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BGLB - 6-phospho-beta-glucosidase BglB
UniProt: P11988 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10114
Length: 470 (458)
Sequences: 3243
Seq/Len: 7.08

BGLB
Paralog alert: 0.68 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: ASCB BGLA BGLB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
26_D 101_A 4.987 1.00
111_D 163_K 4.119 1.00
377_Q 446_K 4.089 1.00
392_V 402_I 3.443 1.00
107_D 163_K 3.343 1.00
66_P 112_E 3.277 1.00
60_D 63_H 3.229 1.00
73_A 116_A 3.209 1.00
124_L 156_V 3.203 1.00
100_E 104_A 3.178 1.00
100_E 159_R 3.075 1.00
112_E 115_Q 3.053 1.00
104_A 108_R 3.045 1.00
25_E 63_H 2.982 1.00
391_Q 394_E 2.974 1.00
299_Y 388_H 2.967 1.00
107_D 159_R 2.958 1.00
235_T 240_D 2.767 1.00
154_R 158_T 2.739 1.00
70_A 116_A 2.625 1.00
385_L 407_S 2.586 1.00
69_I 109_L 2.582 1.00
444_R 448_F 2.559 1.00
12_G 77_F 2.559 1.00
90_F 155_T 2.509 1.00
66_P 108_R 2.455 1.00
61_F 80_L 2.399 1.00
213_C 222_I 2.397 1.00
143_R 284_D 2.395 1.00
429_Y 443_T 2.366 1.00
347_N 398_D 2.344 1.00
343_R 398_D 2.338 1.00
101_A 104_A 2.283 1.00
379_D 446_K 2.283 1.00
383_A 387_D 2.279 1.00
79_C 406_T 2.257 1.00
211_K 215_S 2.159 1.00
283_S 286_E 2.147 1.00
147_D 208_R 2.122 1.00
433_D 437_E 2.113 1.00
61_F 105_F 2.083 1.00
200_H 263_Y 2.041 1.00
82_I 110_F 2.015 1.00
154_R 212_A 2.013 1.00
150_E 212_A 2.006 1.00
131_Y 135_K 1.999 1.00
114_A 163_K 1.998 1.00
14_T 19_V 1.995 1.00
119_K 165_A 1.983 1.00
31_S 87_A 1.98 1.00
107_D 111_D 1.965 1.00
431_D 439_S 1.949 1.00
111_D 114_A 1.947 1.00
452_A 456_K 1.928 1.00
82_I 109_L 1.894 1.00
110_F 114_A 1.874 1.00
299_Y 341_G 1.872 1.00
23_W 30_I 1.869 1.00
208_R 287_D 1.843 1.00
110_F 160_Y 1.836 1.00
453_E 461_S 1.815 1.00
35_L 131_Y 1.811 1.00
262_Q 289_K 1.806 1.00
168_L 294_F 1.79 1.00
371_E 375_S 1.787 1.00
343_R 347_N 1.782 1.00
69_I 116_A 1.777 1.00
10_W 458_R 1.773 1.00
112_E 116_A 1.763 1.00
70_A 112_E 1.751 1.00
113_M 118_I 1.748 1.00
265_G 269_R 1.747 1.00
22_A 25_E 1.741 1.00
340_V 391_Q 1.729 1.00
346_L 400_V 1.724 1.00
138_G 142_N 1.703 1.00
217_L 220_A 1.685 1.00
232_Y 344_V 1.677 1.00
84_I 122_V 1.677 1.00
358_F 403_M 1.675 1.00
119_K 166_L 1.647 1.00
370_V 443_T 1.634 1.00
30_I 35_L 1.622 1.00
29_G 93_G 1.605 1.00
343_R 394_E 1.586 1.00
22_A 26_D 1.583 1.00
121_L 406_T 1.583 1.00
69_I 112_E 1.574 1.00
79_C 121_L 1.573 1.00
453_E 456_K 1.55 1.00
145_V 148_H 1.544 1.00
103_L 155_T 1.532 0.99
213_C 220_A 1.526 0.99
150_E 208_R 1.526 0.99
157_F 213_C 1.525 0.99
253_F 267_M 1.515 0.99
60_D 64_R 1.507 0.99
65_Y 108_R 1.504 0.99
107_D 160_Y 1.5 0.99
165_A 219_E 1.496 0.99
450_W 454_V 1.493 0.99
64_R 67_E 1.486 0.99
162_H 217_L 1.48 0.99
72_F 428_I 1.475 0.99
69_I 113_M 1.471 0.99
137_Y 148_H 1.447 0.99
14_T 82_I 1.428 0.99
262_Q 268_Q 1.425 0.99
144_A 147_D 1.421 0.99
72_F 77_F 1.42 0.99
407_S 427_F 1.413 0.99
444_R 449_G 1.405 0.99
387_D 390_V 1.405 0.99
82_I 122_V 1.4 0.99
157_F 209_A 1.4 0.99
346_L 392_V 1.397 0.99
9_L 79_C 1.396 0.99
280_M 285_A 1.391 0.99
348_T 352_R 1.386 0.99
74_E 448_F 1.386 0.99
260_R 354_Q 1.377 0.99
212_A 215_S 1.377 0.99
14_T 80_L 1.373 0.99
35_L 135_K 1.362 0.98
132_G 136_N 1.362 0.98
389_L 392_V 1.36 0.98
451_Y 455_I 1.357 0.98
143_R 201_H 1.352 0.98
17_N 55_K 1.351 0.98
199_I 254_F 1.341 0.98
362_N 405_Y 1.335 0.98
22_A 63_H 1.328 0.98
154_R 216_L 1.326 0.98
107_D 162_H 1.317 0.98
5_P 396_I 1.307 0.98
92_Q 95_E 1.302 0.98
422_S 434_D 1.301 0.98
168_L 225_M 1.293 0.98
449_G 452_A 1.288 0.98
453_E 457_T 1.287 0.98
281_T 284_D 1.286 0.98
150_E 154_R 1.283 0.97
147_D 150_E 1.282 0.97
124_L 149_F 1.279 0.97
94_D 136_N 1.271 0.97
233_P 241_M 1.261 0.97
141_A 194_E 1.26 0.97
110_F 163_K 1.257 0.97
347_N 400_V 1.249 0.97
170_F 202_Q 1.248 0.97
29_G 132_G 1.247 0.97
107_D 114_A 1.235 0.97
156_V 160_Y 1.233 0.97
208_R 212_A 1.233 0.97
285_A 288_L 1.231 0.97
90_F 98_P 1.221 0.96
23_W 28_K 1.22 0.96
224_N 258_Q 1.218 0.96
262_Q 354_Q 1.216 0.96
241_M 244_A 1.214 0.96
4_F 396_I 1.213 0.96
262_Q 265_G 1.211 0.96
342_L 402_I 1.209 0.96
153_A 212_A 1.192 0.96
70_A 74_E 1.183 0.95
210_V 214_H 1.182 0.95
228_G 345_L 1.18 0.95
140_W 145_V 1.178 0.95
103_L 159_R 1.176 0.95
84_I 89_I 1.175 0.95
4_F 393_N 1.173 0.95
191_G 194_E 1.166 0.95
59_I 411_I 1.165 0.95
342_L 392_V 1.159 0.95
84_I 156_V 1.158 0.95
255_G 295_I 1.144 0.94
29_G 91_P 1.136 0.94
282_E 285_A 1.133 0.94
176_S 202_Q 1.125 0.94
213_C 218_P 1.119 0.93
61_F 109_L 1.118 0.93
393_N 460_L 1.117 0.93
103_L 107_D 1.117 0.93
144_A 148_H 1.116 0.93
121_L 358_F 1.116 0.93
110_F 122_V 1.111 0.93
38_H 56_D 1.108 0.93
333_W 365_G 1.103 0.93
393_N 397_A 1.095 0.92
170_F 205_A 1.083 0.92
370_V 375_S 1.082 0.92
342_L 359_I 1.08 0.92
142_N 148_H 1.073 0.91
150_E 209_A 1.072 0.91
431_D 441_T 1.072 0.91
259_A 355_K 1.067 0.91
166_L 221_K 1.067 0.91
249_R 266_Y 1.065 0.91
370_V 376_I 1.064 0.91
27_G 99_N 1.063 0.91
28_K 87_A 1.058 0.90
432_R 440_L 1.055 0.90
332_E 367_K 1.054 0.90
155_T 159_R 1.045 0.90
157_F 222_I 1.045 0.90
64_R 440_L 1.042 0.90
138_G 141_A 1.04 0.89
70_A 73_A 1.038 0.89
121_L 166_L 1.037 0.89
72_F 118_I 1.036 0.89
92_Q 97_E 1.029 0.89
162_H 220_A 1.023 0.88
189_E 194_E 1.017 0.88
57_V 432_R 1.015 0.88
103_L 156_V 1.015 0.88
129_M 139_G 1.015 0.88
120_P 165_A 1.012 0.88
136_N 144_A 1.011 0.88
228_G 297_F 1.01 0.88
374_G 443_T 1.008 0.87
233_P 244_A 1.007 0.87
89_I 155_T 1.007 0.87
340_V 344_V 1.007 0.87
213_C 217_L 1.003 0.87
114_A 120_P 1.003 0.87
256_D 260_R 1.002 0.87
350_W 401_D 1.001 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4ddeA20.97871000.087Contact Map0.812
4iplA20.9831000.091Contact Map0.85
3qomA10.97451000.094Contact Map0.803
1v02A50.97231000.099Contact Map0.776
2dgaA10.97231000.104Contact Map0.764
3ptmA20.94681000.107Contact Map0.762
2xhyA40.97661000.108Contact Map0.801
2jf7A20.97231000.108Contact Map0.713
1v08A20.96811000.109Contact Map0.787
4atdA20.94681000.114Contact Map0.744

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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