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GLTJ - Glutamate/aspartate transport system permease protein GltJ
UniProt: P0AER3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12661
Length: 246 (225)
Sequences: 7984
Seq/Len: 35.48

GLTJ
Paralog alert: 0.91 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
42_I 119_G 3.63 1.00
114_S 186_A 3.493 1.00
173_T 230_M 3.093 1.00
151_T 154_Q 2.953 1.00
207_H 210_E 2.922 1.00
145_A 155_A 2.867 1.00
53_L 65_G 2.817 1.00
30_Q 34_A 2.722 1.00
198_A 215_I 2.716 1.00
75_V 80_Q 2.664 1.00
50_F 123_A 2.526 1.00
142_K 155_A 2.441 1.00
153_P 157_R 2.403 1.00
141_Q 163_N 2.396 1.00
60_F 64_L 2.371 1.00
60_F 63_G 2.225 1.00
50_F 127_C 2.202 1.00
51_G 130_V 2.18 1.00
36_S 180_V 2.141 1.00
133_A 168_I 2.114 1.00
69_V 127_C 2.1 1.00
228_L 232_L 2.024 1.00
54_R 66_T 1.934 1.00
136_S 167_V 1.914 1.00
220_V 224_A 1.869 1.00
142_K 146_L 1.805 1.00
38_C 115_M 1.8 1.00
196_A 200_K 1.758 1.00
31_V 34_A 1.756 1.00
36_S 183_S 1.753 1.00
29_F 222_I 1.748 1.00
26_W 30_Q 1.74 1.00
46_V 123_A 1.738 1.00
146_L 155_A 1.737 1.00
126_V 172_M 1.718 1.00
34_A 111_F 1.696 1.00
84_W 117_C 1.689 1.00
202_L 208_A 1.646 1.00
224_A 228_L 1.644 1.00
232_L 235_R 1.638 1.00
55_T 134_I 1.612 1.00
40_W 176_M 1.549 1.00
35_L 186_A 1.528 1.00
151_T 155_A 1.518 1.00
75_V 121_F 1.514 1.00
229_V 232_L 1.503 1.00
228_L 231_T 1.497 1.00
198_A 211_S 1.489 1.00
59_R 63_G 1.486 1.00
72_F 120_L 1.481 1.00
27_S 30_Q 1.461 1.00
111_F 115_M 1.46 1.00
42_I 115_M 1.452 1.00
128_E 131_R 1.443 1.00
152_L 156_Y 1.441 1.00
80_Q 121_F 1.44 1.00
48_S 130_V 1.429 1.00
55_T 135_Q 1.424 1.00
229_V 233_V 1.407 0.99
50_F 65_G 1.396 0.99
109_Q 112_L 1.391 0.99
49_F 53_L 1.389 0.99
150_L 154_Q 1.381 0.99
81_F 117_C 1.372 0.99
53_L 56_V 1.361 0.99
154_Q 158_Y 1.355 0.99
59_R 62_S 1.343 0.99
58_N 63_G 1.32 0.99
186_A 193_D 1.265 0.99
154_Q 157_R 1.265 0.99
54_R 128_E 1.242 0.98
126_V 175_E 1.213 0.98
130_V 168_I 1.211 0.98
38_C 119_G 1.202 0.98
53_L 61_L 1.2 0.98
31_V 191_L 1.196 0.98
232_L 236_K 1.193 0.98
184_A 219_Y 1.19 0.98
64_L 67_L 1.189 0.98
202_L 212_F 1.185 0.98
34_A 38_C 1.18 0.98
146_L 152_L 1.176 0.98
47_G 126_V 1.168 0.97
43_A 122_T 1.158 0.97
41_I 45_L 1.137 0.97
192_V 196_A 1.135 0.97
45_L 49_F 1.135 0.97
137_L 167_V 1.13 0.97
63_G 67_L 1.13 0.97
131_R 135_Q 1.113 0.96
178_N 182_N 1.105 0.96
180_V 226_I 1.104 0.96
62_S 66_T 1.104 0.96
142_K 160_L 1.088 0.96
150_L 158_Y 1.074 0.95
70_E 224_A 1.074 0.95
145_A 159_V 1.073 0.95
196_A 199_G 1.069 0.95
39_A 119_G 1.061 0.95
225_F 229_V 1.059 0.95
129_Q 175_E 1.053 0.95
197_Q 200_K 1.051 0.94
111_F 191_L 1.051 0.94
64_L 68_Y 1.026 0.94
112_L 116_L 1.024 0.93
217_L 221_L 1.022 0.93
156_Y 161_L 1.02 0.93
180_V 222_I 1.019 0.93
81_F 186_A 1.007 0.93
134_I 160_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.853799.90.634Contact Map0.78
2onkC40.93599.90.655Contact Map0.589
3rlfF10.959399.90.656Contact Map0.624
3d31C20.930999.90.665Contact Map0.546
3rlfG10.955399.80.683Contact Map0.498
3e7lA40.25616.30.963Contact Map0.588
2m8gX10.26834.80.965Contact Map0.472
3zjzA40.44313.90.967Contact Map0.316
1g2hA10.24830.968Contact Map0.381
4ltoA40.47562.80.969Contact Map0.572

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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