GREMLIN.BAKERLAB.org
Powered by OPENSEQ.org
UGPC - sn-glycerol-3-phosphate import ATP-binding protein UgpC
UniProt: P10907 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11048
Length: 356 (355)
Sequences: 9116
Seq/Len: 25.68

UGPC
Paralog alert: 0.83 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: ARTP BTUD CCMA CYSA DDPD DDPF DPPD DPPF FBPC FECE FEPC FHUC FTSE GLNQ GLTL HISP LIVF LIVG LOLD LPTB MALK METN MLAF MODC NIKD NIKE OPPD OPPF PHNC PHNK PHNL POTA POTG PROV PSTB SAPD SAPF SSUB SUFC TAUB THIQ UGPC YADG YBBA YBBL YCJV YDCT YECC YEHX YHDZ YNJD ZNUC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
217_G 221_E 4.642 1.00
34_V 202_A 4.446 1.00
120_R 125_D 4.146 1.00
31_E 204_R 3.93 1.00
60_D 67_R 3.756 1.00
214_E 228_S 3.752 1.00
297_M 313_G 3.394 1.00
5_K 26_D 3.32 1.00
7_Q 60_D 3.196 1.00
112_A 116_K 3.177 1.00
107_G 110_Q 2.995 1.00
300_D 314_R 2.855 1.00
8_A 22_P 2.831 1.00
127_L 130_R 2.762 1.00
94_E 129_K 2.7 1.00
21_K 212_V 2.689 1.00
94_E 98_A 2.61 1.00
8_A 24_T 2.582 1.00
94_E 116_K 2.552 1.00
114_R 152_D 2.531 1.00
119_A 128_L 2.519 1.00
64_N 154_A 2.496 1.00
179_Q 183_R 2.468 1.00
206_M 213_A 2.46 1.00
94_E 115_V 2.455 1.00
296_P 335_T 2.42 1.00
63_I 68_V 2.405 1.00
33_I 206_M 2.405 1.00
298_V 335_T 2.399 1.00
118_A 150_V 2.371 1.00
218_T 221_E 2.358 1.00
49_M 61_I 2.357 1.00
66_Q 154_A 2.302 1.00
94_E 112_A 2.295 1.00
20_I 49_M 2.281 1.00
4_L 155_V 2.243 1.00
50_V 189_L 2.156 1.00
6_L 9_V 2.14 1.00
209_N 214_E 2.123 1.00
206_M 216_I 2.089 1.00
28_A 31_E 2.075 1.00
77_G 154_A 2.044 1.00
18_Q 21_K 2.017 1.00
98_A 115_V 2.012 1.00
331_T 334_S 1.995 1.00
5_K 62_W 1.98 1.00
298_V 314_R 1.942 1.00
229_L 277_T 1.928 1.00
48_R 54_E 1.923 1.00
62_W 67_R 1.921 1.00
158_F 188_S 1.917 1.00
296_P 337_W 1.899 1.00
95_E 102_K 1.895 1.00
10_T 22_P 1.886 1.00
113_E 117_E 1.871 1.00
7_Q 62_W 1.866 1.00
12_S 18_Q 1.831 1.00
123_E 172_Q 1.823 1.00
10_T 18_Q 1.8 1.00
6_L 50_V 1.797 1.00
122_L 146_G 1.796 1.00
110_Q 113_E 1.775 1.00
207_V 231_V 1.75 1.00
11_K 49_M 1.74 1.00
111_I 115_V 1.736 1.00
98_A 111_I 1.727 1.00
97_M 146_G 1.724 1.00
10_T 58_E 1.702 1.00
88_Y 100_G 1.678 1.00
223_Y 283_E 1.675 1.00
66_Q 71_M 1.664 1.00
246_R 275_K 1.661 1.00
11_K 54_E 1.644 1.00
229_L 242_L 1.634 1.00
109_Q 113_E 1.634 1.00
92_S 95_E 1.62 1.00
229_L 233_S 1.615 1.00
240_M 279_G 1.601 1.00
20_I 46_L 1.591 1.00
49_M 56_V 1.587 1.00
106_M 111_I 1.564 1.00
33_I 216_I 1.557 1.00
233_S 242_L 1.554 1.00
6_L 25_L 1.514 1.00
242_L 277_T 1.508 1.00
11_K 57_T 1.5 1.00
100_G 151_R 1.497 1.00
106_M 110_Q 1.496 1.00
68_V 71_M 1.483 1.00
117_E 152_D 1.469 1.00
33_I 204_R 1.466 1.00
41_C 208_M 1.465 1.00
72_E 75_D 1.453 1.00
116_K 128_L 1.45 1.00
244_T 275_K 1.442 1.00
62_W 65_D 1.439 1.00
110_Q 114_R 1.436 1.00
308_D 323_R 1.435 1.00
313_G 338_L 1.431 1.00
23_L 46_L 1.422 1.00
97_M 119_A 1.409 1.00
25_L 206_M 1.405 0.99
118_A 149_I 1.403 0.99
114_R 117_E 1.401 0.99
28_A 204_R 1.393 0.99
92_S 131_R 1.391 0.99
221_E 225_K 1.387 0.99
284_H 344_Q 1.374 0.99
6_L 46_L 1.367 0.99
117_E 120_R 1.357 0.99
5_K 65_D 1.339 0.99
12_S 58_E 1.334 0.99
245_G 276_M 1.333 0.99
60_D 69_T 1.333 0.99
178_Q 201_L 1.33 0.99
302_L 311_A 1.329 0.99
181_H 186_T 1.323 0.99
56_V 61_I 1.321 0.99
162_L 177_L 1.309 0.99
220_V 224_E 1.298 0.99
181_H 188_S 1.295 0.99
25_L 216_I 1.272 0.99
56_V 69_T 1.271 0.99
116_K 120_R 1.259 0.99
67_R 70_E 1.259 0.99
108_K 112_A 1.252 0.99
209_N 230_F 1.249 0.99
79_A 151_R 1.246 0.98
32_F 181_H 1.231 0.98
20_I 23_L 1.231 0.98
102_K 108_K 1.23 0.98
152_D 183_R 1.229 0.98
116_K 125_D 1.214 0.98
286_A 339_H 1.214 0.98
35_M 206_M 1.207 0.98
99_W 103_I 1.206 0.98
12_S 19_V 1.206 0.98
162_L 190_Y 1.173 0.98
8_A 58_E 1.168 0.97
32_F 201_L 1.163 0.97
244_T 277_T 1.158 0.97
204_R 216_I 1.141 0.97
10_T 21_K 1.133 0.97
299_M 311_A 1.131 0.97
9_V 49_M 1.128 0.97
9_V 56_V 1.121 0.97
225_K 346_H 1.116 0.96
29_D 64_N 1.097 0.96
224_E 304_I 1.097 0.96
123_E 176_E 1.096 0.96
79_A 188_S 1.094 0.96
71_M 75_D 1.091 0.96
285_I 340_L 1.087 0.96
85_Y 164_N 1.086 0.96
215_Q 231_V 1.086 0.96
314_R 317_E 1.082 0.96
280_I 285_I 1.079 0.95
217_G 222_V 1.077 0.95
117_E 183_R 1.076 0.95
349_D 352_T 1.073 0.95
195_Q 234_F 1.071 0.95
288_S 337_W 1.066 0.95
97_M 118_A 1.066 0.95
95_E 98_A 1.065 0.95
341_A 344_Q 1.062 0.95
313_G 322_V 1.057 0.95
168_K 233_S 1.051 0.94
7_Q 24_T 1.04 0.94
9_V 61_I 1.037 0.94
61_I 68_V 1.032 0.94
119_A 124_L 1.028 0.94
178_Q 182_R 1.027 0.94
297_M 336_L 1.024 0.93
297_M 315_W 1.021 0.93
97_M 115_V 1.014 0.93
158_F 190_Y 1.012 0.93
207_V 222_V 1.012 0.93
286_A 341_A 1.005 0.93
32_F 188_S 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1v43A10.98881000.147Contact Map0.844
2it1A20.99161000.147Contact Map0.865
1g29120.99161000.163Contact Map0.879
2yyzA10.98881000.164Contact Map0.781
3rlfA20.99721000.167Contact Map0.822
1oxxK10.95221000.169Contact Map0.73
3fvqA20.98031000.188Contact Map0.75
3d31A20.94381000.195Contact Map0.741
1z47A20.95791000.215Contact Map0.843
3gd7A40.96351000.276Contact Map0.713

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0348 seconds.