GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
CPXR - Transcriptional regulatory protein CpxR
UniProt: P0AE88 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10020
Length: 232 (225)
Sequences: 27290
Seq/Len: 121.29

CPXR
Paralog alert: 0.94 [within 20: 0.55] - ratio of genomes with paralogs
Cluster includes: ARCA BAER BASR BGLJ CPXR CREB CSGD CUSR DCUR DPIA EVGA FIMZ KDPE NARL NARP OMPR PHOB PHOP QSEB RCSB RSTA TORR UHPA UVRY YEDW YGEK YHJB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
14_T 30_V 3.543 1.00
14_T 32_H 2.838 1.00
35_E 56_K 2.601 1.00
18_K 30_V 2.598 1.00
7_V 37_A 2.466 1.00
33_D 56_K 2.462 1.00
160_T 163_T 2.415 1.00
57_K 65_A 2.344 1.00
195_R 198_D 2.34 1.00
161_E 207_K 2.322 1.00
29_I 45_I 2.315 1.00
83_E 103_N 2.311 1.00
178_R 198_D 2.307 1.00
18_K 22_E 2.283 1.00
34_G 57_K 2.155 1.00
86_R 106_E 2.152 1.00
33_D 36_Q 2.084 1.00
138_A 151_D 2.005 1.00
20_L 104_D 1.999 1.00
3_K 27_N 1.974 1.00
38_L 65_A 1.955 1.00
135_E 140_V 1.905 1.00
58_N 61_D 1.884 1.00
166_Y 170_Q 1.857 1.00
147_E 154_T 1.854 1.00
219_K 229_V 1.818 1.00
32_H 36_Q 1.811 1.00
200_H 203_N 1.803 1.00
47_L 111_I 1.792 1.00
3_K 29_I 1.772 1.00
31_A 40_L 1.763 1.00
76_M 89_G 1.757 1.00
21_L 111_I 1.73 1.00
141_L 169_A 1.727 1.00
75_I 114_I 1.71 1.00
63_L 74_V 1.689 1.00
219_K 227_L 1.684 1.00
52_V 76_M 1.669 1.00
95_D 117_R 1.662 1.00
91_E 112_R 1.657 1.00
140_V 149_S 1.618 1.00
53_M 80_R 1.618 1.00
171_H 174_Q 1.61 1.00
167_L 181_L 1.608 1.00
50_L 62_T 1.604 1.00
50_L 63_L 1.6 1.00
24_E 108_V 1.569 1.00
5_L 31_A 1.548 1.00
63_L 76_M 1.523 1.00
65_A 68_Q 1.509 1.00
48_L 72_T 1.495 1.00
80_R 85_D 1.491 1.00
167_L 184_E 1.483 1.00
177_S 180_H 1.476 1.00
7_V 54_M 1.451 1.00
76_M 94_A 1.446 1.00
34_G 62_T 1.421 1.00
57_K 61_D 1.407 0.99
8_D 14_T 1.393 0.99
60_I 92_L 1.38 0.99
29_I 40_L 1.376 0.99
67_R 95_D 1.37 0.99
38_L 62_T 1.366 0.99
142_N 145_R 1.325 0.99
61_D 64_K 1.323 0.99
96_D 110_R 1.295 0.99
172_L 176_V 1.287 0.99
35_E 57_K 1.281 0.99
146_Q 163_T 1.278 0.99
52_V 60_I 1.27 0.99
42_D 69_T 1.248 0.99
40_L 43_D 1.241 0.98
167_L 176_V 1.237 0.98
26_F 112_R 1.227 0.98
201_I 205_R 1.218 0.98
221_L 227_L 1.214 0.98
143_P 166_Y 1.211 0.98
47_L 115_L 1.204 0.98
35_E 39_D 1.2 0.98
25_G 112_R 1.194 0.98
114_I 117_R 1.19 0.98
149_S 154_T 1.18 0.98
141_L 162_F 1.163 0.97
196_A 200_H 1.163 0.97
38_L 57_K 1.163 0.97
82_S 85_D 1.151 0.97
174_Q 180_H 1.146 0.97
36_Q 39_D 1.134 0.97
31_A 37_A 1.133 0.97
41_L 66_L 1.133 0.97
176_V 184_E 1.124 0.97
11_R 32_H 1.124 0.97
64_K 88_L 1.123 0.97
29_I 43_D 1.111 0.96
158_T 207_K 1.102 0.96
160_T 186_L 1.098 0.96
133_T 140_V 1.097 0.96
144_G 174_Q 1.094 0.96
4_I 26_F 1.094 0.96
24_E 112_R 1.09 0.96
199_M 202_S 1.088 0.96
9_D 51_D 1.087 0.96
84_L 88_L 1.086 0.96
146_Q 224_R 1.085 0.96
179_E 194_D 1.074 0.95
5_L 45_I 1.072 0.95
7_V 48_L 1.069 0.95
36_Q 40_L 1.064 0.95
87_V 105_R 1.061 0.95
113_A 118_S 1.061 0.95
17_L 77_L 1.061 0.95
5_L 37_A 1.054 0.95
60_I 88_L 1.053 0.95
136_V 228_M 1.044 0.94
53_M 79_A 1.034 0.94
6_L 28_V 1.034 0.94
83_E 87_V 1.02 0.93
54_M 62_T 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ys7A20.96981000.059Contact Map0.778
2gwrA10.96551000.068Contact Map0.687
3r0jA20.97411000.071Contact Map0.684
2oqrA10.97411000.072Contact Map0.572
4b09A120.97411000.095Contact Map0.679
1kgsA10.95691000.108Contact Map0.723
1p2fA10.93531000.121Contact Map0.744
2hqrA20.92671000.125Contact Map0.684
3q9sA10.91381000.134Contact Map0.688
3c3wA20.90521000.217Contact Map0.64

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.1705 seconds.