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YECS - Inner membrane amino-acid ABC transporter permease protein YecS
UniProt: P0AFT2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14037
Length: 222 (214)
Sequences: 14976
Seq/Len: 69.98

YECS
Paralog alert: 0.93 [within 20: 0.65] - ratio of genomes with paralogs
Cluster includes: ARTM ARTQ GLNP GLTJ GLTK HISM HISQ METI PHNE SSUC TAUC YECS YEHW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_F 96_S 3.237 1.00
128_T 131_Q 3.19 1.00
184_E 187_T 2.998 1.00
91_A 163_A 2.993 1.00
130_W 134_R 2.973 1.00
20_G 24_Q 2.905 1.00
175_A 192_A 2.621 1.00
123_A 132_T 2.529 1.00
150_S 207_Q 2.453 1.00
122_A 132_T 2.274 1.00
119_W 132_T 2.242 1.00
40_L 100_A 2.173 1.00
205_T 209_H 2.134 1.00
43_M 55_A 2.125 1.00
50_P 54_L 2.101 1.00
65_T 70_Q 2.082 1.00
41_A 107_L 2.057 1.00
209_H 212_N 1.988 1.00
118_Q 140_Q 1.959 1.00
26_S 157_V 1.904 1.00
122_A 136_A 1.898 1.00
40_L 104_A 1.894 1.00
45_L 111_I 1.887 1.00
36_L 100_A 1.825 1.00
131_Q 135_R 1.823 1.00
24_Q 28_G 1.803 1.00
119_W 123_A 1.763 1.00
50_P 53_W 1.74 1.00
49_W 53_W 1.664 1.00
19_A 199_M 1.658 1.00
28_G 92_M 1.649 1.00
59_I 104_A 1.645 1.00
33_G 99_T 1.582 1.00
173_R 177_L 1.57 1.00
16_L 20_G 1.567 1.00
24_Q 88_I 1.564 1.00
36_L 96_S 1.552 1.00
209_H 213_Q 1.55 1.00
110_A 145_A 1.542 1.00
129_P 132_T 1.489 1.00
197_W 201_T 1.486 1.00
205_T 208_N 1.481 1.00
213_Q 216_R 1.476 1.00
37_G 103_A 1.476 1.00
30_M 153_F 1.474 1.00
201_T 205_T 1.473 1.00
122_A 127_M 1.468 1.00
44_R 56_R 1.458 1.00
21_Y 24_Q 1.451 1.00
49_W 52_R 1.448 1.00
103_A 152_S 1.444 1.00
110_A 144_V 1.432 1.00
74_I 93_I 1.43 1.00
18_G 174_Q 1.41 1.00
41_A 45_L 1.409 1.00
32_F 92_M 1.409 1.00
86_D 89_P 1.401 0.99
35_L 39_I 1.397 0.99
22_T 160_T 1.387 0.99
52_R 112_S 1.372 0.99
89_P 93_I 1.365 0.99
128_T 132_T 1.352 0.99
88_I 92_M 1.348 0.99
107_L 145_A 1.342 0.99
129_P 133_M 1.338 0.99
127_M 131_Q 1.326 0.99
131_Q 134_R 1.32 0.99
113_S 144_V 1.308 0.99
206_L 209_H 1.29 0.99
26_S 160_T 1.283 0.99
25_L 88_I 1.271 0.99
161_S 196_Y 1.264 0.99
17_K 20_G 1.264 0.99
206_L 210_F 1.259 0.99
45_L 112_S 1.259 0.99
119_W 137_I 1.251 0.99
123_A 129_P 1.238 0.98
111_I 137_I 1.227 0.98
25_L 163_A 1.218 0.98
37_G 104_A 1.208 0.98
174_Q 177_L 1.204 0.98
36_L 39_I 1.203 0.98
157_V 203_L 1.188 0.98
65_T 98_N 1.158 0.97
179_T 185_V 1.148 0.97
38_F 107_L 1.146 0.97
48_I 51_V 1.145 0.97
34_L 149_L 1.144 0.97
41_A 111_I 1.142 0.97
116_K 120_E 1.139 0.97
43_M 51_V 1.129 0.97
29_G 156_L 1.127 0.97
52_R 56_R 1.104 0.96
39_I 43_M 1.098 0.96
29_G 95_L 1.093 0.96
14_F 17_K 1.09 0.96
176_Q 179_T 1.089 0.96
70_Q 98_N 1.085 0.96
100_A 104_A 1.068 0.95
175_A 188_M 1.065 0.95
121_A 125_I 1.064 0.95
46_S 129_P 1.045 0.94
12_L 16_L 1.034 0.94
17_K 21_Y 1.03 0.94
163_A 170_E 1.005 0.93
54_L 58_Y 1.004 0.93
87_P 168_V 1.002 0.92
30_M 156_L 1.001 0.92
44_R 104_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.936999.90.478Contact Map0.792
2onkC40.97399.90.489Contact Map0.642
3d31C20.968599.90.49Contact Map0.587
3rlfF10.95599.90.501Contact Map0.676
3rlfG10.98299.80.555Contact Map0.591
3w9iA60.86046.60.947Contact Map0.386
4dx5A30.86045.40.949Contact Map0.34
3j27A30.4733.30.954Contact Map0.185
4cbfA20.4733.30.954Contact Map0.072
4azxA30.4733.20.955Contact Map0.085

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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