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AMPE - Protein AmpE
UniProt: P0AE14 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10042
Length: 284 (268)
Sequences: 1340
Seq/Len: 5.00

AMPE
Paralog alert: 0.20 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
154_G 158_G 4.098 1.00
168_L 196_L 3.801 1.00
91_Y 136_L 3.036 1.00
177_R 183_H 2.718 1.00
103_S 128_Y 2.563 1.00
249_H 255_T 2.4 1.00
146_A 165_Y 2.35 1.00
40_L 189_I 2.341 1.00
42_R 174_W 2.324 1.00
43_T 47_T 2.309 1.00
122_G 127_E 2.258 1.00
43_T 192_V 2.198 1.00
78_G 151_L 2.112 1.00
240_A 262_M 2.085 1.00
183_H 186_Q 2.062 1.00
143_F 172_Q 2.042 1.00
255_T 258_A 2.034 1.00
54_T 163_M 2.031 1.00
147_P 165_Y 2.02 1.00
102_D 106_R 1.981 1.00
195_V 198_W 1.976 1.00
166_A 172_Q 1.946 1.00
81_C 162_L 1.903 1.00
109_M 112_E 1.898 1.00
145_L 204_A 1.888 1.00
183_H 189_I 1.87 1.00
102_D 105_A 1.832 1.00
110_A 131_E 1.814 1.00
140_N 204_A 1.808 1.00
40_L 190_D 1.793 1.00
133_Q 259_A 1.775 1.00
85_G 89_L 1.729 1.00
31_F 46_M 1.698 1.00
78_G 162_L 1.697 1.00
141_F 146_A 1.691 0.99
115_M 237_T 1.681 0.99
165_Y 169_R 1.665 0.99
28_L 46_M 1.66 0.99
220_A 223_A 1.635 0.99
13_E 18_L 1.614 0.99
143_F 166_A 1.601 0.99
252_K 255_T 1.598 0.99
51_M 164_G 1.593 0.99
145_L 207_V 1.587 0.99
165_Y 197_D 1.547 0.99
217_A 242_F 1.531 0.99
8_L 75_L 1.512 0.99
18_L 26_H 1.502 0.99
99_S 257_K 1.496 0.98
36_K 181_P 1.493 0.98
164_G 196_L 1.482 0.98
140_N 208_Y 1.479 0.98
149_F 203_L 1.453 0.98
150_W 158_G 1.452 0.98
88_R 260_V 1.451 0.98
168_L 192_V 1.45 0.98
91_Y 132_L 1.431 0.98
110_A 128_Y 1.407 0.97
90_H 135_A 1.405 0.97
121_A 127_E 1.4 0.97
151_L 162_L 1.364 0.97
228_F 237_T 1.363 0.97
36_K 182_H 1.352 0.97
220_A 224_S 1.347 0.96
171_W 174_W 1.34 0.96
207_V 270_V 1.336 0.96
115_M 176_A 1.335 0.96
122_G 126_R 1.334 0.96
216_K 219_P 1.331 0.96
115_M 172_Q 1.311 0.96
225_L 234_Q 1.304 0.96
35_V 45_G 1.277 0.95
97_A 105_A 1.274 0.95
10_L 267_S 1.232 0.93
141_F 165_Y 1.222 0.93
99_S 254_E 1.204 0.92
208_Y 240_A 1.196 0.92
136_L 263_A 1.193 0.92
186_Q 189_I 1.183 0.91
28_L 167_F 1.173 0.91
140_N 145_L 1.172 0.91
150_W 154_G 1.169 0.91
192_V 196_L 1.167 0.91
123_C 126_R 1.162 0.91
105_A 109_M 1.161 0.90
70_T 74_W 1.159 0.90
43_T 171_W 1.147 0.90
74_W 156_T 1.139 0.89
32_F 174_W 1.139 0.89
224_S 227_D 1.134 0.89
114_T 118_G 1.133 0.89
12_F 79_L 1.129 0.89
178_Y 182_H 1.12 0.88
90_H 109_M 1.116 0.88
221_W 235_V 1.114 0.88
29_E 139_I 1.11 0.88
47_T 192_V 1.098 0.87
208_Y 239_L 1.095 0.87
94_Y 128_Y 1.094 0.87
18_L 237_T 1.09 0.86
9_V 75_L 1.089 0.86
29_E 173_Y 1.085 0.86
121_A 131_E 1.081 0.86
137_L 240_A 1.081 0.86
129_L 253_V 1.071 0.85
205_G 221_W 1.068 0.85
229_H 247_E 1.067 0.85
218_L 221_W 1.062 0.84
135_A 138_W 1.061 0.84
260_V 263_A 1.059 0.84
164_G 168_L 1.05 0.83
88_R 264_K 1.046 0.83
111_G 118_G 1.04 0.83
136_L 165_Y 1.038 0.82
57_L 73_V 1.033 0.82
166_A 169_R 1.032 0.82
244_L 259_A 1.03 0.82
26_H 30_A 1.027 0.82
47_T 164_G 1.025 0.81
223_A 227_D 1.024 0.81
14_R 84_A 1.018 0.81
108_T 112_E 1.014 0.80
221_W 225_L 1.01 0.80
46_M 50_A 1.01 0.80
225_L 235_V 1.003 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2ksdA10.33840.968Contact Map0
2l16A10.27113.60.969Contact Map0.083
4h33A10.38733.40.969Contact Map0.041
4ainA30.38732.80.971Contact Map0.225
2lzrA10.19372.30.972Contact Map0.181
4c7rA30.43661.80.973Contact Map0.226
3fwbB10.18311.40.975Contact Map0.11
2k42B10.12681.20.976Contact Map0
1afoA20.14081.10.977Contact Map0.076
4ggdC20.077510.977Contact Map0

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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