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CORC - Magnesium and cobalt efflux protein CorC
UniProt: P0AE78 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13654
Length: 292 (253)
Sequences: 3583
Seq/Len: 14.16

CORC
Paralog alert: 0.73 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: CORC YFJD YTFL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
249_H 255_E 4.078 1.00
79_M 178_L 3.8 1.00
214_V 279_V 3.342 1.00
258_D 263_Q 2.929 1.00
256_T 265_K 2.904 1.00
213_T 267_A 2.896 1.00
81_T 106_I 2.714 1.00
107_S 112_H 2.632 1.00
256_T 263_Q 2.539 1.00
167_I 178_L 2.518 1.00
87_T 90_E 2.516 1.00
105_V 139_L 2.49 1.00
243_V 277_V 2.451 1.00
145_V 154_M 2.406 1.00
208_S 211_T 2.343 1.00
107_S 136_D 2.293 1.00
149_K 157_E 2.241 1.00
121_D 140_R 2.223 1.00
57_M 61_V 2.184 1.00
223_F 227_F 2.144 1.00
86_Q 90_E 2.064 1.00
263_Q 280_K 2.055 1.00
167_I 175_V 1.987 1.00
79_M 175_V 1.944 1.00
111_D 174_G 1.923 1.00
213_T 276_Q 1.912 1.00
134_S 137_K 1.889 1.00
72_I 151_V 1.839 1.00
81_T 110_K 1.821 1.00
82_L 91_C 1.816 1.00
84_R 107_S 1.815 1.00
207_L 211_T 1.794 1.00
265_K 280_K 1.792 1.00
268_M 275_I 1.757 1.00
67_Q 71_D 1.757 1.00
206_Q 212_W 1.74 1.00
101_S 118_M 1.725 1.00
84_R 136_D 1.72 1.00
41_I 58_L 1.712 1.00
85_N 107_S 1.711 1.00
211_T 278_H 1.677 1.00
218_A 239_I 1.675 1.00
57_M 188_I 1.668 1.00
83_K 86_Q 1.657 1.00
265_K 278_H 1.65 1.00
194_D 197_D 1.638 1.00
185_L 189_V 1.633 1.00
218_A 223_F 1.625 1.00
95_I 103_F 1.617 1.00
69_V 154_M 1.617 1.00
86_Q 91_C 1.615 1.00
242_L 259_I 1.609 1.00
93_D 97_E 1.577 1.00
268_M 276_Q 1.576 1.00
182_E 186_E 1.563 1.00
116_I 142_A 1.556 1.00
84_R 114_E 1.549 1.00
224_N 229_T 1.534 1.00
239_I 277_V 1.53 1.00
223_F 279_V 1.515 1.00
207_L 213_T 1.497 1.00
107_S 114_E 1.447 1.00
156_K 159_R 1.443 1.00
213_T 278_H 1.437 1.00
98_S 103_F 1.434 1.00
102_R 164_H 1.427 1.00
204_F 218_A 1.419 1.00
82_L 105_V 1.416 1.00
44_S 48_D 1.408 1.00
267_A 278_H 1.388 0.99
154_M 179_V 1.383 0.99
151_V 184_I 1.383 0.99
270_D 275_I 1.381 0.99
147_E 176_S 1.369 0.99
109_D 112_H 1.366 0.99
244_M 274_I 1.355 0.99
223_F 239_I 1.332 0.99
246_A 259_I 1.323 0.99
264_F 279_V 1.298 0.99
37_L 44_S 1.29 0.99
108_E 112_H 1.269 0.99
113_I 167_I 1.262 0.99
220_I 236_V 1.252 0.99
76_R 174_G 1.246 0.98
64_I 184_I 1.232 0.98
214_V 223_F 1.226 0.98
33_N 36_E 1.223 0.98
264_F 277_V 1.19 0.98
207_L 210_H 1.189 0.98
236_V 245_Q 1.183 0.98
224_N 231_F 1.178 0.98
243_V 257_I 1.177 0.98
61_V 188_I 1.164 0.97
182_E 192_I 1.157 0.97
102_R 182_E 1.155 0.97
220_I 224_N 1.148 0.97
204_F 214_V 1.146 0.97
214_V 239_I 1.144 0.97
206_Q 209_R 1.143 0.97
267_A 276_Q 1.14 0.97
262_Y 279_V 1.136 0.97
204_F 226_A 1.131 0.97
262_Y 281_I 1.122 0.97
116_I 165_M 1.106 0.96
78_Q 217_L 1.106 0.96
72_I 179_V 1.105 0.96
243_V 266_V 1.094 0.96
149_K 154_M 1.093 0.96
205_R 213_T 1.089 0.96
34_R 66_D 1.088 0.96
263_Q 282_P 1.087 0.96
33_N 37_L 1.083 0.96
261_G 281_I 1.072 0.95
165_M 178_L 1.071 0.95
79_M 110_K 1.069 0.95
45_G 55_R 1.068 0.95
165_M 180_T 1.058 0.95
77_S 174_G 1.048 0.94
207_L 278_H 1.048 0.94
86_Q 94_V 1.046 0.94
80_I 103_F 1.046 0.94
182_E 194_D 1.044 0.94
114_E 139_L 1.033 0.94
80_I 100_H 1.022 0.93
78_Q 273_R 1.021 0.93
211_T 280_K 1.015 0.93
244_M 250_L 1.011 0.93
182_E 197_D 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hg0A111000.249Contact Map0.738
3lhhA10.58221000.683Contact Map0.821
3ocoA20.520599.90.701Contact Map0.837
3oi8A20.534299.90.703Contact Map0.845
3ocmA20.592599.90.712Contact Map0.858
2v8qE10.873399.90.716Contact Map0.524
3lv9A10.506899.90.721Contact Map0.81
3kxrA10.667899.90.723Contact Map0.61
3dedA60.369999.90.736Contact Map0.79
2qrdG20.818599.90.744Contact Map0.54

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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