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ACRA - Acriflavine resistance protein A
UniProt: P0AE06 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11703
Length: 397 (356)
Sequences: 9221
Seq/Len: 25.90

ACRA
Paralog alert: 0.80 [within 20: 0.15] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
78_K 95_Q 3.349 1.00
338_V 351_E 3.132 1.00
88_E 181_S 3.098 1.00
123_Q 127_N 3.011 1.00
92_S 175_K 3.008 1.00
335_R 357_D 2.906 1.00
327_G 333_E 2.83 1.00
109_K 168_R 2.766 1.00
258_G 278_A 2.622 1.00
130_Q 134_G 2.572 1.00
44_T 358_R 2.56 1.00
322_T 334_T 2.514 1.00
105_Y 164_V 2.456 1.00
130_Q 147_L 2.411 1.00
61_S 215_D 2.363 1.00
129_Y 138_I 2.352 1.00
47_T 355_A 2.328 1.00
116_Q 161_K 2.315 1.00
325_V 335_R 2.312 1.00
147_L 151_Q 2.255 1.00
71_Q 173_Y 2.214 1.00
98_P 102_Q 2.191 1.00
331_K 372_Q 2.166 1.00
95_Q 175_K 2.162 1.00
261_E 279_I 2.153 1.00
88_E 91_V 2.15 1.00
60_T 214_V 2.147 1.00
123_Q 154_N 2.122 1.00
129_Y 146_A 2.115 1.00
133_L 143_Y 2.102 1.00
80_N 95_Q 2.086 1.00
140_K 144_D 2.056 1.00
178_S 206_V 2.002 1.00
310_Q 347_W 1.99 1.00
243_K 257_D 1.982 1.00
307_L 346_K 1.978 1.00
326_V 373_V 1.958 1.00
92_S 177_T 1.935 1.00
45_V 356_G 1.931 1.00
340_S 350_T 1.927 1.00
47_T 304_N 1.913 1.00
80_N 92_S 1.898 1.00
126_V 143_Y 1.892 1.00
76_I 189_V 1.887 1.00
89_A 181_S 1.885 1.00
216_V 295_A 1.853 1.00
354_K 357_D 1.852 1.00
185_G 207_Q 1.834 1.00
112_L 157_V 1.834 1.00
119_A 150_A 1.827 1.00
340_S 348_L 1.815 1.00
333_E 369_P 1.799 1.00
337_I 349_V 1.794 1.00
126_V 130_Q 1.779 1.00
165_E 168_R 1.774 1.00
106_D 109_K 1.773 1.00
133_L 140_K 1.765 1.00
338_V 350_T 1.756 1.00
216_V 278_A 1.755 1.00
332_V 360_V 1.753 1.00
150_A 154_N 1.75 1.00
158_T 161_K 1.744 1.00
48_E 346_K 1.729 1.00
121_I 125_T 1.725 1.00
48_E 307_L 1.712 1.00
86_D 183_R 1.708 1.00
325_V 357_D 1.688 1.00
114_K 156_A 1.658 1.00
213_Y 277_R 1.635 1.00
102_Q 106_D 1.628 1.00
112_L 164_V 1.623 1.00
323_V 337_I 1.622 1.00
123_Q 150_A 1.595 1.00
49_P 303_P 1.592 1.00
113_A 116_Q 1.589 1.00
339_A 347_W 1.577 1.00
126_V 150_A 1.565 1.00
116_Q 120_N 1.563 1.00
161_K 165_E 1.542 1.00
45_V 306_I 1.537 1.00
76_I 94_Y 1.533 1.00
151_Q 154_N 1.528 1.00
308_V 359_V 1.521 1.00
142_E 145_Q 1.51 1.00
53_T 296_R 1.509 1.00
127_N 130_Q 1.495 1.00
184_I 204_A 1.489 1.00
74_G 96_I 1.489 1.00
82_K 85_S 1.459 1.00
42_V 326_V 1.447 1.00
119_A 123_Q 1.426 1.00
208_Q 211_P 1.424 1.00
245_S 296_R 1.419 1.00
215_D 275_T 1.414 1.00
120_N 123_Q 1.408 1.00
64_R 208_Q 1.408 1.00
306_I 355_A 1.408 1.00
302_N 348_L 1.407 0.99
102_Q 171_L 1.404 0.99
341_Q 348_L 1.402 0.99
39_A 374_K 1.401 0.99
101_Y 174_T 1.371 0.99
60_T 212_I 1.367 0.99
93_L 204_A 1.362 0.99
42_V 375_A 1.361 0.99
22_L 25_C 1.346 0.99
219_S 222_D 1.343 0.99
214_V 295_A 1.324 0.99
65_I 205_T 1.307 0.99
145_Q 149_D 1.302 0.99
42_V 358_R 1.302 0.99
55_E 294_R 1.296 0.99
120_N 151_Q 1.274 0.99
360_V 367_V 1.273 0.99
320_D 336_P 1.27 0.99
327_G 331_K 1.268 0.99
316_T 334_T 1.266 0.99
43_V 361_I 1.259 0.99
143_Y 147_L 1.257 0.99
128_R 144_D 1.237 0.98
154_N 158_T 1.234 0.98
214_V 293_V 1.23 0.98
94_Y 204_A 1.229 0.98
115_A 153_A 1.225 0.98
55_E 296_R 1.219 0.98
110_G 162_A 1.218 0.98
79_R 191_E 1.216 0.98
130_Q 143_Y 1.207 0.98
78_K 191_E 1.206 0.98
241_K 259_T 1.204 0.98
349_V 353_L 1.189 0.98
67_E 202_A 1.183 0.98
49_P 304_N 1.182 0.98
107_S 163_A 1.178 0.98
310_Q 345_D 1.172 0.98
77_L 97_D 1.172 0.98
81_F 91_V 1.166 0.97
105_Y 109_K 1.165 0.97
217_T 275_T 1.163 0.97
112_L 116_Q 1.159 0.97
282_N 285_H 1.159 0.97
178_S 181_S 1.155 0.97
126_V 147_L 1.154 0.97
44_T 356_G 1.152 0.97
262_F 277_R 1.146 0.97
308_V 323_V 1.119 0.96
259_T 279_I 1.116 0.96
305_A 348_L 1.115 0.96
122_A 153_A 1.113 0.96
166_T 170_N 1.11 0.96
267_V 274_I 1.109 0.96
131_K 135_T 1.109 0.96
125_T 145_Q 1.107 0.96
260_L 276_L 1.107 0.96
85_S 91_V 1.106 0.96
125_T 129_Y 1.101 0.96
119_A 157_V 1.101 0.96
92_S 95_Q 1.092 0.96
168_R 172_A 1.087 0.96
83_E 186_K 1.087 0.96
180_I 206_V 1.086 0.96
73_S 197_N 1.084 0.96
77_L 98_P 1.084 0.96
141_Q 145_Q 1.079 0.95
268_D 271_T 1.075 0.95
105_Y 171_L 1.074 0.95
246_L 280_F 1.07 0.95
81_F 204_A 1.061 0.95
164_V 168_R 1.059 0.95
245_S 257_D 1.059 0.95
109_K 113_A 1.059 0.95
70_P 176_V 1.059 0.95
215_D 277_R 1.052 0.95
187_S 190_T 1.05 0.94
86_D 285_H 1.048 0.94
104_T 170_N 1.047 0.94
41_G 362_S 1.043 0.94
120_N 124_L 1.042 0.94
241_K 257_D 1.042 0.94
211_P 281_P 1.041 0.94
330_D 372_Q 1.04 0.94
195_V 203_L 1.036 0.94
108_A 160_A 1.035 0.94
127_N 131_K 1.032 0.94
131_K 134_G 1.03 0.94
59_R 272_G 1.026 0.94
81_F 187_S 1.024 0.93
125_T 141_Q 1.022 0.93
119_A 154_N 1.021 0.93
71_Q 75_I 1.018 0.93
313_V 347_W 1.009 0.93
213_Y 279_I 1.005 0.93
104_T 107_S 1.005 0.93
149_D 153_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vf7A130.90681000.325Contact Map0.838
3lnnA20.8691000.361Contact Map0.741
4l8jA10.7961000.38Contact Map0.607
4dk0A10.82121000.381Contact Map0.605
3fppA20.81361000.382Contact Map0.763
3ne5B20.89421000.417Contact Map0.735
4kkuA40.72041000.423Contact Map0.78
2f1mA40.67761000.472Contact Map0.766
2k32A10.289799.90.746Contact Map0.585
2dneA10.256999.60.809Contact Map0.597

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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