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HISM - Histidine transport system permease protein HisM
UniProt: P0AEU3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10007
Length: 238 (223)
Sequences: 8047
Seq/Len: 36.09

HISM
Paralog alert: 0.91 [within 20: 0.54] - ratio of genomes with paralogs
Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
36_I 110_T 3.561 1.00
105_T 177_A 3.487 1.00
164_S 221_F 3.073 1.00
198_Q 201_T 2.951 1.00
142_S 145_K 2.936 1.00
47_G 59_I 2.812 1.00
136_A 146_M 2.81 1.00
189_A 206_A 2.726 1.00
24_A 28_W 2.669 1.00
69_T 74_Q 2.647 1.00
44_L 114_C 2.5 1.00
133_I 146_M 2.397 1.00
132_E 154_S 2.384 1.00
144_F 148_R 2.346 1.00
54_Y 58_P 2.337 1.00
54_Y 57_F 2.183 1.00
30_L 171_L 2.162 1.00
45_A 121_F 2.159 1.00
44_L 118_T 2.129 1.00
63_T 118_T 2.084 1.00
124_A 159_A 2.068 1.00
219_S 223_R 1.943 1.00
48_R 60_W 1.914 1.00
127_S 158_I 1.911 1.00
211_L 215_Y 1.876 1.00
23_V 213_I 1.783 1.00
187_K 191_D 1.774 1.00
25_I 28_W 1.752 1.00
30_L 174_T 1.742 1.00
40_L 114_C 1.739 1.00
32_L 106_V 1.735 1.00
133_I 137_R 1.731 1.00
117_T 163_Y 1.703 1.00
78_F 108_A 1.689 1.00
193_N 199_P 1.682 1.00
137_R 146_M 1.68 1.00
28_W 102_L 1.665 1.00
100_S 103_N 1.627 1.00
223_R 226_K 1.618 1.00
215_Y 219_S 1.601 1.00
49_V 125_I 1.593 1.00
34_V 167_V 1.535 1.00
69_T 112_N 1.51 1.00
29_L 177_A 1.5 1.00
142_S 146_M 1.492 1.00
143_T 147_Y 1.488 1.00
220_L 223_R 1.487 1.00
219_S 222_R 1.487 1.00
74_Q 112_N 1.479 1.00
189_A 202_A 1.472 1.00
66_F 111_L 1.448 1.00
42_L 121_F 1.431 1.00
102_L 106_V 1.43 1.00
53_K 57_F 1.422 1.00
49_V 126_R 1.413 1.00
220_L 224_A 1.394 0.99
36_I 106_V 1.394 0.99
44_L 59_I 1.39 0.99
141_F 145_K 1.376 0.99
119_E 122_A 1.374 0.99
75_L 108_A 1.37 0.99
47_G 50_S 1.363 0.99
43_F 47_G 1.348 0.99
145_K 149_C 1.347 0.99
52_N 57_F 1.327 0.99
53_K 56_Q 1.281 0.99
145_K 148_R 1.266 0.99
177_A 184_D 1.265 0.99
25_I 182_V 1.243 0.98
223_R 227_R 1.24 0.98
193_N 203_F 1.217 0.98
175_A 210_Y 1.216 0.98
32_L 110_T 1.205 0.98
48_R 119_E 1.194 0.98
37_G 113_T 1.187 0.98
121_F 159_A 1.187 0.98
137_R 143_T 1.18 0.98
117_T 166_E 1.173 0.98
41_A 117_T 1.168 0.97
47_G 55_I 1.158 0.97
39_V 43_F 1.149 0.97
28_W 32_L 1.147 0.97
58_P 61_L 1.139 0.97
57_F 61_L 1.127 0.97
171_L 217_L 1.121 0.97
183_P 187_K 1.121 0.97
35_V 39_V 1.109 0.96
128_V 158_I 1.106 0.96
141_F 149_C 1.094 0.96
169_L 173_S 1.093 0.96
122_A 126_R 1.086 0.96
64_Y 215_Y 1.077 0.95
227_R 230_Q 1.074 0.95
33_S 110_T 1.061 0.95
56_Q 60_W 1.061 0.95
136_A 150_I 1.056 0.95
120_I 166_E 1.055 0.95
187_K 190_R 1.045 0.94
133_I 151_I 1.04 0.94
188_I 191_D 1.037 0.94
208_V 212_I 1.035 0.94
58_P 62_F 1.03 0.94
20_F 24_A 1.029 0.94
147_Y 152_L 1.028 0.94
75_L 177_A 1.027 0.94
103_N 107_L 1.026 0.94
61_L 65_I 1.023 0.93
102_L 182_V 1.015 0.93
171_L 213_I 1.009 0.93
74_Q 78_F 1 0.92
66_F 115_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.882499.90.623Contact Map0.782
2onkC40.966499.90.648Contact Map0.59
3d31C20.962299.90.656Contact Map0.541
3rlfF10.966499.90.657Contact Map0.614
3rlfG10.962299.80.683Contact Map0.493
3e7lA40.264770.962Contact Map0.608
4f4lA40.336150.965Contact Map0.278
3zjzA40.46224.90.965Contact Map0.344
1g2hA10.25632.80.969Contact Map0.393
4l5eA10.19332.80.969Contact Map0.524

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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