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GALU - UTP--glucose-1-phosphate uridylyltransferase
UniProt: P0AEP3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11319
Length: 302 (282)
Sequences: 5658
Seq/Len: 20.06

GALU
Paralog alert: 0.78 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: GALF GALU RMLA1 RMLA2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
123_H 229_A 4.91 1.00
113_K 117_H 3.41 1.00
56_E 103_T 3.355 1.00
107_V 121_C 3.291 1.00
171_P 211_N 3.268 1.00
182_D 197_V 2.913 1.00
227_L 251_K 2.751 1.00
11_A 54_I 2.73 1.00
227_L 247_M 2.719 1.00
61_T 65_K 2.587 1.00
158_R 257_Y 2.546 1.00
169_V 256_A 2.52 1.00
227_L 244_A 2.466 1.00
195_P 255_E 2.423 1.00
247_M 250_E 2.364 1.00
174_D 177_A 2.315 1.00
57_I 102_V 2.287 1.00
246_D 250_E 2.282 1.00
223_D 226_P 2.279 1.00
15_V 59_L 2.251 1.00
247_M 251_K 2.23 1.00
182_D 198_G 2.23 1.00
243_D 246_D 2.225 1.00
171_P 258_H 2.225 1.00
184_K 195_P 2.172 1.00
200_V 209_P 2.091 1.00
157_R 161_E 2.076 1.00
223_D 253_T 2.04 1.00
223_D 251_K 2.007 1.00
120_L 123_H 1.904 1.00
65_K 108_R 1.853 1.00
46_V 57_I 1.835 1.00
67_S 70_N 1.832 1.00
277_V 290_F 1.829 1.00
130_P 221_S 1.816 1.00
162_T 255_E 1.753 1.00
220_L 245_I 1.662 1.00
245_I 254_V 1.66 1.00
143_Y 154_E 1.647 1.00
23_L 27_K 1.635 1.00
159_F 166_Q 1.632 1.00
181_V 196_M 1.619 1.00
196_M 256_A 1.613 1.00
198_G 246_D 1.597 1.00
155_M 219_V 1.58 1.00
226_P 230_K 1.578 1.00
153_A 157_R 1.575 1.00
163_G 253_T 1.565 1.00
11_A 49_C 1.544 1.00
10_K 56_E 1.533 1.00
154_E 157_R 1.519 1.00
195_P 253_T 1.519 1.00
127_G 222_A 1.507 1.00
39_K 47_N 1.499 1.00
123_H 225_W 1.496 1.00
230_K 247_M 1.496 1.00
204_K 207_V 1.485 1.00
158_R 162_T 1.474 1.00
61_T 66_N 1.465 1.00
43_Q 71_H 1.465 1.00
117_H 121_C 1.455 1.00
42_I 59_L 1.445 1.00
22_M 26_T 1.443 1.00
43_Q 47_N 1.439 1.00
169_V 181_V 1.434 1.00
130_P 222_A 1.411 1.00
66_N 70_N 1.411 1.00
287_G 291_K 1.411 1.00
54_I 156_I 1.389 0.99
46_V 104_I 1.383 0.99
223_D 227_L 1.383 0.99
199_V 214_I 1.374 0.99
175_V 205_A 1.359 0.99
49_C 134_I 1.341 0.99
59_L 72_F 1.336 0.99
231_T 243_D 1.332 0.99
120_L 229_A 1.323 0.99
29_I 67_S 1.32 0.99
212_L 258_H 1.319 0.99
244_A 247_M 1.316 0.99
184_K 193_S 1.308 0.99
141_D 282_R 1.301 0.99
58_V 125_V 1.296 0.99
270_L 274_Q 1.294 0.99
158_R 166_Q 1.289 0.99
130_P 160_D 1.281 0.99
83_E 95_Q 1.274 0.99
42_I 68_I 1.267 0.99
105_M 125_V 1.263 0.99
164_H 221_S 1.257 0.99
222_A 225_W 1.256 0.99
66_N 69_E 1.251 0.99
273_M 276_F 1.246 0.98
223_D 252_E 1.246 0.98
182_D 200_V 1.241 0.98
58_V 122_A 1.238 0.98
126_V 225_W 1.225 0.98
25_A 28_A 1.215 0.98
231_T 247_M 1.183 0.98
21_R 31_K 1.177 0.98
180_V 213_A 1.174 0.98
172_V 175_V 1.174 0.98
272_Y 276_F 1.165 0.97
54_I 132_A 1.163 0.97
65_K 69_E 1.137 0.97
36_L 139_I 1.135 0.97
164_H 255_E 1.133 0.97
158_R 255_E 1.128 0.97
128_D 222_A 1.126 0.97
33_M 67_S 1.12 0.96
183_C 212_L 1.11 0.96
182_D 209_P 1.106 0.96
115_L 135_L 1.101 0.96
196_M 254_V 1.096 0.96
120_L 239_I 1.093 0.96
165_S 254_V 1.092 0.96
141_D 279_Y 1.089 0.96
126_V 131_V 1.085 0.96
80_A 84_K 1.079 0.95
156_I 219_V 1.077 0.95
290_F 294_L 1.071 0.95
9_K 55_T 1.069 0.95
129_E 222_A 1.068 0.95
131_V 222_A 1.046 0.94
92_D 96_S 1.043 0.94
179_G 201_E 1.032 0.94
41_L 266_C 1.03 0.94
176_T 204_K 1.03 0.94
185_G 193_S 1.028 0.94
119_V 133_V 1.028 0.94
273_M 278_E 1.018 0.93
154_E 158_R 1.018 0.93
19_G 31_K 1.017 0.93
181_V 256_A 1.017 0.93
155_M 168_M 1.013 0.93
143_Y 153_A 1.008 0.93
22_M 34_L 1.004 0.93
289_E 292_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2e3dA40.99671000.301Contact Map0.861
2ux8A80.95031000.358Contact Map0.753
2pa4A40.97351000.365Contact Map0.755
3jukA40.92381000.392Contact Map0.822
1iimA20.84441000.421Contact Map0.764
1fxoA80.84441000.432Contact Map0.783
1mc3A20.84771000.435Contact Map0.667
4ecmA10.82121000.442Contact Map0.698
1lvwA40.84441000.443Contact Map0.8
4ho4A20.83771000.443Contact Map0.775

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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