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ARGC - N-acetyl-gamma-glutamyl-phosphate reductase
UniProt: P11446 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10065
Length: 334 (330)
Sequences: 3417
Seq/Len: 10.35

ARGC
Paralog alert: 0.76 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ARGC DHAS USG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
3_N 28_N 4.257 1.00
164_K 168_D 3.93 1.00
256_V 300_L 3.44 1.00
155_Y 184_S 3.414 1.00
44_L 57_D 3.396 1.00
5_L 73_V 2.778 1.00
271_R 288_F 2.775 1.00
151_V 320_C 2.565 1.00
44_L 59_P 2.514 1.00
271_R 290_D 2.429 1.00
115_E 121_T 2.388 1.00
311_K 319_Q 2.319 1.00
268_P 330_T 2.285 1.00
258_Q 262_Q 2.237 1.00
46_S 57_D 2.219 1.00
140_G 267_K 2.204 1.00
86_H 105_A 2.199 1.00
176_Q 246_R 2.182 1.00
181_N 242_T 2.134 1.00
27_M 321_A 2.134 1.00
20_Y 318_V 2.132 1.00
149_I 324_R 2.071 1.00
77_F 321_A 2.034 1.00
87_D 91_Q 2.019 1.00
278_P 292_G 2.016 1.00
98_V 324_R 2.014 1.00
158_A 241_E 2.002 1.00
166_L 247_L 1.978 1.00
38_S 62_P 1.977 1.00
155_Y 182_A 1.962 1.00
252_T 255_Q 1.938 1.00
189_A 205_Q 1.936 1.00
162_A 302_I 1.888 1.00
75_V 321_A 1.886 1.00
17_L 77_F 1.873 1.00
169_A 259_V 1.869 1.00
255_Q 258_Q 1.86 1.00
158_A 306_E 1.857 1.00
16_E 19_T 1.798 1.00
16_E 237_R 1.798 1.00
24_H 322_N 1.772 1.00
9_A 32_L 1.702 1.00
272_L 293_F 1.689 1.00
159_A 241_E 1.662 1.00
253_Q 293_F 1.661 1.00
98_V 149_I 1.646 1.00
159_A 180_I 1.645 1.00
169_A 255_Q 1.644 1.00
257_A 261_Q 1.635 1.00
130_Q 147_N 1.611 1.00
258_Q 261_Q 1.607 1.00
173_D 248_K 1.601 1.00
3_N 30_T 1.589 1.00
162_A 243_I 1.586 1.00
179_V 244_T 1.567 1.00
63_M 88_L 1.558 1.00
180_I 243_I 1.551 1.00
4_T 75_V 1.544 1.00
163_L 245_C 1.532 1.00
138_W 164_K 1.523 1.00
109_N 119_G 1.516 1.00
13_A 314_A 1.511 1.00
7_V 63_M 1.51 1.00
191_R 195_I 1.508 1.00
182_A 241_E 1.495 1.00
269_L 287_P 1.493 1.00
235_F 280_L 1.481 1.00
163_L 177_W 1.479 1.00
3_N 74_D 1.477 1.00
159_A 243_I 1.475 1.00
189_A 193_A 1.459 1.00
257_A 274_D 1.453 1.00
140_G 329_E 1.437 1.00
238_G 308_N 1.435 1.00
110_D 119_G 1.42 1.00
83_E 105_A 1.416 1.00
91_Q 94_E 1.41 1.00
204_L 233_G 1.386 0.99
328_A 331_Q 1.375 0.99
90_P 94_E 1.374 0.99
168_D 263_A 1.369 0.99
177_W 245_C 1.366 0.99
64_S 67_S 1.356 0.99
160_Q 221_H 1.354 0.99
93_L 148_L 1.35 0.99
260_L 272_L 1.315 0.99
88_L 91_Q 1.299 0.99
135_L 160_Q 1.298 0.99
7_V 78_L 1.296 0.99
208_G 213_R 1.292 0.99
217_E 220_T 1.289 0.99
44_L 47_D 1.287 0.99
310_L 315_A 1.283 0.99
162_A 260_L 1.279 0.99
140_G 323_I 1.275 0.99
240_L 280_L 1.269 0.99
26_H 29_I 1.259 0.99
30_T 61_Q 1.258 0.99
289_C 304_A 1.255 0.99
166_L 260_L 1.25 0.99
21_V 27_M 1.248 0.99
327_Y 331_Q 1.247 0.99
22_N 53_K 1.243 0.98
141_N 144_K 1.232 0.98
253_Q 295_V 1.231 0.98
254_A 258_Q 1.225 0.98
89_A 148_L 1.223 0.98
158_A 182_A 1.221 0.98
250_G 295_V 1.217 0.98
186_V 209_V 1.211 0.98
287_P 310_L 1.211 0.98
170_D 251_V 1.207 0.98
142_K 223_G 1.198 0.98
175_N 248_K 1.197 0.98
227_I 244_T 1.196 0.98
162_A 304_A 1.193 0.98
112_T 115_E 1.192 0.98
253_Q 257_A 1.189 0.98
175_N 246_R 1.183 0.98
159_A 218_I 1.18 0.98
310_L 318_V 1.175 0.98
40_D 43_K 1.165 0.97
75_V 325_F 1.153 0.97
78_L 89_A 1.152 0.97
18_V 29_I 1.151 0.97
76_V 97_C 1.146 0.97
10_S 60_L 1.145 0.97
25_P 331_Q 1.14 0.97
213_R 216_P 1.14 0.97
237_R 309_L 1.134 0.97
212_H 216_P 1.134 0.97
245_C 300_L 1.125 0.97
183_T 233_G 1.125 0.97
173_D 246_R 1.123 0.97
43_K 47_D 1.121 0.97
77_F 317_A 1.121 0.97
90_P 99_V 1.119 0.96
143_L 323_I 1.114 0.96
2_L 325_F 1.114 0.96
166_L 300_L 1.111 0.96
86_H 123_Q 1.108 0.96
260_L 302_I 1.105 0.96
21_V 318_V 1.103 0.96
245_C 302_I 1.101 0.96
65_D 68_E 1.099 0.96
139_C 142_K 1.098 0.96
30_T 73_V 1.097 0.96
214_H 217_E 1.096 0.96
89_A 99_V 1.09 0.96
5_L 76_V 1.083 0.96
4_T 27_M 1.083 0.96
136_A 323_I 1.074 0.95
286_L 290_D 1.069 0.95
154_C 188_G 1.066 0.95
85_S 106_F 1.061 0.95
142_K 145_E 1.056 0.95
289_C 306_E 1.054 0.95
65_D 87_D 1.053 0.95
240_L 305_T 1.05 0.94
158_A 304_A 1.049 0.94
19_T 23_R 1.046 0.94
169_A 249_S 1.042 0.94
166_L 256_V 1.042 0.94
214_H 218_I 1.041 0.94
158_A 305_T 1.033 0.94
141_N 223_G 1.03 0.94
137_E 319_Q 1.028 0.94
233_G 280_L 1.022 0.93
91_Q 95_A 1.014 0.93
137_E 311_K 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vknA40.96411000.136Contact Map0.806
1xygA40.9761000.189Contact Map0.769
2nqtA20.95511000.207Contact Map0.706
3dr3A10.9851000.231Contact Map0.733
2ozpA10.97311000.242Contact Map0.686
3hskA20.93711000.328Contact Map0.734
4dplA40.90421000.329Contact Map0.767
2yv3A20.86531000.332Contact Map0.649
3uw3A20.87131000.336Contact Map0.693
2ep5A40.90421000.336Contact Map0.765

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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