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COBU - Bifunctional adenosylcobalamin biosynthesis protein CobU
UniProt: P0AE76 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13238
Length: 181 (180)
Sequences: 1098
Seq/Len: 6.10

COBU
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
145_S 148_A 4.161 1.00
6_T 134_T 3.297 1.00
18_E 50_G 3.019 1.00
82_C 135_N 2.869 1.00
27_V 52_P 2.775 1.00
35_I 44_I 2.765 1.00
83_V 162_L 2.743 1.00
18_E 29_Y 2.576 1.00
6_T 174_S 2.501 1.00
10_R 43_R 2.348 1.00
21_I 131_V 2.33 1.00
43_R 153_D 2.309 1.00
63_H 66_E 2.183 1.00
64_L 80_L 2.171 1.00
2_M 166_A 2.156 1.00
4_L 169_V 2.132 1.00
17_A 133_V 2.131 1.00
42_A 45_E 2.124 1.00
46_H 50_G 2.12 1.00
21_I 77_V 2.07 1.00
168_E 179_K 2.043 1.00
29_Y 50_G 1.985 1.00
9_A 152_R 1.955 1.00
28_L 58_V 1.842 1.00
123_C 130_V 1.771 1.00
38_D 41_A 1.719 1.00
88_T 92_F 1.712 1.00
80_L 132_L 1.712 1.00
139_M 171_L 1.711 1.00
141_I 148_A 1.659 1.00
16_H 170_W 1.638 1.00
171_L 178_V 1.624 1.00
45_E 49_Q 1.615 1.00
4_L 134_T 1.606 0.99
134_T 159_N 1.484 0.99
30_I 80_L 1.483 0.99
176_I 180_I 1.469 0.99
87_V 158_V 1.453 0.99
173_V 180_I 1.441 0.99
144_E 148_A 1.414 0.98
170_W 179_K 1.399 0.98
84_T 155_A 1.396 0.98
29_Y 79_L 1.393 0.98
5_V 16_H 1.377 0.98
115_E 118_S 1.375 0.98
3_I 170_W 1.358 0.98
151_F 155_A 1.356 0.98
50_G 79_L 1.333 0.97
16_H 20_L 1.33 0.97
143_P 152_R 1.318 0.97
5_V 131_V 1.308 0.97
117_Q 161_Q 1.265 0.96
10_R 153_D 1.241 0.96
69_H 118_S 1.238 0.96
145_S 152_R 1.229 0.95
154_I 158_V 1.219 0.95
80_L 86_M 1.212 0.95
153_D 160_Q 1.209 0.95
15_R 160_Q 1.208 0.95
123_C 166_A 1.194 0.94
141_I 152_R 1.188 0.94
61_W 89_N 1.184 0.94
2_M 132_L 1.16 0.93
144_E 152_R 1.144 0.92
123_C 132_L 1.141 0.92
92_F 147_L 1.139 0.92
16_H 172_V 1.139 0.92
137_V 141_I 1.135 0.92
84_T 135_N 1.119 0.91
173_V 178_V 1.108 0.91
21_I 27_V 1.099 0.90
139_M 173_V 1.094 0.90
6_T 139_M 1.08 0.89
177_G 181_K 1.079 0.89
169_V 180_I 1.066 0.88
15_R 19_A 1.063 0.88
26_Q 76_E 1.061 0.88
146_R 150_H 1.06 0.88
159_N 163_A 1.045 0.87
126_C 130_V 1.045 0.87
141_I 145_S 1.043 0.87
3_I 20_L 1.04 0.87
176_I 181_K 1.038 0.87
30_I 67_L 1.036 0.87
39_E 149_R 1.035 0.86
88_T 151_F 1.032 0.86
163_A 169_V 1.032 0.86
33_S 40_M 1.031 0.86
123_C 162_L 1.031 0.86
18_E 22_G 1.005 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1c9kA30.99451000.114Contact Map0.731
3cmuA10.911699.40.77Contact Map0.338
3cmwA20.939298.60.833Contact Map0.505
3io5A20.961398.50.839Contact Map0.384
2zr9A10.9337980.86Contact Map0.513
3hr8A10.922797.90.861Contact Map0.471
3ldaA10.889597.90.862Contact Map0.481
1u94A10.933797.90.862Contact Map0.545
1xp8A10.933797.80.866Contact Map0.605
1g5tA10.773597.60.871Contact Map0.311

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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