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CPDA - 3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
UniProt: P0AEW4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12187
Length: 275 (256)
Sequences: 1892
Seq/Len: 7.39

CPDA
Paralog alert: 0.26 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
148_E 192_K 3.97 1.00
17_I 58_L 3.63 1.00
16_R 247_E 3.556 1.00
162_L 200_L 2.97 1.00
140_S 182_N 2.711 1.00
129_S 163_L 2.7 1.00
19_Q 62_T 2.689 1.00
60_V 162_L 2.597 1.00
18_L 49_I 2.54 1.00
48_A 243_W 2.403 1.00
62_T 162_L 2.401 1.00
117_F 123_Q 2.363 1.00
115_R 150_K 2.344 1.00
123_Q 150_K 2.317 1.00
66_A 73_A 2.261 1.00
190_L 215_R 2.229 1.00
148_E 193_F 2.163 1.00
50_R 85_R 2.116 1.00
125_L 147_L 2.094 1.00
91_L 126_L 2.076 1.00
117_F 157_R 1.991 1.00
129_S 165_H 1.989 1.00
46_L 50_R 1.985 1.00
200_L 246_L 1.975 1.00
138_E 181_R 1.96 1.00
46_L 84_F 1.951 1.00
58_L 89_V 1.938 1.00
182_N 185_E 1.937 1.00
17_I 246_L 1.932 1.00
163_L 199_L 1.884 1.00
65_L 77_F 1.868 1.00
141_E 145_E 1.843 1.00
146_W 150_K 1.83 1.00
125_L 150_K 1.804 1.00
116_V 124_I 1.797 1.00
18_L 245_T 1.795 1.00
211_D 214_G 1.776 1.00
160_L 198_Y 1.76 1.00
43_Q 83_S 1.742 1.00
124_I 160_L 1.72 1.00
77_F 81_I 1.684 1.00
122_W 248_L 1.684 1.00
141_E 185_E 1.684 1.00
144_L 185_E 1.682 1.00
150_K 153_D 1.682 1.00
61_A 90_W 1.65 1.00
144_L 189_V 1.64 1.00
61_A 77_F 1.638 1.00
115_R 123_Q 1.636 1.00
148_E 189_V 1.628 1.00
114_K 126_L 1.618 1.00
78_A 82_A 1.609 1.00
117_F 150_K 1.545 1.00
43_Q 80_G 1.542 1.00
140_S 143_Q 1.534 1.00
113_A 143_Q 1.489 0.99
147_L 151_L 1.479 0.99
52_H 56_F 1.465 0.99
15_V 124_I 1.457 0.99
209_D 216_R 1.43 0.99
186_L 190_L 1.427 0.99
21_T 62_T 1.425 0.99
220_T 244_R 1.375 0.99
70_S 73_A 1.362 0.99
123_Q 157_R 1.353 0.99
201_C 219_A 1.337 0.98
160_L 200_L 1.3 0.98
148_E 152_A 1.291 0.98
20_I 61_A 1.287 0.98
21_T 220_T 1.244 0.97
126_L 162_L 1.244 0.97
23_T 61_A 1.238 0.97
249_H 255_T 1.22 0.97
127_L 147_L 1.215 0.97
161_L 190_L 1.207 0.96
137_G 165_H 1.19 0.96
123_Q 159_T 1.183 0.96
151_L 161_L 1.177 0.96
114_K 146_W 1.176 0.96
89_V 114_K 1.154 0.95
186_L 199_L 1.152 0.95
167_P 201_C 1.147 0.95
21_T 24_H 1.141 0.95
145_E 149_R 1.14 0.95
51_P 149_R 1.137 0.94
62_T 91_L 1.135 0.94
19_Q 200_L 1.135 0.94
115_R 125_L 1.129 0.94
152_A 193_F 1.125 0.94
204_I 219_A 1.125 0.94
23_T 81_I 1.109 0.93
20_I 45_V 1.098 0.93
18_L 56_F 1.075 0.92
20_I 49_I 1.072 0.92
14_R 249_H 1.071 0.92
121_Q 157_R 1.07 0.92
66_A 69_Q 1.066 0.92
80_G 83_S 1.065 0.91
56_F 86_A 1.058 0.91
147_L 189_V 1.057 0.91
207_E 221_P 1.052 0.91
160_L 248_L 1.044 0.90
21_T 61_A 1.041 0.90
71_S 75_Q 1.035 0.90
39_W 76_H 1.033 0.90
75_Q 79_E 1.031 0.90
121_Q 158_H 1.021 0.89
167_P 186_L 1.015 0.89
125_L 151_L 1.01 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3d03A60.92361000.383Contact Map0.852
3ib7A10.98551000.402Contact Map0.725
2nxfA10.88731000.436Contact Map0.798
3tghA10.89821000.494Contact Map0.67
1uteA10.93091000.499Contact Map0.672
2xmoA20.93821000.528Contact Map0.716
1xzwA20.91271000.539Contact Map0.724
2qfpA40.91271000.549Contact Map0.76
2yeqA20.93451000.55Contact Map0.682
2yvtA10.78911000.561Contact Map0.534

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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