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FLIY - Cystine-binding periplasmic protein
UniProt: P0AEM9 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12680
Length: 266 (234)
Sequences: 10521
Seq/Len: 44.96

FLIY
Paralog alert: 0.90 [within 20: 0.42] - ratio of genomes with paralogs
Cluster includes: ARGT ARTI ARTJ FLIY GLNH GLTI HISJ YHDW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
153_G 191_I 3.826 1.00
46_G 101_I 3.551 1.00
42_T 83_S 3.526 1.00
77_H 245_E 3.087 1.00
122_T 244_A 2.641 1.00
176_Y 185_D 2.523 1.00
112_D 115_K 2.503 1.00
110_I 225_G 2.451 1.00
251_T 254_A 2.418 1.00
44_L 83_S 2.385 1.00
253_Q 257_E 2.33 1.00
42_T 81_E 2.265 1.00
110_I 115_K 2.258 1.00
236_L 240_N 2.257 1.00
95_S 101_I 2.201 1.00
244_A 248_K 2.165 1.00
142_K 146_D 2.141 1.00
75_A 82_A 2.141 1.00
118_Y 227_A 2.139 1.00
143_T 146_D 2.13 1.00
178_D 181_T 2.125 1.00
44_L 85_K 2.102 1.00
161_E 175_T 2.066 1.00
151_K 174_R 2.041 1.00
73_Q 76_K 2.026 1.00
228_L 236_L 2.009 1.00
228_L 239_V 1.99 1.00
58_G 64_T 1.966 1.00
161_E 165_R 1.943 1.00
196_V 201_A 1.934 1.00
151_K 172_D 1.922 1.00
119_D 236_L 1.919 1.00
73_Q 251_T 1.912 1.00
122_T 240_N 1.909 1.00
97_D 117_K 1.905 1.00
229_R 232_N 1.801 1.00
69_E 258_K 1.781 1.00
73_Q 246_M 1.735 1.00
77_H 249_D 1.731 1.00
73_Q 77_H 1.714 1.00
105_I 226_V 1.673 1.00
58_G 62_K 1.658 1.00
237_K 241_D 1.645 1.00
182_K 194_I 1.629 1.00
119_D 231_G 1.618 1.00
69_E 259_W 1.608 1.00
233_E 237_K 1.605 1.00
77_H 242_A 1.604 1.00
121_S 240_N 1.598 1.00
45_V 71_A 1.529 1.00
150_K 192_D 1.476 1.00
95_S 100_R 1.472 1.00
134_K 137_N 1.456 1.00
113_E 116_K 1.406 0.99
126_I 223_E 1.38 0.99
156_L 177_D 1.379 0.99
45_V 103_V 1.371 0.99
238_A 241_D 1.37 0.99
35_N 39_E 1.367 0.99
152_V 193_A 1.363 0.99
121_S 239_V 1.36 0.99
241_D 245_E 1.357 0.99
185_D 190_R 1.357 0.99
72_Q 84_L 1.347 0.99
104_V 108_V 1.319 0.99
67_E 124_Y 1.314 0.99
177_D 181_T 1.298 0.99
186_L 191_I 1.296 0.99
99_K 229_R 1.292 0.99
92_M 104_V 1.282 0.99
56_F 64_T 1.275 0.99
78_L 242_A 1.27 0.99
119_D 233_E 1.26 0.99
93_L 118_Y 1.245 0.98
87_T 95_S 1.241 0.98
66_F 255_L 1.238 0.98
151_K 192_D 1.235 0.98
103_V 228_L 1.232 0.98
145_D 148_K 1.228 0.98
245_E 249_D 1.225 0.98
186_L 194_I 1.209 0.98
163_W 167_N 1.206 0.98
198_R 202_L 1.199 0.98
62_K 72_Q 1.199 0.98
162_E 166_Q 1.197 0.98
103_V 239_V 1.197 0.98
132_L 201_A 1.196 0.98
155_G 158_T 1.193 0.98
238_A 242_A 1.192 0.98
251_T 255_L 1.185 0.98
153_G 176_Y 1.179 0.98
77_H 246_M 1.173 0.98
74_L 242_A 1.172 0.98
185_D 191_I 1.166 0.97
71_A 105_I 1.149 0.97
88_K 91_G 1.141 0.97
242_A 245_E 1.132 0.97
57_Q 86_P 1.129 0.97
70_F 252_L 1.126 0.97
70_F 246_M 1.126 0.97
68_V 72_Q 1.123 0.97
66_F 260_F 1.119 0.96
66_F 256_S 1.116 0.96
69_E 72_Q 1.111 0.96
108_V 227_A 1.105 0.96
111_S 114_R 1.102 0.96
247_Q 252_L 1.088 0.96
186_L 212_L 1.078 0.95
72_Q 76_K 1.077 0.95
242_A 246_M 1.076 0.95
54_F 125_T 1.074 0.95
176_Y 182_K 1.074 0.95
119_D 230_K 1.073 0.95
153_G 182_K 1.071 0.95
165_R 175_T 1.069 0.95
71_A 84_L 1.066 0.95
128_G 198_R 1.055 0.95
131_A 193_A 1.051 0.94
45_V 82_A 1.046 0.94
94_A 97_D 1.041 0.94
49_G 86_P 1.022 0.93
96_L 104_V 1.012 0.93
184_Q 187_R 1.009 0.93
136_G 213_A 1.006 0.93
246_M 251_T 1.002 0.92
147_L 193_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kbrA10.88351000.295Contact Map0.805
2ylnA10.97741000.298Contact Map0.82
3hv1A20.91731000.299Contact Map0.797
3vv5A20.96621000.3Contact Map0.873
2ieeA20.91731000.3Contact Map0.825
4i62A10.97741000.3Contact Map0.768
4h5gA20.88721000.301Contact Map0.839
1xt8A20.98121000.302Contact Map0.869
2yjpA30.98871000.304Contact Map0.854
3k4uA60.86471000.306Contact Map0.844

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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