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FEOA - Ferrous iron transport protein A
UniProt: P0AEL3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12101
Length: 75 (70)
Sequences: 997
Seq/Len: 14.24

FEOA
Paralog alert: 0.13 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
3_Y 9_W 4.514 1.00
4_T 7_T 2.138 1.00
10_K 71_E 2.123 1.00
38_N 52_E 2 1.00
8_A 36_S 1.982 1.00
32_L 54_R 1.894 1.00
35_S 54_R 1.704 1.00
10_K 36_S 1.684 1.00
24_Q 28_S 1.667 1.00
12_T 71_E 1.62 1.00
15_S 69_E 1.593 1.00
7_T 72_A 1.583 1.00
8_A 38_N 1.569 1.00
42_V 62_K 1.495 1.00
11_I 68_L 1.49 1.00
37_F 51_I 1.463 1.00
44_P 47_D 1.438 1.00
50_H 57_S 1.43 1.00
39_V 49_I 1.393 0.99
31_M 58_L 1.332 0.99
12_T 15_S 1.288 0.99
29_L 56_V 1.269 0.99
40_V 57_S 1.269 0.99
56_V 59_V 1.249 0.99
12_T 69_E 1.189 0.98
3_Y 70_V 1.167 0.97
52_E 57_S 1.151 0.97
23_R 27_L 1.141 0.97
5_P 41_R 1.114 0.96
43_A 58_L 1.08 0.95
41_R 50_H 1.08 0.95
61_R 64_D 1.051 0.94
51_I 60_L 1.035 0.94
58_L 62_K 1.014 0.93
51_I 58_L 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2k4yA10.973399.60.226Contact Map0.62
2lx9A1199.60.227Contact Map0.549
2k5iA10.973399.60.228Contact Map0.714
2k5lA10.973399.60.23Contact Map0.629
2k5fA10.973399.60.236Contact Map0.661
2gcxA1199.60.247Contact Map0.58
3hrsA20.946799.60.252Contact Map0.671
2h3jA10.986799.50.265Contact Map0.386
3mhxA20.973399.50.281Contact Map0.676
3e19A40.933399.50.3Contact Map0.807

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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