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MTNN - 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
UniProt: P0AF12 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11090
Length: 232 (228)
Sequences: 2892
Seq/Len: 12.68

MTNN
Paralog alert: 0.69 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: DEOD MTNN UDP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_N 37_Q 3.434 1.00
77_A 195_I 3.199 1.00
63_L 187_V 2.819 1.00
182_C 189_F 2.725 1.00
52_K 149_D 2.681 1.00
146_V 168_A 2.353 1.00
122_D 188_P 2.322 1.00
70_V 188_P 2.309 1.00
90_V 170_A 2.288 1.00
160_K 164_N 2.203 1.00
4_G 62_L 2.203 1.00
175_A 191_V 2.145 1.00
127_A 130_E 2.124 1.00
84_L 141_V 1.921 1.00
157_G 160_K 1.909 1.00
94_E 120_K 1.907 1.00
94_E 144_L 1.9 1.00
92_S 145_I 1.866 1.00
126_I 129_A 1.846 1.00
5_I 16_L 1.839 1.00
93_D 142_R 1.805 1.00
37_Q 42_E 1.789 1.00
69_D 187_V 1.74 1.00
77_A 170_A 1.728 1.00
7_G 13_V 1.694 1.00
61_L 64_E 1.687 1.00
127_A 131_A 1.686 1.00
60_T 185_F 1.68 1.00
59_A 71_I 1.669 1.00
98_H 148_G 1.657 1.00
52_K 177_A 1.614 1.00
53_V 149_D 1.594 1.00
172_E 175_A 1.581 1.00
60_T 64_E 1.561 1.00
81_A 169_I 1.547 1.00
90_V 195_I 1.525 1.00
80_L 171_V 1.511 1.00
130_E 134_A 1.501 1.00
52_K 147_S 1.496 1.00
24_Q 35_T 1.496 1.00
170_A 195_I 1.485 1.00
129_A 190_V 1.477 1.00
63_L 71_I 1.458 1.00
64_E 185_F 1.453 1.00
126_I 130_E 1.445 1.00
10_E 47_K 1.421 1.00
85_K 88_D 1.411 1.00
130_E 142_R 1.407 0.99
90_V 169_I 1.405 0.99
71_I 187_V 1.39 0.99
3_I 226_V 1.378 0.99
125_L 190_V 1.372 0.99
27_S 32_E 1.37 0.99
123_D 126_I 1.356 0.99
14_T 18_D 1.341 0.99
46_L 58_G 1.331 0.99
154_G 157_G 1.315 0.99
59_A 178_I 1.306 0.99
94_E 118_G 1.297 0.99
91_V 140_A 1.295 0.99
77_A 193_R 1.289 0.99
208_D 211_L 1.273 0.99
128_A 132_C 1.271 0.99
71_I 182_C 1.267 0.99
55_A 178_I 1.266 0.99
81_A 84_L 1.254 0.99
129_A 132_C 1.253 0.99
147_S 175_A 1.238 0.98
113_P 116_P 1.23 0.98
91_V 221_M 1.225 0.98
123_D 127_A 1.221 0.98
205_L 208_D 1.204 0.98
145_I 170_A 1.201 0.98
20_I 45_L 1.198 0.98
159_A 162_R 1.19 0.98
37_Q 40_G 1.187 0.98
123_D 130_E 1.18 0.98
91_V 126_I 1.167 0.97
8_A 73_N 1.161 0.97
173_M 203_S 1.161 0.97
125_L 129_A 1.154 0.97
95_A 191_V 1.153 0.97
13_V 34_Y 1.147 0.97
63_L 68_P 1.144 0.97
112_L 115_C 1.139 0.97
35_T 44_A 1.139 0.97
20_I 36_G 1.132 0.97
143_G 169_I 1.128 0.97
73_N 178_I 1.125 0.97
52_K 99_D 1.122 0.97
79_G 198_V 1.122 0.97
97_Y 180_H 1.102 0.96
211_L 214_A 1.099 0.96
36_G 43_V 1.092 0.96
141_V 169_I 1.09 0.96
13_V 45_L 1.087 0.96
95_A 179_A 1.085 0.96
79_G 195_I 1.084 0.96
109_Y 164_N 1.079 0.95
126_I 142_R 1.078 0.95
39_N 227_Q 1.069 0.95
127_A 134_A 1.067 0.95
11_E 209_E 1.064 0.95
105_F 108_E 1.063 0.95
33_I 44_A 1.063 0.95
126_I 190_V 1.063 0.95
55_A 177_A 1.061 0.95
24_Q 42_E 1.061 0.95
224_S 227_Q 1.06 0.95
26_I 35_T 1.044 0.94
151_F 173_M 1.042 0.94
51_G 173_M 1.039 0.94
224_S 228_K 1.03 0.94
95_A 175_A 1.029 0.94
145_I 193_R 1.027 0.94
159_A 163_H 1.025 0.93
83_T 141_V 1.024 0.93
179_A 189_F 1.018 0.93
124_K 127_A 1.017 0.93
128_A 131_A 1.014 0.93
21_E 37_Q 1.009 0.93
135_E 228_K 1.004 0.93
19_K 223_E 1.002 0.92
15_L 219_S 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dp9A20.99141000.167Contact Map0.827
1zosA60.99141000.169Contact Map0.809
3bl6A10.98711000.169Contact Map0.786
4f1wA211000.177Contact Map0.855
4kn5A20.99141000.181Contact Map0.812
3nm6B10.98281000.182Contact Map0.788
4l0mA10.98711000.183Contact Map0.79
4g41A20.99571000.184Contact Map0.825
4josA20.97841000.186Contact Map0.836
3eeiA20.98711000.186Contact Map0.814

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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