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HPF - Ribosome hibernation promoting factor
UniProt: P0AFX0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11681
Length: 95 (95)
Sequences: 1266
Seq/Len: 13.33

HPF
Paralog alert: 0.26 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: HPF RAIA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_G 73_A 3.985 1.00
16_L 70_M 2.486 1.00
41_L 50_S 2.39 1.00
14_E 18_E 1.939 1.00
20_V 41_L 1.854 1.00
30_Y 82_A 1.793 1.00
43_V 48_H 1.786 1.00
7_G 12_I 1.715 1.00
53_T 62_H 1.66 1.00
52_A 77_L 1.658 1.00
18_E 22_A 1.643 1.00
44_E 49_T 1.615 1.00
83_R 87_K 1.615 1.00
24_F 78_I 1.593 1.00
19_F 74_I 1.56 1.00
41_L 70_M 1.529 1.00
12_I 17_R 1.434 1.00
37_V 54_L 1.431 1.00
50_S 73_A 1.368 0.99
49_T 66_E 1.367 0.99
63_A 84_Q 1.342 0.99
86_T 90_D 1.331 0.99
48_H 70_M 1.314 0.99
51_D 62_H 1.303 0.99
29_Q 82_A 1.278 0.99
70_M 74_I 1.274 0.99
56_V 85_L 1.253 0.99
47_T 66_E 1.243 0.98
65_A 76_G 1.24 0.98
31_F 85_L 1.212 0.98
51_D 80_K 1.176 0.98
56_V 88_H 1.168 0.97
7_G 13_T 1.162 0.97
27_L 85_L 1.16 0.97
19_F 72_A 1.15 0.97
55_H 60_E 1.144 0.97
24_F 52_A 1.139 0.97
22_A 25_A 1.121 0.97
13_T 16_L 1.099 0.96
8_N 42_K 1.099 0.96
6_T 40_V 1.074 0.95
67_G 72_A 1.065 0.95
49_T 64_S 1.062 0.95
39_V 52_A 1.062 0.95
6_T 38_Y 1.061 0.95
10_V 71_Y 1.058 0.95
65_A 80_K 1.058 0.95
87_K 90_D 1.057 0.95
26_K 79_D 1.038 0.94
63_A 77_L 1.033 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3v2cY111000.059Contact Map0.734
3v26X111000.071Contact Map0.521
3tqmA411000.072Contact Map0.733
1imuA111000.073Contact Map0.724
4fylA211000.074Contact Map0.789
2ywqA4199.90.102Contact Map0.916
1pu1A10.822.90.893Contact Map0.22
3r84A120.736816.70.9Contact Map0.267
3ux2A10.813.10.904Contact Map0.119
3ghgA40.978911.80.907Contact Map0.014

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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