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ARLY - Argininosuccinate lyase
UniProt: P11447 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11223
Length: 457 (455)
Sequences: 5272
Seq/Len: 11.59

ARLY
Paralog alert: 0.85 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ARLY ASPA FUMC PUR8
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
38_V 63_N 3.344 1.00
45_V 55_Q 3.309 1.00
302_A 331_A 3.278 1.00
355_R 358_E 3.274 1.00
126_S 187_L 3.118 1.00
394_E 398_Q 3.104 1.00
42_K 59_E 3.035 1.00
246_M 299_V 2.848 1.00
165_F 351_V 2.783 1.00
417_I 420_D 2.745 1.00
133_R 180_E 2.704 1.00
148_D 353_R 2.668 1.00
129_L 180_E 2.658 1.00
136_Q 177_A 2.648 1.00
189_R 237_E 2.634 1.00
144_Q 453_Q 2.61 1.00
138_A 347_D 2.598 1.00
133_R 184_Q 2.572 1.00
295_K 338_C 2.543 1.00
357_Q 361_Q 2.533 1.00
268_E 350_Q 2.473 1.00
42_K 215_W 2.465 1.00
28_R 333_D 2.461 1.00
91_K 95_K 2.427 1.00
32_Q 123_D 2.407 1.00
125_V 238_L 2.381 1.00
141_E 145_N 2.348 1.00
243_A 303_L 2.339 1.00
142_T 145_N 2.31 1.00
129_L 184_Q 2.302 1.00
444_Q 447_Q 2.279 1.00
138_A 343_A 2.258 1.00
141_E 347_D 2.223 1.00
138_A 346_L 2.22 1.00
122_K 191_D 2.205 1.00
45_V 52_A 2.134 1.00
46_T 211_Q 2.121 1.00
180_E 184_Q 2.111 1.00
136_Q 180_E 2.067 1.00
131_A 340_H 2.064 1.00
268_E 352_K 2.056 1.00
191_D 219_A 2.038 1.00
247_V 300_Q 2.011 1.00
51_T 54_E 2.002 1.00
185_D 188_K 1.948 1.00
355_R 359_A 1.947 1.00
147_Q 446_A 1.931 1.00
134_Q 343_A 1.912 1.00
400_K 408_S 1.896 1.00
140_V 177_A 1.86 1.00
56_A 60_E 1.844 1.00
52_A 56_A 1.837 1.00
249_L 292_I 1.834 1.00
343_A 347_D 1.825 1.00
353_R 357_Q 1.82 1.00
379_V 387_I 1.808 1.00
185_D 189_R 1.801 1.00
394_E 409_E 1.788 1.00
253_A 292_I 1.779 1.00
131_A 336_L 1.766 1.00
222_T 228_S 1.764 1.00
420_D 423_P 1.748 1.00
3_L 94_D 1.738 1.00
387_I 415_Q 1.715 1.00
357_Q 428_Q 1.715 1.00
193_S 213_A 1.712 1.00
146_N 149_A 1.681 1.00
188_K 219_A 1.653 1.00
38_V 59_E 1.642 1.00
387_I 390_E 1.634 1.00
403_E 422_Y 1.633 1.00
298_R 327_G 1.624 1.00
54_E 102_K 1.617 1.00
64_V 95_K 1.611 1.00
178_R 227_D 1.61 1.00
243_A 307_M 1.61 1.00
179_D 248_H 1.601 1.00
270_S 348_G 1.591 1.00
238_L 332_L 1.584 1.00
55_Q 59_E 1.579 1.00
210_E 214_G 1.579 1.00
140_V 144_Q 1.577 1.00
197_C 228_S 1.569 1.00
178_R 233_D 1.56 1.00
211_Q 215_W 1.543 1.00
354_P 358_E 1.534 1.00
132_N 245_G 1.532 1.00
289_L 345_V 1.526 1.00
358_E 362_Q 1.525 1.00
35_V 123_D 1.513 1.00
182_R 237_E 1.506 1.00
136_Q 176_L 1.506 1.00
13_D 16_F 1.496 1.00
124_T 336_L 1.488 1.00
306_M 328_L 1.485 1.00
253_A 342_A 1.475 1.00
91_K 94_D 1.466 1.00
142_T 146_N 1.462 1.00
426_S 429_S 1.457 1.00
400_K 405_L 1.454 1.00
352_K 355_R 1.442 1.00
63_N 67_E 1.441 1.00
71_A 74_Q 1.428 1.00
128_L 335_W 1.424 1.00
236_L 310_L 1.422 1.00
93_I 100_G 1.421 1.00
133_R 137_S 1.417 1.00
181_S 188_K 1.4 0.99
211_Q 214_G 1.399 0.99
213_A 219_A 1.387 0.99
394_E 405_L 1.377 0.99
292_I 342_A 1.372 0.99
301_G 305_G 1.368 0.99
319_K 322_Q 1.367 0.99
144_Q 147_Q 1.359 0.99
38_V 42_K 1.358 0.99
292_I 338_C 1.356 0.99
136_Q 173_V 1.354 0.99
41_S 50_L 1.353 0.99
373_Y 420_D 1.346 0.99
240_S 244_I 1.341 0.99
252_F 342_A 1.337 0.99
183_L 245_G 1.335 0.99
169_C 172_Y 1.313 0.99
300_Q 308_M 1.312 0.99
377_K 420_D 1.306 0.99
298_R 330_D 1.302 0.99
418_D 422_Y 1.298 0.99
57_Q 60_E 1.297 0.99
186_A 241_A 1.286 0.99
236_L 244_I 1.281 0.99
31_E 70_R 1.277 0.99
173_V 452_A 1.277 0.99
134_Q 340_H 1.273 0.99
134_Q 347_D 1.272 0.99
143_A 173_V 1.271 0.99
33_D 112_Q 1.27 0.99
192_V 220_S 1.27 0.99
63_N 66_L 1.256 0.99
49_V 105_T 1.254 0.99
34_I 66_L 1.25 0.99
145_N 350_Q 1.249 0.99
57_Q 96_V 1.247 0.99
235_V 328_L 1.247 0.99
398_Q 405_L 1.246 0.98
181_S 189_R 1.243 0.98
132_N 180_E 1.242 0.98
138_A 141_E 1.241 0.98
165_F 169_C 1.237 0.98
60_E 95_K 1.233 0.98
303_L 307_M 1.233 0.98
241_A 245_G 1.23 0.98
121_C 328_L 1.225 0.98
96_V 103_L 1.225 0.98
142_T 346_L 1.21 0.98
172_Y 252_F 1.207 0.98
28_R 124_T 1.204 0.98
393_V 397_R 1.204 0.98
132_N 176_L 1.194 0.98
45_V 56_A 1.194 0.98
135_L 346_L 1.194 0.98
39_A 215_W 1.183 0.98
129_L 187_L 1.175 0.98
245_G 339_L 1.171 0.98
38_V 66_L 1.171 0.98
68_D 95_K 1.171 0.98
435_A 443_Q 1.165 0.97
170_L 224_N 1.165 0.97
131_A 343_A 1.164 0.97
92_L 103_L 1.163 0.97
129_L 133_R 1.161 0.97
33_D 36_G 1.16 0.97
135_L 343_A 1.159 0.97
267_V 349_I 1.159 0.97
407_L 418_D 1.154 0.97
149_A 356_C 1.147 0.97
238_L 328_L 1.14 0.97
56_A 59_E 1.134 0.97
121_C 238_L 1.131 0.97
98_Q 101_K 1.13 0.97
304_T 308_M 1.127 0.97
256_L 289_L 1.126 0.97
148_D 166_A 1.121 0.97
106_G 208_D 1.117 0.96
147_Q 166_A 1.114 0.96
46_T 52_A 1.114 0.96
139_L 252_F 1.113 0.96
141_E 453_Q 1.109 0.96
34_I 65_L 1.102 0.96
165_F 356_C 1.095 0.96
131_A 134_Q 1.094 0.96
31_E 123_D 1.093 0.96
181_S 185_D 1.089 0.96
250_S 293_R 1.077 0.95
239_L 328_L 1.074 0.95
156_H 290_E 1.065 0.95
45_V 50_L 1.051 0.94
210_E 437_K 1.05 0.94
57_Q 99_L 1.049 0.94
122_K 218_F 1.047 0.94
258_F 318_N 1.04 0.94
64_V 91_K 1.039 0.94
53_E 56_A 1.037 0.94
149_A 353_R 1.034 0.94
239_L 306_M 1.033 0.94
232_R 325_K 1.032 0.94
174_E 178_R 1.031 0.94
31_E 66_L 1.029 0.94
125_V 187_L 1.028 0.94
419_E 423_P 1.026 0.94
135_L 176_L 1.023 0.93
159_R 263_E 1.022 0.93
150_V 431_L 1.021 0.93
154_Y 159_R 1.018 0.93
77_L 84_I 1.012 0.93
140_V 173_V 1.012 0.93
142_T 169_C 1.012 0.93
106_G 207_I 1.011 0.93
132_N 339_L 1.004 0.93
191_D 218_F 1.004 0.93
245_G 335_W 1.003 0.93
185_D 237_E 1.002 0.92
35_V 215_W 1 0.92
400_K 409_E 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2e9fA40.99781000.021Contact Map0.751
1tj7A20.99781000.028Contact Map0.696
1k7wA40.99561000.029Contact Map0.732
1re5A40.94971000.165Contact Map0.644
1q5nA10.94971000.166Contact Map0.644
1c3cA20.92341000.197Contact Map0.691
2pfmA20.93651000.2Contact Map0.696
3c8tA10.94971000.202Contact Map0.62
3r6qA80.91681000.212Contact Map0.782
4admA40.92341000.213Contact Map0.705

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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