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AROC - Chorismate synthase
UniProt: P12008 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10075
Length: 361 (352)
Sequences: 1564
Seq/Len: 4.44

AROC
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
66_K 86_E 5.33 1.00
306_N 310_E 4.002 1.00
226_L 281_S 3.675 1.00
201_D 257_S 3.622 1.00
40_D 143_K 3.395 1.00
211_A 336_L 3.165 1.00
242_G 249_F 3.144 1.00
247_D 272_H 3.038 1.00
44_D 142_K 3.034 1.00
230_I 336_L 2.944 1.00
85_I 132_A 2.933 1.00
234_L 288_A 2.897 1.00
214_V 286_I 2.786 1.00
102_F 112_E 2.71 1.00
229_D 343_H 2.666 1.00
27_V 140_I 2.662 1.00
144_Y 341_M 2.568 1.00
234_L 336_L 2.46 1.00
30_V 81_I 2.458 1.00
72_F 120_Y 2.399 1.00
199_E 255_R 2.374 1.00
212_S 285_Q 2.324 1.00
172_Q 175_Q 2.318 1.00
15_F 82_G 2.286 1.00
159_Q 253_A 2.26 1.00
211_A 340_L 2.24 1.00
62_P 88_T 2.156 1.00
242_G 291_A 2.125 1.00
249_F 291_A 2.122 1.00
180_C 189_L 2.086 1.00
130_E 134_R 2.084 1.00
37_T 40_D 2.055 1.00
262_E 303_R 2.045 1.00
35_P 75_V 2.038 1.00
159_Q 164_P 2.02 1.00
195_A 199_E 1.998 1.00
153_I 337_A 1.92 1.00
156_C 181_P 1.903 1.00
146_A 152_E 1.902 1.00
159_Q 162_D 1.892 1.00
304_T 314_M 1.889 1.00
288_A 336_L 1.878 1.00
185_K 188_A 1.849 1.00
206_K 289_H 1.841 1.00
107_A 278_G 1.828 1.00
224_D 232_H 1.811 1.00
208_T 289_H 1.799 1.00
250_D 253_A 1.766 1.00
12_V 25_C 1.749 1.00
149_F 344_L 1.734 0.99
176_N 186_I 1.733 0.99
162_D 192_L 1.733 0.99
25_C 83_L 1.72 0.99
244_E 289_H 1.69 0.99
36_L 76_T 1.679 0.99
41_L 139_A 1.675 0.99
36_L 140_I 1.665 0.99
301_P 313_E 1.656 0.99
54_R 194_R 1.655 0.99
187_D 190_D 1.638 0.99
22_A 68_L 1.627 0.99
65_V 83_L 1.623 0.99
237_I 332_A 1.622 0.99
290_M 332_A 1.62 0.99
254_L 259_N 1.609 0.99
194_R 197_K 1.602 0.99
269_Q 303_R 1.593 0.99
229_D 232_H 1.581 0.99
154_R 173_V 1.549 0.99
192_L 196_L 1.519 0.98
276_I 286_I 1.519 0.98
15_F 24_G 1.514 0.98
205_A 325_G 1.483 0.98
260_R 302_G 1.481 0.98
36_L 40_D 1.477 0.98
211_A 214_V 1.476 0.98
37_T 143_K 1.475 0.98
233_A 339_V 1.463 0.98
22_A 84_L 1.459 0.98
5_T 13_T 1.456 0.98
210_V 285_Q 1.453 0.97
187_D 191_E 1.447 0.97
42_Q 46_D 1.446 0.97
123_G 221_P 1.438 0.97
292_L 332_A 1.436 0.97
177_P 190_D 1.435 0.97
8_Q 11_R 1.434 0.97
158_T 208_T 1.428 0.97
200_G 299_T 1.428 0.97
229_D 346_R 1.427 0.97
49_R 62_P 1.418 0.97
196_L 203_I 1.416 0.97
201_D 255_R 1.415 0.97
49_R 60_R 1.414 0.97
101_V 312_V 1.411 0.97
209_V 332_A 1.409 0.97
164_P 253_A 1.399 0.97
178_F 193_M 1.396 0.97
83_L 136_A 1.38 0.96
100_D 308_F 1.353 0.96
6_I 338_I 1.35 0.96
182_D 185_K 1.342 0.95
301_P 315_I 1.342 0.95
264_T 269_Q 1.341 0.95
25_C 133_M 1.337 0.95
71_V 81_I 1.328 0.95
160_M 323_C 1.322 0.95
251_V 259_N 1.313 0.95
105_G 277_L 1.31 0.95
102_F 307_R 1.308 0.95
155_G 329_V 1.304 0.94
21_L 66_K 1.297 0.94
23_L 133_M 1.293 0.94
112_E 307_R 1.292 0.94
34_I 144_Y 1.288 0.94
154_R 170_W 1.285 0.94
303_R 311_E 1.282 0.94
218_L 344_L 1.278 0.94
306_N 312_V 1.262 0.93
263_I 268_F 1.248 0.93
10_F 30_V 1.248 0.93
237_I 335_M 1.244 0.92
25_C 137_A 1.22 0.91
44_D 139_A 1.219 0.91
170_W 173_V 1.208 0.91
235_M 245_I 1.203 0.91
159_Q 252_V 1.188 0.90
208_T 287_I 1.187 0.90
152_E 212_S 1.183 0.90
276_I 281_S 1.181 0.90
343_H 346_R 1.18 0.90
228_A 232_H 1.172 0.89
75_V 117_L 1.17 0.89
81_I 140_I 1.17 0.89
109_Y 263_I 1.162 0.89
163_I 185_K 1.161 0.89
240_V 290_M 1.157 0.88
207_V 332_A 1.156 0.88
10_F 27_V 1.155 0.88
40_D 43_H 1.145 0.88
30_V 140_I 1.143 0.87
247_D 251_V 1.143 0.87
230_I 288_A 1.138 0.87
97_A 317_K 1.121 0.86
257_S 298_I 1.114 0.86
234_L 290_M 1.113 0.86
128_A 324_V 1.104 0.85
239_A 324_V 1.098 0.84
292_L 328_A 1.098 0.84
4_N 13_T 1.091 0.84
113_Q 216_A 1.089 0.84
243_V 288_A 1.089 0.84
130_E 222_V 1.079 0.83
33_G 75_V 1.074 0.83
151_I 344_L 1.069 0.82
252_V 291_A 1.066 0.82
281_S 286_I 1.066 0.82
240_V 292_L 1.063 0.82
159_Q 206_K 1.06 0.82
209_V 288_A 1.055 0.81
47_R 333_E 1.053 0.81
23_L 132_A 1.046 0.80
188_A 191_E 1.045 0.80
214_V 218_L 1.044 0.80
142_K 337_A 1.043 0.80
66_K 84_L 1.04 0.80
58_Q 89_D 1.036 0.79
150_G 213_G 1.036 0.79
199_E 300_V 1.031 0.79
101_V 304_T 1.031 0.79
163_I 188_A 1.03 0.79
192_L 195_A 1.016 0.78
156_C 208_T 1.008 0.77
202_S 295_T 1.008 0.77
142_K 333_E 1 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4lj2A211000.006Contact Map0.773
1sq1A10.98891000.019Contact Map0.747
1r53A10.99171000.021Contact Map0.74
1um0A40.98341000.021Contact Map0.861
4ecdA20.98611000.046Contact Map0.746
2o11A10.97781000.049Contact Map0.643
1q1lA40.98611000.057Contact Map0.866
1qxoA40.97231000.061Contact Map0.802
1vggA60.149627.50.979Contact Map0.41
2ekmA30.149622.10.98Contact Map0.319

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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