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CPXA - Sensor protein CpxA
UniProt: P0AE82 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10163
Length: 457 (453)
Sequences: 2998
Seq/Len: 6.62

CPXA
Paralog alert: 0.73 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: ATOS BAES BASS CPXA CREC CUSS DCUS DPIB ENVZ GLRK NTRB PHOQ PHOR QSEC RSTB YEDV ZRAS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
386_D 390_G 4.834 1.00
437_A 447_L 4.15 1.00
385_D 446_R 4.133 1.00
424_V 435_V 4.128 1.00
89_T 93_R 4.099 1.00
425_E 429_Q 4.016 1.00
365_S 387_D 3.408 1.00
400_F 435_V 3.37 1.00
433_G 451_L 3.178 1.00
428_I 433_G 3.16 1.00
439_D 445_L 3.138 1.00
258_Q 282_Q 3.085 1.00
353_A 427_A 3.063 1.00
428_I 449_I 2.971 1.00
345_G 350_L 2.758 1.00
345_G 431_H 2.723 1.00
379_G 450_W 2.576 1.00
208_H 233_E 2.521 1.00
372_G 385_D 2.496 1.00
199_E 204_N 2.458 1.00
216_Q 219_L 2.449 1.00
241_R 245_D 2.42 1.00
391_V 399_I 2.419 1.00
306_E 347_P 2.415 1.00
396_R 439_D 2.411 1.00
386_D 444_G 2.4 1.00
440_S 443_G 2.385 1.00
427_A 431_H 2.326 1.00
353_A 428_I 2.326 1.00
398_Q 401_R 2.309 1.00
438_E 446_R 2.272 1.00
399_I 437_A 2.234 1.00
400_F 447_L 2.186 1.00
412_R 415_G 2.139 1.00
364_Y 405_R 2.121 1.00
407_D 410_R 2.119 1.00
383_T 446_R 2.07 1.00
214_G 219_L 2.049 1.00
357_I 447_L 2.044 1.00
343_L 451_L 1.988 1.00
434_W 450_W 1.987 1.00
308_I 345_G 1.959 1.00
433_G 452_P 1.949 1.00
353_A 449_I 1.948 1.00
376_D 381_T 1.943 1.00
437_A 445_L 1.923 1.00
359_R 363_R 1.92 1.00
225_F 228_M 1.914 1.00
325_A 362_L 1.89 1.00
428_I 451_L 1.884 1.00
200_V 229_V 1.812 1.00
419_L 423_I 1.811 1.00
309_K 312_Q 1.801 1.00
333_T 370_E 1.772 1.00
307_T 342_P 1.751 1.00
307_T 344_Y 1.742 1.00
439_D 442_L 1.735 1.00
392_S 406_T 1.729 1.00
400_F 437_A 1.71 1.00
395_D 404_Y 1.703 1.00
335_N 372_G 1.691 1.00
372_G 383_T 1.686 1.00
436_K 448_V 1.685 1.00
317_V 358_V 1.684 1.00
316_E 347_P 1.681 1.00
258_Q 285_D 1.676 1.00
375_V 453_L 1.637 1.00
374_A 383_T 1.615 1.00
208_H 229_V 1.607 1.00
242_L 246_I 1.602 1.00
309_K 339_G 1.6 1.00
349_A 352_S 1.596 1.00
208_H 230_T 1.583 1.00
357_I 424_V 1.578 1.00
383_T 448_V 1.572 1.00
280_E 283_R 1.565 0.99
381_T 450_W 1.551 0.99
391_V 445_L 1.538 0.99
197_A 225_F 1.536 0.99
438_E 448_V 1.524 0.99
380_I 453_L 1.522 0.99
277_I 281_A 1.52 0.99
428_I 435_V 1.513 0.99
308_I 350_L 1.501 0.99
386_D 445_L 1.501 0.99
200_V 228_M 1.486 0.99
179_L 183_A 1.483 0.99
354_L 382_I 1.471 0.99
386_D 441_P 1.43 0.99
439_D 443_G 1.424 0.99
392_S 395_D 1.421 0.99
381_T 448_V 1.414 0.99
330_K 365_S 1.412 0.99
208_H 226_N 1.397 0.99
286_S 348_N 1.392 0.99
349_A 430_Q 1.39 0.98
400_F 425_E 1.385 0.98
395_D 406_T 1.376 0.98
370_E 385_D 1.363 0.98
303_L 346_N 1.361 0.98
318_L 371_V 1.358 0.98
399_I 447_L 1.352 0.98
386_D 389_P 1.349 0.98
206_R 233_E 1.339 0.98
314_W 354_L 1.338 0.98
429_Q 434_W 1.331 0.98
242_L 292_L 1.328 0.98
245_D 402_P 1.325 0.98
335_N 374_A 1.319 0.98
316_E 351_E 1.312 0.98
236_M 239_Q 1.294 0.97
435_V 447_L 1.292 0.97
205_L 232_L 1.29 0.97
405_R 416_G 1.289 0.97
310_A 380_I 1.288 0.97
305_S 344_Y 1.284 0.97
325_A 369_I 1.272 0.97
245_D 410_R 1.264 0.97
190_A 218_F 1.259 0.97
442_L 445_L 1.255 0.97
390_G 444_G 1.232 0.96
396_R 437_A 1.231 0.96
215_P 219_L 1.224 0.96
401_R 425_E 1.221 0.96
285_D 289_N 1.219 0.96
350_L 451_L 1.211 0.96
364_Y 389_P 1.206 0.95
202_Q 231_A 1.198 0.95
349_A 427_A 1.197 0.95
290_D 349_A 1.19 0.95
257_L 281_A 1.188 0.95
370_E 387_D 1.182 0.95
4_S 8_R 1.18 0.95
391_V 439_D 1.178 0.95
439_D 446_R 1.171 0.94
340_P 373_F 1.166 0.94
390_G 445_L 1.165 0.94
242_L 249_E 1.163 0.94
346_N 349_A 1.163 0.94
343_L 380_I 1.162 0.94
203_G 229_V 1.161 0.94
189_P 225_F 1.156 0.94
324_E 359_R 1.155 0.94
376_D 450_W 1.142 0.93
391_V 396_R 1.136 0.93
71_L 74_A 1.134 0.93
366_H 387_D 1.134 0.93
261_T 277_I 1.133 0.93
197_A 224_S 1.129 0.93
309_K 342_P 1.128 0.93
353_A 424_V 1.12 0.93
357_I 384_V 1.119 0.92
393_P 396_R 1.115 0.92
340_P 380_I 1.111 0.92
233_E 237_T 1.11 0.92
88_V 94_V 1.11 0.92
395_D 398_Q 1.106 0.92
251_R 287_M 1.105 0.92
441_P 445_L 1.104 0.92
258_Q 278_E 1.103 0.92
389_P 445_L 1.101 0.92
303_L 431_H 1.099 0.92
313_L 345_G 1.095 0.91
251_R 289_N 1.091 0.91
210_E 226_N 1.091 0.91
258_Q 281_A 1.082 0.91
249_E 352_S 1.078 0.91
329_G 367_T 1.076 0.90
243_L 291_L 1.076 0.90
256_R 276_R 1.075 0.90
388_G 445_L 1.073 0.90
252_T 256_R 1.071 0.90
385_D 440_S 1.069 0.90
314_W 373_F 1.069 0.90
169_I 173_L 1.062 0.90
333_T 368_K 1.06 0.90
321_A 355_E 1.059 0.89
362_L 365_S 1.052 0.89
241_R 402_P 1.037 0.88
216_Q 221_A 1.036 0.88
321_A 359_R 1.034 0.88
293_V 352_S 1.034 0.88
194_K 220_A 1.03 0.88
368_K 387_D 1.029 0.88
318_L 334_V 1.025 0.87
193_L 225_F 1.023 0.87
200_V 208_H 1.021 0.87
249_E 321_A 1.018 0.87
349_A 353_A 1.016 0.87
424_V 428_I 1.015 0.87
436_K 450_W 1.014 0.87
280_E 294_M 1.012 0.86
198_D 220_A 1.009 0.86
87_L 143_L 1.007 0.86
26_M 30_L 1.002 0.86
315_S 334_V 1.001 0.86
355_E 359_R 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4i5sA20.67181000.432Contact Map0.744
2btzA10.6741000.543Contact Map0.554
4ew8A20.54921000.551Contact Map0.753
3jz3A20.46611000.555Contact Map0.595
2q8gA10.68931000.56Contact Map0.549
2e0aA20.67611000.562Contact Map0.598
2c2aA10.51861000.564Contact Map0.731
4e01A10.70241000.565Contact Map0.593
1y8oA10.71121000.574Contact Map0.575
4gczA20.77021000.579Contact Map0.671

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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