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AHPC - Alkyl hydroperoxide reductase subunit C
UniProt: P0AE08 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11384
Length: 187 (180)
Sequences: 6103
Seq/Len: 33.91

AHPC
Paralog alert: 0.78 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: AHPC BCP DSBE TPX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
33_W 127_P 3.324 1.00
12_K 23_E 3.307 1.00
8_I 108_F 3.245 1.00
64_L 153_K 3.153 1.00
42_D 79_H 3.043 1.00
32_R 67_D 2.963 1.00
7_K 130_I 2.726 1.00
12_K 25_T 2.677 1.00
58_Y 62_Q 2.439 1.00
126_D 132_Q 2.365 1.00
103_A 107_N 2.202 1.00
3_L 6_T 2.184 1.00
55_A 93_K 2.122 1.00
60_E 63_K 2.007 1.00
10_P 27_K 1.977 1.00
57_H 60_E 1.946 1.00
13_N 97_I 1.917 1.00
112_R 119_D 1.905 1.00
13_N 104_L 1.891 1.00
126_D 130_I 1.857 1.00
10_P 25_T 1.839 1.00
25_T 28_D 1.796 1.00
16_F 83_H 1.79 1.00
58_Y 93_K 1.776 1.00
66_V 152_I 1.679 1.00
43_F 81_A 1.624 1.00
35_V 124_V 1.619 1.00
14_Q 23_E 1.618 1.00
15_A 20_E 1.604 1.00
59_E 63_K 1.599 1.00
70_A 96_M 1.594 1.00
73_T 105_T 1.591 1.00
62_Q 67_D 1.584 1.00
73_T 102_G 1.564 1.00
133_A 151_K 1.53 1.00
105_T 118_A 1.525 1.00
102_G 111_M 1.519 1.00
34_S 129_G 1.493 1.00
153_K 172_E 1.487 1.00
29_T 34_S 1.475 1.00
30_E 34_S 1.473 1.00
15_A 24_I 1.467 1.00
57_H 146_S 1.454 1.00
51_L 92_I 1.417 1.00
15_A 97_I 1.416 1.00
57_H 145_A 1.409 1.00
34_S 69_Y 1.392 0.99
53_D 57_H 1.391 0.99
60_E 149_L 1.382 0.99
55_A 94_Y 1.38 0.99
132_Q 138_A 1.367 0.99
80_K 84_S 1.335 0.99
59_E 62_Q 1.331 0.99
33_W 66_V 1.316 0.99
171_K 174_E 1.308 0.99
110_N 123_F 1.304 0.99
10_P 26_E 1.291 0.99
15_A 95_A 1.287 0.99
8_I 131_I 1.272 0.99
146_S 150_R 1.268 0.99
14_Q 76_H 1.255 0.99
53_D 56_D 1.254 0.99
38_F 71_V 1.242 0.98
27_K 30_E 1.237 0.98
104_L 108_F 1.23 0.98
60_E 153_K 1.224 0.98
29_T 69_Y 1.217 0.98
102_G 106_R 1.205 0.98
52_G 56_D 1.2 0.98
34_S 67_D 1.2 0.98
125_V 131_I 1.172 0.98
61_L 149_L 1.164 0.97
15_A 22_I 1.151 0.97
33_W 152_I 1.131 0.97
24_I 29_T 1.114 0.96
52_G 55_A 1.105 0.96
2_S 131_I 1.093 0.96
49_T 142_G 1.087 0.96
8_I 125_V 1.054 0.95
51_L 70_A 1.054 0.95
43_F 90_A 1.052 0.95
77_F 81_A 1.045 0.94
75_T 78_T 1.03 0.94
39_Y 42_D 1.025 0.93
123_F 131_I 1.02 0.93
58_Y 68_V 1.018 0.93
17_K 22_I 1.018 0.93
73_T 118_A 1.012 0.93
105_T 111_M 1.01 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3a2vA100.97331000.241Contact Map0.865
2v2gA40.97331000.241Contact Map0.787
3w6gA200.97331000.243Contact Map0.88
1xccA40.97331000.249Contact Map0.861
1prxA20.97331000.253Contact Map0.708
3tjjA50.97861000.268Contact Map0.846
2pn8A100.97861000.295Contact Map0.882
2c0dA20.97331000.298Contact Map0.822
1n8jA200.98931000.301Contact Map0.861
4ma9A50.98931000.307Contact Map0.847

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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