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ARAH - L-arabinose transport system permease protein AraH
UniProt: P0AE26 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10059
Length: 328 (300)
Sequences: 12824
Seq/Len: 42.75

ARAH
Paralog alert: 0.92 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: ALSC ARAH LIVH LSRC LSRD MGLC RBSC XYLH YJFF YPHD YTFT
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
110_L 230_L 4.084 1.00
114_V 226_V 3.793 1.00
207_E 221_K 3.071 1.00
117_G 229_G 2.819 1.00
216_P 219_R 2.772 1.00
114_V 230_L 2.755 1.00
91_T 112_L 2.673 1.00
113_G 229_G 2.631 1.00
200_T 224_I 2.49 1.00
118_L 226_V 2.393 1.00
113_G 233_A 2.391 1.00
62_G 180_T 2.348 1.00
69_L 279_V 2.323 1.00
203_I 220_T 2.239 1.00
101_S 104_I 2.215 1.00
126_K 218_V 2.171 1.00
219_R 223_I 2.157 1.00
110_L 234_I 2.116 1.00
190_L 196_F 2.113 1.00
95_V 108_A 2.112 1.00
189_L 193_K 2.109 1.00
120_N 138_T 2.108 1.00
186_I 190_L 2.084 1.00
196_F 223_I 2.08 1.00
257_I 290_E 2.044 1.00
64_V 258_V 2.035 1.00
118_L 222_I 1.901 1.00
38_C 292_A 1.839 1.00
196_F 200_T 1.819 1.00
58_I 287_G 1.819 1.00
215_V 220_T 1.799 1.00
188_G 192_N 1.771 1.00
199_N 220_T 1.74 1.00
202_A 210_A 1.738 1.00
86_A 146_A 1.732 1.00
265_G 278_Y 1.71 1.00
106_V 237_I 1.695 1.00
71_C 228_S 1.673 1.00
185_I 189_L 1.668 1.00
184_L 280_V 1.628 1.00
76_D 131_A 1.627 1.00
121_G 222_I 1.625 1.00
63_M 235_A 1.618 1.00
208_E 211_R 1.603 1.00
103_W 107_A 1.593 1.00
74_S 224_I 1.592 1.00
70_F 187_F 1.591 1.00
195_T 199_N 1.583 1.00
62_G 283_I 1.576 1.00
199_N 215_V 1.554 1.00
70_F 224_I 1.545 1.00
58_I 284_L 1.543 1.00
207_E 211_R 1.524 1.00
64_V 85_I 1.524 1.00
203_I 217_V 1.521 1.00
111_L 115_L 1.516 1.00
121_G 125_A 1.512 1.00
65_A 279_V 1.505 1.00
140_Q 143_R 1.495 1.00
107_A 111_L 1.49 1.00
76_D 225_F 1.488 1.00
182_A 186_I 1.471 1.00
199_N 210_A 1.461 1.00
37_A 41_F 1.455 1.00
223_I 227_L 1.453 1.00
275_K 278_Y 1.433 1.00
138_T 142_V 1.432 1.00
222_I 226_V 1.427 1.00
125_A 218_V 1.416 1.00
111_L 114_V 1.411 1.00
236_G 240_A 1.401 0.99
73_A 201_L 1.398 0.99
267_V 279_V 1.397 0.99
85_I 239_L 1.393 0.99
73_A 274_G 1.388 0.99
63_M 238_I 1.382 0.99
69_L 267_V 1.379 0.99
90_V 248_P 1.377 0.99
178_W 182_A 1.357 0.99
263_V 269_L 1.356 0.99
122_F 126_K 1.346 0.99
92_T 109_G 1.344 0.99
92_T 237_I 1.344 0.99
257_I 307_R 1.334 0.99
66_C 187_F 1.333 0.99
67_G 231_V 1.328 0.99
226_V 230_L 1.328 0.99
87_C 116_C 1.327 0.99
105_G 109_G 1.323 0.99
211_R 218_V 1.305 0.99
100_E 108_A 1.304 0.99
68_M 81_V 1.304 0.99
110_L 237_I 1.303 0.99
123_V 134_T 1.285 0.99
100_E 104_I 1.285 0.99
109_G 113_G 1.285 0.99
50_N 291_N 1.282 0.99
83_S 143_R 1.282 0.99
223_I 226_V 1.279 0.99
81_V 232_S 1.275 0.99
131_A 225_F 1.272 0.99
62_G 280_V 1.263 0.99
200_T 220_T 1.257 0.99
68_M 262_C 1.245 0.98
229_G 233_A 1.245 0.98
187_F 227_L 1.241 0.98
79_L 259_I 1.235 0.98
128_K 207_E 1.219 0.98
65_A 262_C 1.218 0.98
114_V 233_A 1.212 0.98
210_A 215_V 1.211 0.98
266_G 272_G 1.194 0.98
115_L 119_V 1.194 0.98
89_G 246_G 1.184 0.98
265_G 282_G 1.179 0.98
143_R 255_E 1.172 0.98
88_A 236_G 1.169 0.97
233_A 237_I 1.157 0.97
89_G 250_T 1.152 0.97
181_V 185_I 1.136 0.97
291_N 294_N 1.136 0.97
171_F 178_W 1.134 0.97
260_S 311_L 1.133 0.97
126_K 222_I 1.128 0.97
261_A 282_G 1.125 0.97
65_A 261_A 1.124 0.97
116_C 142_V 1.115 0.96
115_L 118_L 1.103 0.96
76_D 221_K 1.099 0.96
196_F 227_L 1.098 0.96
58_I 283_I 1.096 0.96
230_L 234_I 1.094 0.96
70_F 191_L 1.082 0.96
203_I 210_A 1.077 0.95
68_M 258_V 1.075 0.95
104_I 107_A 1.064 0.95
277_S 281_A 1.052 0.95
117_G 226_V 1.046 0.94
91_T 95_V 1.043 0.94
109_G 237_I 1.041 0.94
302_A 305_V 1.028 0.94
95_V 105_G 1.028 0.94
232_S 236_G 1.027 0.94
309_L 313_A 1.026 0.94
72_L 262_C 1.026 0.94
94_V 150_S 1.018 0.93
31_F 35_F 1.009 0.93
83_S 139_M 1.007 0.93
196_F 220_T 1.006 0.93
127_L 134_T 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2nq2A20.862890.70.918Contact Map0.534
4g1uA20.853785.10.925Contact Map0.585
2qi9A20.8628710.935Contact Map0.6
2ksfA10.3118.10.961Contact Map0.418
2kluA10.11595.50.964Contact Map0.094
3arcL20.10982.80.969Contact Map0.872
2l2tA20.1282.70.969Contact Map0.418
2ks1B10.1281.90.972Contact Map0.111
1wazA10.14021.60.973Contact Map0.153
3s8fA10.18291.60.973Contact Map0.773

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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