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ARTM - Arginine ABC transporter permease protein ArtM
UniProt: P0AE30 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11627
Length: 222 (216)
Sequences: 8047
Seq/Len: 37.25

ARTM
Paralog alert: 0.91 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
25_V 99_S 3.582 1.00
94_A 165_A 3.459 1.00
152_S 208_M 3.131 1.00
131_S 134_D 2.926 1.00
36_I 48_V 2.817 1.00
125_C 135_T 2.815 1.00
177_S 193_A 2.743 1.00
13_H 17_T 2.65 1.00
58_T 63_Q 2.608 1.00
33_F 103_A 2.498 1.00
133_K 137_A 2.391 1.00
122_W 135_T 2.377 1.00
121_Q 142_Y 2.321 1.00
43_V 47_L 2.285 1.00
33_F 107_T 2.178 1.00
43_V 46_W 2.172 1.00
19_T 159_F 2.151 1.00
34_T 110_F 2.129 1.00
113_A 147_S 2.114 1.00
52_I 107_T 2.048 1.00
37_L 49_R 1.977 1.00
206_L 210_L 1.947 1.00
116_A 146_R 1.881 1.00
198_L 202_G 1.826 1.00
122_W 126_S 1.798 1.00
9_M 13_H 1.771 1.00
175_G 179_L 1.754 1.00
21_A 95_L 1.745 1.00
19_T 162_T 1.742 1.00
29_L 103_A 1.74 1.00
106_T 151_Y 1.718 1.00
67_I 97_A 1.708 1.00
126_S 135_T 1.706 1.00
14_T 17_T 1.674 1.00
17_T 91_W 1.672 1.00
12_L 200_V 1.667 1.00
210_L 213_R 1.666 1.00
202_G 206_L 1.654 1.00
181_Y 187_V 1.611 1.00
38_T 114_I 1.577 1.00
18_L 165_A 1.553 1.00
89_E 92_L 1.545 1.00
131_S 135_T 1.532 1.00
23_L 155_V 1.527 1.00
58_T 101_N 1.514 1.00
206_L 209_R 1.491 1.00
132_K 136_L 1.486 1.00
10_K 13_H 1.48 1.00
207_M 210_L 1.476 1.00
130_M 134_D 1.476 1.00
38_T 115_R 1.452 1.00
177_S 189_V 1.437 1.00
42_P 46_W 1.435 1.00
63_Q 101_N 1.434 1.00
31_L 110_F 1.43 1.00
207_M 211_I 1.414 1.00
55_F 100_L 1.412 1.00
91_W 95_L 1.412 1.00
33_F 48_V 1.385 0.99
32_I 36_I 1.38 0.99
108_Q 111_Y 1.376 0.99
25_V 95_L 1.374 0.99
42_P 45_V 1.367 0.99
36_I 39_L 1.353 0.99
41_T 46_W 1.341 0.99
64_I 97_A 1.311 0.99
134_D 137_A 1.281 0.99
210_L 214_K 1.269 0.99
165_A 172_E 1.252 0.99
181_Y 190_F 1.221 0.98
47_L 50_G 1.204 0.98
106_T 154_E 1.201 0.98
26_A 102_S 1.199 0.98
110_F 147_S 1.183 0.98
17_T 21_A 1.182 0.98
37_L 108_Q 1.178 0.98
21_A 99_S 1.174 0.98
126_S 132_K 1.171 0.98
163_S 197_Y 1.171 0.98
30_A 106_T 1.163 0.97
14_T 170_L 1.159 0.97
36_I 44_L 1.159 0.97
28_I 32_I 1.151 0.97
171_M 175_G 1.137 0.97
117_I 146_R 1.135 0.97
46_W 50_G 1.129 0.97
24_I 28_I 1.125 0.97
157_L 161_S 1.097 0.96
45_V 49_R 1.091 0.96
111_Y 115_R 1.09 0.96
53_T 202_G 1.088 0.96
159_F 204_L 1.087 0.96
125_C 138_I 1.08 0.95
159_F 200_V 1.06 0.95
122_W 139_L 1.059 0.95
176_Y 179_L 1.059 0.95
109_L 154_E 1.051 0.94
203_L 207_M 1.038 0.94
92_L 96_I 1.032 0.94
22_S 99_S 1.027 0.94
175_G 178_Q 1.022 0.93
65_F 69_Y 1.021 0.93
55_F 104_A 1.01 0.93
136_L 140_L 1.01 0.93
195_I 199_V 1.008 0.93
50_G 54_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.936999.90.603Contact Map0.779
2onkC40.986599.90.625Contact Map0.587
3d31C20.986599.90.631Contact Map0.546
3rlfF10.977599.80.634Contact Map0.628
3rlfG10.968599.80.667Contact Map0.489
3e7lA40.27932.80.965Contact Map0.583
2pqrC20.09912.10.967Contact Map0.642
3zjzA40.34231.80.969Contact Map0.322
4l5eA10.20271.70.969Contact Map0.533
4humA10.39641.60.969Contact Map0.167

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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