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FEPB - Ferrienterobactin-binding periplasmic protein
UniProt: P0AEL6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10294
Length: 318 (296)
Sequences: 4777
Seq/Len: 16.14

FEPB
Paralog alert: 0.75 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: BTUF FECB FEPB FHUD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
160_G 169_A 5.225 1.00
157_T 170_A 5.18 1.00
258_N 285_P 5.16 1.00
165_H 168_Q 3.864 1.00
161_E 166_E 3.771 1.00
285_P 289_N 3.493 1.00
153_Q 177_D 3.334 1.00
51_S 57_T 3.266 1.00
170_A 174_A 3.245 1.00
174_A 178_K 3.193 1.00
48_R 68_I 3.038 1.00
181_A 185_E 2.949 1.00
34_T 39_T 2.912 1.00
168_Q 171_E 2.835 1.00
157_T 173_I 2.81 1.00
110_A 113_A 2.769 1.00
35_D 40_H 2.763 1.00
50_V 111_V 2.639 1.00
60_L 163_T 2.562 1.00
177_D 181_A 2.523 1.00
32_Q 39_T 2.411 1.00
219_L 224_F 2.407 1.00
260_E 285_P 2.36 1.00
49_I 163_T 2.31 1.00
276_Y 290_K 2.253 1.00
171_E 175_Q 2.2 1.00
178_K 182_A 2.134 1.00
32_Q 41_T 2.085 1.00
31_R 161_E 2.051 1.00
252_N 256_G 2.044 1.00
69_A 114_Q 2.025 1.00
135_Q 138_T 1.999 1.00
179_Q 308_M 1.982 1.00
59_S 156_L 1.936 1.00
182_A 186_Q 1.926 1.00
133_Y 137_S 1.899 1.00
281_L 287_V 1.896 1.00
50_V 69_A 1.858 1.00
106_P 111_V 1.831 1.00
151_S 154_S 1.79 1.00
65_A 163_T 1.781 1.00
120_L 159_L 1.706 1.00
109_E 251_E 1.7 1.00
50_V 114_Q 1.695 1.00
181_A 184_K 1.692 1.00
35_D 38_G 1.69 1.00
179_Q 312_D 1.684 1.00
167_K 171_E 1.672 1.00
67_V 98_L 1.667 1.00
285_P 288_Q 1.667 1.00
261_S 291_Q 1.65 1.00
30_P 41_T 1.624 1.00
63_I 165_H 1.622 1.00
216_G 220_E 1.621 1.00
262_L 286_A 1.619 1.00
99_Q 110_A 1.586 1.00
112_A 139_I 1.578 1.00
157_T 177_D 1.57 1.00
118_L 143_L 1.558 1.00
283_H 288_Q 1.553 1.00
134_D 138_T 1.545 1.00
46_P 117_D 1.535 1.00
261_S 293_Y 1.533 1.00
273_D 277_A 1.528 1.00
284_L 287_V 1.501 1.00
166_E 170_A 1.479 1.00
65_A 165_H 1.474 1.00
174_A 177_D 1.456 1.00
47_Q 117_D 1.408 1.00
35_D 133_Y 1.395 0.99
154_S 157_T 1.388 0.99
308_M 312_D 1.382 0.99
68_I 114_Q 1.382 0.99
42_L 141_P 1.374 0.99
193_P 225_T 1.364 0.99
42_L 45_Q 1.356 0.99
119_I 139_I 1.347 0.99
178_K 181_A 1.34 0.99
143_L 162_I 1.34 0.99
250_G 278_N 1.319 0.99
69_A 102_Y 1.305 0.99
51_S 60_L 1.303 0.99
252_N 257_L 1.301 0.99
273_D 276_Y 1.299 0.99
29_W 164_G 1.298 0.99
175_Q 178_K 1.297 0.99
62_A 172_R 1.286 0.99
227_A 257_L 1.268 0.99
168_Q 172_R 1.264 0.99
285_P 291_Q 1.26 0.99
60_L 67_V 1.25 0.99
180_L 221_Q 1.249 0.99
167_K 170_A 1.228 0.98
121_I 144_I 1.225 0.98
175_Q 179_Q 1.212 0.98
30_P 44_S 1.211 0.98
176_F 221_Q 1.204 0.98
42_L 46_P 1.203 0.98
134_D 137_S 1.202 0.98
313_R 316_A 1.197 0.98
48_R 115_M 1.188 0.98
118_L 162_I 1.185 0.98
107_S 110_A 1.18 0.98
173_I 177_D 1.175 0.98
153_Q 173_I 1.175 0.98
30_P 43_E 1.174 0.98
211_P 220_E 1.164 0.97
49_I 118_L 1.164 0.97
119_I 140_A 1.16 0.97
195_T 260_E 1.143 0.97
182_A 185_E 1.142 0.97
18_L 21_I 1.132 0.97
272_A 276_Y 1.13 0.97
270_K 273_D 1.123 0.97
279_P 282_A 1.116 0.96
137_S 142_T 1.108 0.96
44_S 47_Q 1.104 0.96
60_L 65_A 1.097 0.96
254_A 284_L 1.096 0.96
281_L 284_L 1.093 0.96
172_R 175_Q 1.09 0.96
143_L 158_Q 1.086 0.96
87_R 90_S 1.075 0.95
253_L 284_L 1.071 0.95
158_Q 161_E 1.07 0.95
158_Q 162_I 1.069 0.95
179_Q 315_K 1.067 0.95
195_T 225_T 1.061 0.95
30_P 45_Q 1.056 0.95
156_L 169_A 1.049 0.94
191_P 225_T 1.047 0.94
61_L 67_V 1.04 0.94
309_Q 312_D 1.037 0.94
63_I 169_A 1.037 0.94
196_A 219_L 1.032 0.94
49_I 60_L 1.031 0.94
179_Q 183_A 1.024 0.93
56_L 120_L 1.017 0.93
50_V 119_I 1.016 0.93
35_D 39_T 1.011 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tlkA311000.166Contact Map0.735
3r5tA10.89311000.241Contact Map0.744
3tefA10.83651000.264Contact Map0.75
4hn9A20.88051000.267Contact Map0.762
3gfvA20.87421000.268Contact Map0.753
3tnyA10.88681000.27Contact Map0.748
4mlzA20.88991000.274Contact Map0.692
3lhsA10.87741000.274Contact Map0.722
3zkwA20.84911000.282Contact Map0.793
3pshA10.83331000.287Contact Map0.752

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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