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FKBX - FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase
UniProt: P0AEM0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11080
Length: 149 (143)
Sequences: 1361
Seq/Len: 9.52

FKBX
Paralog alert: 0.60 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FKBX SLYD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_P 133_T 4.399 1.00
60_K 139_E 3.886 1.00
68_D 73_V 3.274 1.00
50_Q 69_A 3.172 1.00
62_T 137_D 3.1 1.00
55_L 61_T 2.528 1.00
17_L 25_A 2.365 1.00
51_H 63_F 2.217 1.00
56_K 59_D 2.206 1.00
66_E 133_T 2.196 1.00
9_S 145_P 2.027 1.00
57_V 142_E 1.98 1.00
66_E 69_A 1.927 1.00
5_V 39_L 1.919 1.00
87_F 121_I 1.85 1.00
12_L 142_E 1.843 1.00
81_Y 120_S 1.83 1.00
7_S 53_L 1.816 1.00
20_D 135_H 1.767 1.00
16_T 27_S 1.746 1.00
111_G 125_F 1.72 1.00
57_V 143_I 1.711 1.00
84_R 121_I 1.697 1.00
60_K 137_D 1.641 1.00
14_H 139_E 1.607 1.00
65_L 70_A 1.602 1.00
95_I 116_I 1.598 1.00
5_V 140_V 1.57 1.00
55_L 59_D 1.562 1.00
10_A 144_D 1.56 1.00
74_P 79_I 1.554 1.00
16_T 137_D 1.523 1.00
13_V 48_L 1.51 1.00
4_S 56_K 1.502 1.00
14_H 28_T 1.499 1.00
81_Y 122_T 1.451 1.00
115_E 122_T 1.411 0.99
37_F 52_L 1.401 0.99
111_G 123_V 1.391 0.99
45_S 65_L 1.383 0.99
12_L 36_L 1.322 0.99
64_S 133_T 1.312 0.99
16_T 24_T 1.311 0.99
84_R 119_D 1.293 0.99
14_H 27_S 1.278 0.99
39_L 49_E 1.273 0.99
64_S 135_H 1.272 0.99
10_A 38_R 1.266 0.99
46_E 50_Q 1.244 0.98
101_F 111_G 1.222 0.98
39_L 53_L 1.222 0.98
94_E 97_A 1.213 0.98
44_L 48_L 1.204 0.98
5_V 143_I 1.198 0.98
80_Q 83_S 1.181 0.97
6_Q 9_S 1.179 0.97
41_D 49_E 1.156 0.97
62_T 135_H 1.152 0.97
45_S 71_F 1.146 0.97
9_S 143_I 1.142 0.97
5_V 54_G 1.138 0.97
71_F 134_V 1.125 0.96
16_T 29_R 1.124 0.96
19_L 25_A 1.121 0.96
18_K 24_T 1.104 0.96
79_I 122_T 1.102 0.96
19_L 23_T 1.088 0.95
14_H 29_R 1.069 0.95
20_D 133_T 1.065 0.94
11_V 143_I 1.045 0.94
20_D 64_S 1.045 0.94
8_N 41_D 1.042 0.94
48_L 138_I 1.035 0.93
61_T 138_I 1.011 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dt4A111000.102Contact Map0.786
2kfwA10.97321000.12Contact Map0.682
2k8iA10.97321000.123Contact Map0.73
2kr7A10.97991000.139Contact Map0.671
3cgmA10.94631000.154Contact Map0.865
1ix5A10.91951000.18Contact Map0.834
3prbA20.93961000.194Contact Map0.915
3pr9A10.93961000.199Contact Map0.918
2lknA10.919599.90.487Contact Map0.679
1kt0A10.979999.80.542Contact Map0.483

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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