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BRNQ - Branched-chain amino acid transport system 2 carrier protein
UniProt: P0AD99 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12168
Length: 439 (431)
Sequences: 810
Seq/Len: 1.88

BRNQ
Paralog alert: 0.25 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
133_V 299_T 3.621 1.00
377_I 419_M 3.091 1.00
134_I 319_F 2.872 1.00
188_N 192_N 2.613 1.00
127_L 326_M 2.49 1.00
378_S 416_T 2.454 1.00
226_R 230_W 2.444 1.00
133_V 295_A 2.399 1.00
59_T 202_A 2.36 1.00
419_M 423_A 2.236 1.00
201_G 205_F 2.072 0.99
57_V 236_G 1.985 0.99
154_L 289_I 1.938 0.98
102_T 295_A 1.826 0.97
133_V 322_G 1.794 0.97
128_V 132_I 1.775 0.97
299_T 318_V 1.764 0.97
374_P 420_V 1.735 0.96
19_A 147_V 1.734 0.96
103_A 131_A 1.728 0.96
165_A 169_W 1.725 0.96
9_D 216_R 1.715 0.96
324_F 328_V 1.707 0.96
22_V 27_I 1.677 0.95
97_F 337_I 1.665 0.95
52_A 56_P 1.648 0.95
59_T 355_V 1.645 0.95
103_A 126_S 1.641 0.94
85_L 351_C 1.618 0.94
77_I 81_A 1.597 0.93
97_F 343_V 1.595 0.93
312_L 316_T 1.594 0.93
126_S 330_N 1.589 0.93
160_V 164_V 1.583 0.93
14_G 234_M 1.565 0.92
81_A 375_M 1.556 0.92
83_V 87_T 1.536 0.91
98_A 306_F 1.535 0.91
88_V 347_I 1.528 0.91
378_S 382_G 1.5 0.90
92_A 97_F 1.494 0.90
39_E 177_A 1.465 0.89
75_T 82_G 1.459 0.88
81_A 350_P 1.456 0.88
49_L 240_T 1.44 0.88
41_V 247_F 1.437 0.87
161_I 418_V 1.426 0.87
155_K 286_L 1.418 0.86
46_F 186_F 1.416 0.86
98_A 200_L 1.413 0.86
353_A 416_T 1.394 0.85
303_A 317_L 1.389 0.85
377_I 423_A 1.384 0.85
364_W 370_V 1.379 0.84
262_N 334_S 1.375 0.84
91_L 96_L 1.365 0.84
137_S 300_C 1.363 0.83
134_I 138_L 1.356 0.83
15_F 152_A 1.347 0.82
136_V 144_L 1.342 0.82
341_V 345_T 1.338 0.82
107_F 121_P 1.337 0.82
261_A 265_A 1.334 0.82
144_L 155_K 1.311 0.80
95_P 298_L 1.304 0.79
73_L 358_S 1.293 0.79
31_P 246_L 1.291 0.79
45_A 247_F 1.281 0.78
13_L 17_T 1.276 0.77
41_V 251_S 1.266 0.77
103_A 130_F 1.264 0.76
111_I 114_L 1.263 0.76
170_P 253_S 1.256 0.76
235_A 239_L 1.249 0.75
128_V 387_I 1.248 0.75
164_V 168_V 1.245 0.75
61_V 229_V 1.245 0.75
350_P 375_M 1.243 0.75
302_C 321_L 1.242 0.75
170_P 252_D 1.239 0.74
373_P 377_I 1.238 0.74
233_L 237_V 1.238 0.74
91_L 306_F 1.233 0.74
322_G 334_S 1.233 0.74
9_D 14_G 1.221 0.73
373_P 423_A 1.219 0.73
124_I 387_I 1.218 0.73
165_A 275_F 1.212 0.72
93_V 98_A 1.21 0.72
377_I 380_L 1.202 0.71
19_A 236_G 1.197 0.71
13_L 213_A 1.191 0.70
89_C 350_P 1.19 0.70
16_M 19_A 1.189 0.70
20_L 105_V 1.187 0.70
170_P 409_G 1.184 0.70
263_G 333_L 1.184 0.70
405_L 414_M 1.181 0.69
152_A 155_K 1.178 0.69
378_S 419_M 1.174 0.69
51_T 56_P 1.171 0.68
317_L 321_L 1.169 0.68
282_L 286_L 1.168 0.68
107_F 426_W 1.167 0.68
82_G 162_L 1.165 0.68
136_V 296_V 1.164 0.68
54_G 95_P 1.162 0.67
152_A 293_V 1.161 0.67
15_F 19_A 1.159 0.67
80_V 84_L 1.157 0.67
380_L 392_F 1.146 0.66
102_T 325_S 1.14 0.65
19_A 51_T 1.138 0.65
368_S 372_A 1.138 0.65
353_A 378_S 1.137 0.65
160_V 242_L 1.132 0.65
220_E 223_L 1.131 0.64
185_A 338_Q 1.131 0.64
52_A 203_M 1.129 0.64
16_M 263_G 1.126 0.64
205_F 298_L 1.125 0.64
16_M 90_Y 1.118 0.63
323_G 418_V 1.113 0.63
90_Y 263_G 1.108 0.62
222_R 226_R 1.106 0.62
203_M 351_C 1.105 0.62
371_I 378_S 1.104 0.62
144_L 293_V 1.102 0.61
236_G 264_A 1.099 0.61
106_S 125_Y 1.098 0.61
299_T 321_L 1.098 0.61
95_P 340_S 1.098 0.61
19_A 155_K 1.095 0.61
299_T 322_G 1.094 0.61
180_A 188_N 1.094 0.61
377_I 416_T 1.093 0.61
103_A 133_V 1.093 0.61
58_L 356_V 1.09 0.60
313_S 316_T 1.088 0.60
93_V 249_L 1.087 0.60
6_R 167_I 1.087 0.60
327_V 331_L 1.086 0.60
264_A 385_D 1.085 0.60
95_P 344_L 1.084 0.60
155_K 293_V 1.084 0.60
63_L 206_G 1.084 0.60
195_L 382_G 1.083 0.59
414_M 421_V 1.083 0.59
98_A 102_T 1.081 0.59
331_L 335_Q 1.08 0.59
330_N 333_L 1.079 0.59
19_A 97_F 1.078 0.59
307_A 313_S 1.073 0.58
106_S 280_S 1.073 0.58
369_R 418_V 1.067 0.58
353_A 356_V 1.067 0.58
46_F 334_S 1.065 0.58
426_W 429_A 1.062 0.57
163_S 245_A 1.06 0.57
45_A 244_L 1.056 0.57
69_G 296_V 1.055 0.56
76_P 361_R 1.055 0.56
150_F 202_A 1.053 0.56
98_A 298_L 1.051 0.56
167_I 226_R 1.05 0.56
19_A 293_V 1.047 0.56
206_G 287_I 1.046 0.55
89_C 318_V 1.046 0.55
116_G 405_L 1.045 0.55
264_A 333_L 1.044 0.55
335_Q 338_Q 1.044 0.55
303_A 417_V 1.044 0.55
86_A 305_F 1.043 0.55
416_T 419_M 1.042 0.55
308_Q 392_F 1.041 0.55
155_K 239_L 1.039 0.55
411_A 421_V 1.038 0.55
46_F 50_I 1.031 0.54
233_L 320_I 1.031 0.54
421_V 425_I 1.028 0.54
197_M 338_Q 1.027 0.53
156_I 209_I 1.027 0.53
81_A 85_L 1.026 0.53
405_L 413_L 1.026 0.53
255_S 258_D 1.026 0.53
306_F 309_Y 1.026 0.53
376_F 379_L 1.025 0.53
123_F 127_L 1.024 0.53
126_S 329_S 1.024 0.53
377_I 405_L 1.022 0.53
50_I 186_F 1.021 0.53
162_L 286_L 1.02 0.53
53_V 240_T 1.02 0.53
292_L 296_V 1.02 0.53
232_G 371_I 1.019 0.53
70_V 204_V 1.018 0.52
14_G 45_A 1.018 0.52
131_A 134_I 1.016 0.52
132_I 292_L 1.016 0.52
353_A 406_A 1.014 0.52
70_V 86_A 1.013 0.52
200_L 306_F 1.012 0.52
151_L 294_T 1.012 0.52
19_A 195_L 1.011 0.52
134_I 322_G 1.01 0.52
284_A 303_A 1.008 0.51
213_A 224_L 1.007 0.51
104_T 122_L 1.006 0.51
43_T 46_F 1.005 0.51
239_L 293_V 1.004 0.51
280_S 284_A 1.004 0.51
303_A 318_V 1.003 0.51
70_V 149_N 1.002 0.51
89_C 200_L 1.002 0.51
58_L 61_V 1.001 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3giaA10.929499.90.827Contact Map0.29
3l1lA10.927199.80.86Contact Map0.353
4djkA20.938598.20.935Contact Map0.355
3dh4A40.922697.80.94Contact Map0.287
2xq2A10.922697.10.948Contact Map0.321
2jlnA10.911294.10.959Contact Map0.335
2a65A10.9544940.959Contact Map0.472
4m48A10.952275.20.97Contact Map0.22
4apsA20.18228.40.982Contact Map0.08
3ffvA20.13448.40.982Contact Map0

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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