.257 0.99
261_M 349_F 1.257 0.99
101_L 108_L 1.25 0.99
106_V 198_A 1.241 0.98
339_A 348_A 1.24 0.98
107_K 115_Y 1.233 0.98
184_S 187_A 1.233 0.98
98_V 108_L 1.232 0.98
220_T 260_D 1.224 0.98
54_V 61_R 1.221 0.98
88_L 261_M 1.221 0.98
65_S 77_P 1.217 0.98
212_T 220_T 1.213 0.98
162_E 166_K 1.212 0.98
52_A 65_S 1.209 0.98
258_P 351_V 1.204 0.98
57_D 346_I 1.199 0.98
340_M 347_G 1.191 0.98
267_Q 272_D 1.19 0.98
39_A 53_L 1.189 0.98
139_T 178_G 1.183 0.98
283_M 286_L 1.18 0.98
287_I 290_R 1.176 0.98
134_N 137_T 1.171 0.98
98_V 101_L 1.168 0.97
129_P 176_A 1.163 0.97
82_V 231_R 1.162 0.97
87_S 183_Y 1.157 0.97
175_A 180_Q 1.143 0.97
92_M 217_M 1.138 0.97
261_M 351_V 1.125 0.97
100_L 103_Q 1.124 0.97
70_R 75_V 1.119 0.96
217_M 263_R 1.112 0.96
286_L 289_Q 1.105 0.96
49_T 71_P 1.097 0.96
57_D 60_Q 1.096 0.96
195_L 199_S 1.094 0.96
188_F 191_L 1.087 0.96
330_G 335_I 1.081 0.95
50_G 353_T 1.064 0.95
275_Q 279_Q 1.062 0.95
88_L 336_T 1.061 0.95
204_T 248_A 1.061 0.95
112_L 194_A 1.059 0.95
36_D 40_D 1.056 0.95
111_P 129_P 1.056 0.95
93_T 203_Y 1.055 0.95
92_M 261_M 1.053 0.95
192_A 203_Y 1.053 0.95
70_R 74_N 1.05 0.94
89_T 254_V 1.05 0.94
265_M 340_M 1.049 0.94
93_T 192_A 1.049 0.94
285_T 288_Y 1.046 0.94
215_L 267_Q 1.044 0.94
269_L 347_G 1.036 0.94
176_A 179_S 1.034 0.94
115_Y 198_A 1.031 0.94
43_F 66_Y 1.024 0.93
59_N 266_Q 1.019 0.93
276_R 279_Q 1.008 0.93
112_L 135_L 1.006 0.93
102_D 284_Q 1.005 0.93
323_G 343_Q 1.005 0.93
138_H 187_A 1.001 0.92
188_F 311_G 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rjuA10.90911000.254Contact Map0.773
2qmiA80.88831000.301Contact Map0.882
2ffyA20.84161000.302Contact Map0.818
2qz6A10.8391000.303Contact Map0.778
4ivkA10.97921000.304Contact Map0.83
2wzxA10.87011000.304Contact Map0.776
4gdnA40.86751000.306Contact Map0.881
1zkjA10.84941000.309Contact Map0.728
1ei5A10.87011000.313Contact Map0.699
4e6wA30.84161000.319Contact Map0.804

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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